MotifGRHL1.H12INVITRO.0.PSM.A
Gene (human)GRHL1
(GeneCards)
Gene synonyms (human)LBP32, MGR, TFCP2L2
Gene (mouse)Grhl1
Gene synonyms (mouse)Mgr, Tcfcp2l2
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length19
ConsensusndAACCKGTWhdWChdGhh
GC content46.45%
Information content (bits; total / per base)16.271 / 0.856
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words9105

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 3 (20) 0.966 0.975 0.935 0.952 0.945 0.958 4.499 4.869 521.263 712.081

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 8 experiments median 0.999 0.999 0.996 0.994 0.948 0.95
best 1.0 1.0 1.0 0.999 0.997 0.996
Methyl HT-SELEX, 2 experiments median 1.0 0.999 0.999 0.998 0.996 0.994
best 1.0 1.0 0.999 0.999 0.996 0.995
Non-Methyl HT-SELEX, 6 experiments median 0.991 0.988 0.937 0.933 0.814 0.826
best 1.0 1.0 1.0 0.999 0.997 0.996

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.892 0.665 0.872 0.583
TF superclassImmunoglobulin fold {6} (TFClass)
TF classGrainyhead domain factors {6.7} (TFClass)
TF familyGrainyhead-related {6.7.1} (TFClass)
TF subfamilyGRH-like {6.7.1.1} (TFClass)
TFClass IDTFClass: 6.7.1.1.1
HGNCHGNC:17923
MGIMGI:2182540
EntrezGene (human)GeneID:29841
(SSTAR profile)
EntrezGene (mouse)GeneID:195733
(SSTAR profile)
UniProt ID (human)GRHL1_HUMAN
UniProt ID (mouse)GRHL1_MOUSE
UniProt AC (human)Q9NZI5
(TFClass)
UniProt AC (mouse)Q921D9
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 3 human, 0 mouse
HT-SELEX 6
Methyl-HT-SELEX 2
PCM
ACGT
013233.752219.751807.751843.75
024979.5759.51914.51451.5
038161.047.0494.0403.0
048767.010.037.0291.0
050.09100.04.01.0
061130.07320.033.0622.0
07951.076.06992.01086.0
086.03.09096.00.0
091293.0274.038.07500.0
101774.0999.0118.06214.0
113288.01028.0750.04039.0
124356.0565.01596.02588.0
135428.0310.01329.02038.0
14120.08600.0137.0248.0
152041.04185.01229.01650.0
163097.0677.03977.01354.0
17141.0718.08134.0112.0
182129.01516.01039.04421.0
192096.751925.751292.753789.75
PFM
ACGT
010.3550.2440.1990.202
020.5470.0830.210.159
030.8960.0050.0540.044
040.9630.0010.0040.032
050.00.9990.00.0
060.1240.8040.0040.068
070.1040.0080.7680.119
080.0010.00.9990.0
090.1420.030.0040.824
100.1950.110.0130.682
110.3610.1130.0820.444
120.4780.0620.1750.284
130.5960.0340.1460.224
140.0130.9450.0150.027
150.2240.460.1350.181
160.340.0740.4370.149
170.0150.0790.8930.012
180.2340.1670.1140.486
190.230.2120.1420.416
PWM
ACGT
010.351-0.025-0.23-0.21
020.782-1.096-0.173-0.449
031.276-3.834-1.524-1.727
041.348-5.223-4.061-2.05
05-6.9071.385-5.894-6.544
06-0.6991.167-4.168-1.295
07-0.871-3.3711.122-0.739
08-5.618-6.0681.385-6.907
09-0.565-2.11-4.0351.192
10-0.249-0.822-2.9411.004
110.367-0.794-1.1080.573
120.649-1.39-0.3550.128
130.868-1.987-0.537-0.11
14-2.9251.328-2.795-2.209
15-0.1090.609-0.615-0.321
160.308-1.210.558-0.519
17-2.766-1.1521.273-2.993
18-0.067-0.406-0.7830.663
19-0.082-0.167-0.5650.509
Standard thresholds
P-value Threshold
0.001 1.92876
0.0005 3.30806
0.0001 6.11476