GLI3.H12INVITRO.1.M.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	GLI3.H12INVITRO.1.M.C
Gene (human)	GLI3 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Gli3
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	C

Motif length	12
Consensus	nnGTGGTCCddn
GC content	56.63%
Information content (bits; total / per base)	13.422 / 1.119
Data sources	Methyl-HT-SELEX
Aligned words	2036

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	2 (8)	0.593	0.602	0.469	0.494	0.607	0.668	1.694	1.929	9.089	19.678

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.997	0.995	0.996	0.993	0.993	0.989
Overall, 2 experiments	best	0.999	0.998	0.998	0.997	0.997	0.995
Methyl HT-SELEX, 1 experiments	median	0.999	0.998	0.998	0.997	0.997	0.995
Methyl HT-SELEX, 1 experiments	best	0.999	0.998	0.998	0.997	0.997	0.995
Non-Methyl HT-SELEX, 1 experiments	median	0.996	0.992	0.994	0.989	0.989	0.983
Non-Methyl HT-SELEX, 1 experiments	best	0.996	0.992	0.994	0.989	0.989	0.983

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.557	0.115	0.166	0.017
batch 2	0.665	0.253	0.691	0.519

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	GLI-lile {2.3.3.1} (TFClass)
TFClass ID	TFClass: 2.3.3.1.3
HGNC	HGNC:4319
MGI	MGI:95729
EntrezGene (human)	GeneID:2737 (SSTAR profile)
EntrezGene (mouse)	GeneID:14634 (SSTAR profile)
UniProt ID (human)	GLI3_HUMAN
UniProt ID (mouse)	GLI3_MOUSE
UniProt AC (human)	P10071 (TFClass)
UniProt AC (mouse)	Q61602 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 2 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	GLI3.H12INVITRO.1.M.C.pcm
PWM	GLI3.H12INVITRO.1.M.C.pwm
PFM	GLI3.H12INVITRO.1.M.C.pfm
Alignment	GLI3.H12INVITRO.1.M.C.words.tsv
Threshold to P-value map	GLI3.H12INVITRO.1.M.C.thr
Motif in other formats
JASPAR format	GLI3.H12INVITRO.1.M.C_jaspar_format.txt
MEME format	GLI3.H12INVITRO.1.M.C_meme_format.meme
Transfac format	GLI3.H12INVITRO.1.M.C_transfac_format.txt
Homer format	GLI3.H12INVITRO.1.M.C_homer_format_0.001.txt GLI3.H12INVITRO.1.M.C_homer_format_0.0005.txt GLI3.H12INVITRO.1.M.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	439.0	433.0	731.0	433.0
02	419.75	431.75	741.75	442.75
03	0.0	0.0	2036.0	0.0
04	0.0	0.0	0.0	2036.0
05	0.0	0.0	2036.0	0.0
06	0.0	0.0	2036.0	0.0
07	0.0	0.0	0.0	2036.0
08	0.0	2036.0	0.0	0.0
09	0.0	1219.0	0.0	817.0
10	619.0	201.0	326.0	890.0
11	656.25	290.25	377.25	712.25
12	523.25	410.25	531.25	571.25

PFM

	A	C	G	T
01	0.216	0.213	0.359	0.213
02	0.206	0.212	0.364	0.217
03	0.0	0.0	1.0	0.0
04	0.0	0.0	0.0	1.0
05	0.0	0.0	1.0	0.0
06	0.0	0.0	1.0	0.0
07	0.0	0.0	0.0	1.0
08	0.0	1.0	0.0	0.0
09	0.0	0.599	0.0	0.401
10	0.304	0.099	0.16	0.437
11	0.322	0.143	0.185	0.35
12	0.257	0.201	0.261	0.281

PWM

	A	C	G	T
01	-0.147	-0.161	0.361	-0.161
02	-0.192	-0.164	0.375	-0.139
03	-5.592	-5.592	1.383	-5.592
04	-5.592	-5.592	-5.592	1.383
05	-5.592	-5.592	1.383	-5.592
06	-5.592	-5.592	1.383	-5.592
07	-5.592	-5.592	-5.592	1.383
08	-5.592	1.383	-5.592	-5.592
09	-5.592	0.871	-5.592	0.472
10	0.195	-0.923	-0.443	0.557
11	0.253	-0.559	-0.298	0.335
12	0.028	-0.215	0.043	0.115

Standard thresholds

P-value	Threshold
0.001	2.01906
0.0005	2.55096
0.0001	7.90719