GATA4.H12INVITRO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	GATA4.H12INVITRO.0.PSM.A
Gene (human)	GATA4 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Gata4
Gene synonyms (mouse)	Gata-4
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	9
Consensus	vWGATAASv
GC content	38.44%
Information content (bits; total / per base)	9.958 / 1.106
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	25 (162)	0.907	0.958	0.822	0.909	0.89	0.939	2.968	3.503	162.409	414.244
Mouse	40 (192)	0.888	0.949	0.786	0.898	0.85	0.929	2.658	3.422	160.102	348.854

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.985	0.971	0.977	0.964	0.935	0.922
Overall, 4 experiments	best	0.987	0.977	0.984	0.969	0.974	0.958
Methyl HT-SELEX, 1 experiments	median	0.985	0.973	0.982	0.969	0.972	0.956
Methyl HT-SELEX, 1 experiments	best	0.985	0.973	0.982	0.969	0.972	0.956
Non-Methyl HT-SELEX, 3 experiments	median	0.985	0.968	0.972	0.959	0.897	0.887
Non-Methyl HT-SELEX, 3 experiments	best	0.987	0.977	0.984	0.968	0.974	0.958

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Other C4 zinc finger-type factors {2.2} (TFClass)
TF family	C4-GATA-related {2.2.1} (TFClass)
TF subfamily	GATA double {2.2.1.1} (TFClass)
TFClass ID	TFClass: 2.2.1.1.4
HGNC	HGNC:4173
MGI	MGI:95664
EntrezGene (human)	GeneID:2626 (SSTAR profile)
EntrezGene (mouse)	GeneID:14463 (SSTAR profile)
UniProt ID (human)	GATA4_HUMAN
UniProt ID (mouse)	GATA4_MOUSE
UniProt AC (human)	P43694 (TFClass)
UniProt AC (mouse)	Q08369 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	25 human, 40 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	GATA4.H12INVITRO.0.PSM.A.pcm
PWM	GATA4.H12INVITRO.0.PSM.A.pwm
PFM	GATA4.H12INVITRO.0.PSM.A.pfm
Alignment	GATA4.H12INVITRO.0.PSM.A.words.tsv
Threshold to P-value map	GATA4.H12INVITRO.0.PSM.A.thr
Motif in other formats
JASPAR format	GATA4.H12INVITRO.0.PSM.A_jaspar_format.txt
MEME format	GATA4.H12INVITRO.0.PSM.A_meme_format.meme
Transfac format	GATA4.H12INVITRO.0.PSM.A_transfac_format.txt
Homer format	GATA4.H12INVITRO.0.PSM.A_homer_format_0.001.txt GATA4.H12INVITRO.0.PSM.A_homer_format_0.0005.txt GATA4.H12INVITRO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	152.0	433.0	313.0	102.0
02	638.0	39.0	16.0	307.0
03	4.0	3.0	993.0	0.0
04	992.0	3.0	2.0	3.0
05	10.0	4.0	12.0	974.0
06	909.0	3.0	9.0	79.0
07	797.0	14.0	171.0	18.0
08	111.0	265.0	587.0	37.0
09	349.0	250.0	343.0	58.0

PFM

	A	C	G	T
01	0.152	0.433	0.313	0.102
02	0.638	0.039	0.016	0.307
03	0.004	0.003	0.993	0.0
04	0.992	0.003	0.002	0.003
05	0.01	0.004	0.012	0.974
06	0.909	0.003	0.009	0.079
07	0.797	0.014	0.171	0.018
08	0.111	0.265	0.587	0.037
09	0.349	0.25	0.343	0.058

PWM

	A	C	G	T
01	-0.493	0.546	0.223	-0.887
02	0.933	-1.821	-2.653	0.204
03	-3.783	-3.975	1.374	-4.982
04	1.373	-3.975	-4.213	-3.975
05	-3.066	-3.783	-2.909	1.355
06	1.286	-3.975	-3.156	-1.137
07	1.155	-2.773	-0.377	-2.546
08	-0.803	0.058	0.85	-1.872
09	0.332	0.0	0.314	-1.439

Standard thresholds

P-value	Threshold
0.001	4.755895
0.0005	5.799565
0.0001	7.608425