GATA3.H12CORE.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	GATA3.H12CORE.0.PS.A
Gene (human)	GATA3 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Gata3
Gene synonyms (mouse)	Gata-3
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	9
Consensus	nhGATAAvn
GC content	35.59%
Information content (bits; total / per base)	9.409 / 1.045
Data sources	ChIP-Seq + HT-SELEX
Aligned words	9193

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	54 (340)	0.791	0.928	0.639	0.871	0.764	0.909	2.113	3.178	135.403	376.444
Mouse	29 (173)	0.802	0.859	0.662	0.745	0.763	0.828	2.198	2.58	201.086	467.046

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.921	0.885	0.776	0.764	0.631	0.657
Overall, 6 experiments	best	0.988	0.98	0.987	0.977	0.985	0.973
Methyl HT-SELEX, 1 experiments	median	0.988	0.98	0.987	0.977	0.985	0.973
Methyl HT-SELEX, 1 experiments	best	0.988	0.98	0.987	0.977	0.985	0.973
Non-Methyl HT-SELEX, 5 experiments	median	0.918	0.879	0.761	0.757	0.618	0.649
Non-Methyl HT-SELEX, 5 experiments	best	0.987	0.978	0.984	0.973	0.978	0.964

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	6.745	7.037	0.174	0.106

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.945	0.546	0.892	0.516
batch 2	0.688	0.351	0.701	0.522

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Other C4 zinc finger-type factors {2.2} (TFClass)
TF family	C4-GATA-related {2.2.1} (TFClass)
TF subfamily	GATA double {2.2.1.1} (TFClass)
TFClass ID	TFClass: 2.2.1.1.3
HGNC	HGNC:4172
MGI	MGI:95663
EntrezGene (human)	GeneID:2625 (SSTAR profile)
EntrezGene (mouse)	GeneID:14462 (SSTAR profile)
UniProt ID (human)	GATA3_HUMAN
UniProt ID (mouse)	GATA3_MOUSE
UniProt AC (human)	P23771 (TFClass)
UniProt AC (mouse)	P23772 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	54 human, 29 mouse
HT-SELEX	5
Methyl-HT-SELEX	1

PCM	GATA3.H12CORE.0.PS.A.pcm
PWM	GATA3.H12CORE.0.PS.A.pwm
PFM	GATA3.H12CORE.0.PS.A.pfm
Alignment	GATA3.H12CORE.0.PS.A.words.tsv
Threshold to P-value map	GATA3.H12CORE.0.PS.A.thr
Motif in other formats
JASPAR format	GATA3.H12CORE.0.PS.A_jaspar_format.txt
MEME format	GATA3.H12CORE.0.PS.A_meme_format.meme
Transfac format	GATA3.H12CORE.0.PS.A_transfac_format.txt
Homer format	GATA3.H12CORE.0.PS.A_homer_format_0.001.txt GATA3.H12CORE.0.PS.A_homer_format_0.0005.txt GATA3.H12CORE.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2459.0	2788.0	2197.0	1749.0
02	4801.25	1410.25	550.25	2431.25
03	1.0	24.0	9159.0	9.0
04	9192.0	0.0	1.0	0.0
05	0.0	0.0	0.0	9193.0
06	8920.0	159.0	2.0	112.0
07	7473.0	1002.0	399.0	319.0
08	1352.5	2673.5	4113.5	1053.5
09	2956.5	2132.5	2831.5	1272.5

PFM

	A	C	G	T
01	0.267	0.303	0.239	0.19
02	0.522	0.153	0.06	0.264
03	0.0	0.003	0.996	0.001
04	1.0	0.0	0.0	0.0
05	0.0	0.0	0.0	1.0
06	0.97	0.017	0.0	0.012
07	0.813	0.109	0.043	0.035
08	0.147	0.291	0.447	0.115
09	0.322	0.232	0.308	0.138

PWM

	A	C	G	T
01	0.068	0.193	-0.045	-0.273
02	0.736	-0.488	-1.426	0.056
03	-6.553	-4.472	1.382	-5.318
04	1.385	-6.916	-6.553	-6.916
05	-6.916	-6.916	-6.916	1.386
06	1.355	-2.658	-6.287	-3.002
07	1.178	-0.829	-1.746	-1.969
08	-0.529	0.151	0.582	-0.779
09	0.252	-0.075	0.208	-0.59

Standard thresholds

P-value	Threshold
0.001	5.186725
0.0005	6.238055
0.0001	7.52316