FOXO3.H12INVIVO.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	FOXO3.H12INVIVO.0.PS.A
Gene (human)	FOXO3 (GeneCards)
Gene synonyms (human)	FKHRL1, FOXO3A
Gene (mouse)	Foxo3
Gene synonyms (mouse)	Fkhr2, Foxo3a
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	10
Consensus	bbTGTTTACh
GC content	36.64%
Information content (bits; total / per base)	11.442 / 1.144
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1001

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (7)	0.874	0.886	0.797	0.823	0.894	0.91	3.566	3.718	275.201	297.678

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	0.71	0.68	0.616	0.607	0.56	0.565
Non-Methyl HT-SELEX, 2 experiments	best	0.717	0.687	0.619	0.611	0.562	0.567

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	FOX {3.3.1} (TFClass)
TF subfamily	FOXO {3.3.1.15} (TFClass)
TFClass ID	TFClass: 3.3.1.15.2
HGNC	HGNC:3821
MGI	MGI:1890081
EntrezGene (human)	GeneID:2309 (SSTAR profile)
EntrezGene (mouse)	GeneID:56484 (SSTAR profile)
UniProt ID (human)	FOXO3_HUMAN
UniProt ID (mouse)	FOXO3_MOUSE
UniProt AC (human)	O43524 (TFClass)
UniProt AC (mouse)	Q9WVH4 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	FOXO3.H12INVIVO.0.PS.A.pcm
PWM	FOXO3.H12INVIVO.0.PS.A.pwm
PFM	FOXO3.H12INVIVO.0.PS.A.pfm
Alignment	FOXO3.H12INVIVO.0.PS.A.words.tsv
Threshold to P-value map	FOXO3.H12INVIVO.0.PS.A.thr
Motif in other formats
JASPAR format	FOXO3.H12INVIVO.0.PS.A_jaspar_format.txt
MEME format	FOXO3.H12INVIVO.0.PS.A_meme_format.meme
Transfac format	FOXO3.H12INVIVO.0.PS.A_transfac_format.txt
Homer format	FOXO3.H12INVIVO.0.PS.A_homer_format_0.001.txt FOXO3.H12INVIVO.0.PS.A_homer_format_0.0005.txt FOXO3.H12INVIVO.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	111.0	414.0	306.0	170.0
02	60.0	384.0	170.0	387.0
03	10.0	1.0	1.0	989.0
04	49.0	6.0	943.0	3.0
05	2.0	7.0	14.0	978.0
06	5.0	7.0	35.0	954.0
07	0.0	10.0	148.0	843.0
08	839.0	50.0	14.0	98.0
09	5.0	848.0	8.0	140.0
10	387.0	245.0	57.0	312.0

PFM

	A	C	G	T
01	0.111	0.414	0.306	0.17
02	0.06	0.384	0.17	0.387
03	0.01	0.001	0.001	0.988
04	0.049	0.006	0.942	0.003
05	0.002	0.007	0.014	0.977
06	0.005	0.007	0.035	0.953
07	0.0	0.01	0.148	0.842
08	0.838	0.05	0.014	0.098
09	0.005	0.847	0.008	0.14
10	0.387	0.245	0.057	0.312

PWM

	A	C	G	T
01	-0.804	0.501	0.2	-0.383
02	-1.407	0.426	-0.383	0.434
03	-3.067	-4.526	-4.526	1.369
04	-1.603	-3.485	1.322	-3.976
05	-4.214	-3.363	-2.774	1.358
06	-3.623	-3.363	-1.926	1.333
07	-4.983	-3.067	-0.521	1.21
08	1.205	-1.583	-2.774	-0.927
09	-3.623	1.216	-3.254	-0.575
10	0.434	-0.021	-1.456	0.219

Standard thresholds

P-value	Threshold
0.001	4.24817
0.0005	5.29523
0.0001	7.437235