| Motif | FOXO3.H12CORE.0.PS.A |
| Gene (human) | FOXO3 (GeneCards) |
| Gene synonyms (human) | FKHRL1, FOXO3A |
| Gene (mouse) | Foxo3 |
| Gene synonyms (mouse) | Fkhr2, Foxo3a |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | A |
| Motif | FOXO3.H12CORE.0.PS.A |
| Gene (human) | FOXO3 (GeneCards) |
| Gene synonyms (human) | FKHRL1, FOXO3A |
| Gene (mouse) | Foxo3 |
| Gene synonyms (mouse) | Fkhr2, Foxo3a |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | A |
| Motif length | 9 |
| Consensus | bbTGTTTWC |
| GC content | 36.97% |
| Information content (bits; total / per base) | 11.178 / 1.242 |
| Data sources | ChIP-Seq + HT-SELEX |
| Aligned words | 995 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mouse | 1 (7) | 0.867 | 0.877 | 0.789 | 0.809 | 0.888 | 0.902 | 3.453 | 3.585 | 255.071 | 276.237 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Non-Methyl HT-SELEX, 2 experiments | median | 0.72 | 0.688 | 0.627 | 0.615 | 0.568 | 0.571 |
| best | 0.727 | 0.696 | 0.631 | 0.619 | 0.57 | 0.574 | |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Fork head/winged helix factors {3.3} (TFClass) |
| TF family | FOX {3.3.1} (TFClass) |
| TF subfamily | FOXO {3.3.1.15} (TFClass) |
| TFClass ID | TFClass: 3.3.1.15.2 |
| HGNC | HGNC:3821 |
| MGI | MGI:1890081 |
| EntrezGene (human) | GeneID:2309 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:56484 (SSTAR profile) |
| UniProt ID (human) | FOXO3_HUMAN |
| UniProt ID (mouse) | FOXO3_MOUSE |
| UniProt AC (human) | O43524 (TFClass) |
| UniProt AC (mouse) | Q9WVH4 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 0 human, 1 mouse |
| HT-SELEX | 2 |
| Methyl-HT-SELEX | 0 |
| PCM | FOXO3.H12CORE.0.PS.A.pcm |
| PWM | FOXO3.H12CORE.0.PS.A.pwm |
| PFM | FOXO3.H12CORE.0.PS.A.pfm |
| Alignment | FOXO3.H12CORE.0.PS.A.words.tsv |
| Threshold to P-value map | FOXO3.H12CORE.0.PS.A.thr |
| Motif in other formats | |
| JASPAR format | FOXO3.H12CORE.0.PS.A_jaspar_format.txt |
| MEME format | FOXO3.H12CORE.0.PS.A_meme_format.meme |
| Transfac format | FOXO3.H12CORE.0.PS.A_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 93.0 | 408.0 | 286.0 | 208.0 |
| 02 | 56.0 | 383.0 | 152.0 | 404.0 |
| 03 | 7.0 | 0.0 | 3.0 | 985.0 |
| 04 | 29.0 | 0.0 | 963.0 | 3.0 |
| 05 | 0.0 | 6.0 | 5.0 | 984.0 |
| 06 | 0.0 | 2.0 | 15.0 | 978.0 |
| 07 | 2.0 | 3.0 | 142.0 | 848.0 |
| 08 | 719.0 | 99.0 | 40.0 | 137.0 |
| 09 | 3.0 | 787.0 | 17.0 | 188.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.093 | 0.41 | 0.287 | 0.209 |
| 02 | 0.056 | 0.385 | 0.153 | 0.406 |
| 03 | 0.007 | 0.0 | 0.003 | 0.99 |
| 04 | 0.029 | 0.0 | 0.968 | 0.003 |
| 05 | 0.0 | 0.006 | 0.005 | 0.989 |
| 06 | 0.0 | 0.002 | 0.015 | 0.983 |
| 07 | 0.002 | 0.003 | 0.143 | 0.852 |
| 08 | 0.723 | 0.099 | 0.04 | 0.138 |
| 09 | 0.003 | 0.791 | 0.017 | 0.189 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.972 | 0.492 | 0.139 | -0.178 |
| 02 | -1.468 | 0.429 | -0.488 | 0.482 |
| 03 | -3.357 | -4.978 | -3.97 | 1.371 |
| 04 | -2.098 | -4.978 | 1.348 | -3.97 |
| 05 | -4.978 | -3.479 | -3.617 | 1.37 |
| 06 | -4.978 | -4.208 | -2.706 | 1.364 |
| 07 | -4.208 | -3.97 | -0.555 | 1.222 |
| 08 | 1.057 | -0.911 | -1.792 | -0.591 |
| 09 | -3.97 | 1.147 | -2.593 | -0.278 |
| P-value | Threshold |
|---|---|
| 0.001 | 4.26151 |
| 0.0005 | 5.45083 |
| 0.0001 | 7.69086 |