FOXO1.H12RSNP.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	FOXO1.H12RSNP.0.PS.A
Gene (human)	FOXO1 (GeneCards)
Gene synonyms (human)	FKHR, FOXO1A
Gene (mouse)	Foxo1
Gene synonyms (mouse)	Fkhr, Foxo1a
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	11
Consensus	nnhTGTTKhbn
GC content	37.15%
Information content (bits; total / per base)	7.682 / 0.698
Data sources	ChIP-Seq + HT-SELEX
Aligned words	971

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (20)	0.796	0.856	0.649	0.735	0.867	0.914	2.957	3.23	77.836	121.77
Mouse	12 (78)	0.642	0.805	0.48	0.644	0.699	0.881	2.149	3.067	41.484	248.027

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	0.652	0.619	0.591	0.575	0.554	0.549
Non-Methyl HT-SELEX, 2 experiments	best	0.679	0.644	0.605	0.59	0.561	0.557

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.64	0.313	0.585	0.374

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	FOX {3.3.1} (TFClass)
TF subfamily	FOXO {3.3.1.15} (TFClass)
TFClass ID	TFClass: 3.3.1.15.1
HGNC	HGNC:3819
MGI	MGI:1890077
EntrezGene (human)	GeneID:2308 (SSTAR profile)
EntrezGene (mouse)	GeneID:56458 (SSTAR profile)
UniProt ID (human)	FOXO1_HUMAN
UniProt ID (mouse)	FOXO1_MOUSE
UniProt AC (human)	Q12778 (TFClass)
UniProt AC (mouse)	Q9R1E0 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 12 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	FOXO1.H12RSNP.0.PS.A.pcm
PWM	FOXO1.H12RSNP.0.PS.A.pwm
PFM	FOXO1.H12RSNP.0.PS.A.pfm
Alignment	FOXO1.H12RSNP.0.PS.A.words.tsv
Threshold to P-value map	FOXO1.H12RSNP.0.PS.A.thr
Motif in other formats
JASPAR format	FOXO1.H12RSNP.0.PS.A_jaspar_format.txt
MEME format	FOXO1.H12RSNP.0.PS.A_meme_format.meme
Transfac format	FOXO1.H12RSNP.0.PS.A_transfac_format.txt
Homer format	FOXO1.H12RSNP.0.PS.A_homer_format_0.001.txt FOXO1.H12RSNP.0.PS.A_homer_format_0.0005.txt FOXO1.H12RSNP.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	249.0	172.0	263.0	287.0
02	189.0	302.0	265.0	215.0
03	239.0	354.0	97.0	281.0
04	17.0	2.0	2.0	950.0
05	34.0	31.0	888.0	18.0
06	19.0	99.0	9.0	844.0
07	12.0	5.0	79.0	875.0
08	38.0	71.0	165.0	697.0
09	408.0	101.0	78.0	384.0
10	57.0	461.0	140.0	313.0
11	326.0	257.0	127.0	261.0

PFM

	A	C	G	T
01	0.256	0.177	0.271	0.296
02	0.195	0.311	0.273	0.221
03	0.246	0.365	0.1	0.289
04	0.018	0.002	0.002	0.978
05	0.035	0.032	0.915	0.019
06	0.02	0.102	0.009	0.869
07	0.012	0.005	0.081	0.901
08	0.039	0.073	0.17	0.718
09	0.42	0.104	0.08	0.395
10	0.059	0.475	0.144	0.322
11	0.336	0.265	0.131	0.269

PWM

	A	C	G	T
01	0.025	-0.342	0.08	0.166
02	-0.248	0.217	0.087	-0.12
03	-0.015	0.375	-0.907	0.145
04	-2.57	-4.185	-4.185	1.359
05	-1.923	-2.011	1.292	-2.517
06	-2.468	-0.887	-3.127	1.241
07	-2.88	-3.594	-1.108	1.277
08	-1.817	-1.212	-0.383	1.05
09	0.516	-0.867	-1.121	0.456
10	-1.426	0.638	-0.545	0.253
11	0.293	0.057	-0.641	0.072

Standard thresholds

P-value	Threshold
0.001	5.19106
0.0005	5.85585
0.0001	7.217795