MotifFOXO1.H12CORE.0.PS.A
Gene (human)FOXO1
(GeneCards)
Gene synonyms (human)FKHR, FOXO1A
Gene (mouse)Foxo1
Gene synonyms (mouse)Fkhr, Foxo1a
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length9
ConsensusbTGTTTWCn
GC content36.54%
Information content (bits; total / per base)9.633 / 1.07
Data sourcesChIP-Seq + HT-SELEX
Aligned words999

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 3 (20) 0.813 0.85 0.694 0.747 0.857 0.889 2.854 3.066 77.613 132.824
Mouse 12 (78) 0.69 0.864 0.6 0.767 0.723 0.898 2.329 3.273 62.253 378.367

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Non-Methyl HT-SELEX, 2 experiments median 0.669 0.639 0.6 0.586 0.554 0.554
best 0.699 0.668 0.615 0.603 0.561 0.563

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.652 0.31 0.539 0.351
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classFork head/winged helix factors {3.3} (TFClass)
TF familyFOX {3.3.1} (TFClass)
TF subfamilyFOXO {3.3.1.15} (TFClass)
TFClass IDTFClass: 3.3.1.15.1
HGNCHGNC:3819
MGIMGI:1890077
EntrezGene (human)GeneID:2308
(SSTAR profile)
EntrezGene (mouse)GeneID:56458
(SSTAR profile)
UniProt ID (human)FOXO1_HUMAN
UniProt ID (mouse)FOXO1_MOUSE
UniProt AC (human)Q12778
(TFClass)
UniProt AC (mouse)Q9R1E0
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 3 human, 12 mouse
HT-SELEX 2
Methyl-HT-SELEX 0
PCM
ACGT
0161.0354.0232.0352.0
0212.02.03.0982.0
0344.014.0919.022.0
043.07.09.0980.0
052.04.073.0920.0
063.09.0219.0768.0
07597.0166.035.0201.0
0810.0754.025.0210.0
09302.0292.0168.0237.0
PFM
ACGT
010.0610.3540.2320.352
020.0120.0020.0030.983
030.0440.0140.920.022
040.0030.0070.0090.981
050.0020.0040.0730.921
060.0030.0090.2190.769
070.5980.1660.0350.201
080.010.7550.0250.21
090.3020.2920.1680.237
PWM
ACGT
01-1.3890.347-0.0730.341
02-2.908-4.212-3.9741.364
03-1.705-2.7721.298-2.361
04-3.974-3.361-3.1551.362
05-4.212-3.782-1.2141.299
06-3.974-3.155-0.131.119
070.867-0.405-1.924-0.215
08-3.0651.1-2.242-0.172
090.1890.155-0.393-0.052
Standard thresholds
P-value Threshold
0.001 4.74332
0.0005 5.910945
0.0001 7.633735