FOXG1.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	FOXG1.H12INVIVO.0.PSM.A
Gene (human)	FOXG1 (GeneCards)
Gene synonyms (human)	FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C
Gene (mouse)	Foxg1
Gene synonyms (mouse)	Fkhl1, Foxg1b, Hfhbf1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	15
Consensus	bbbTGTTTdYhhdvh
GC content	41.4%
Information content (bits; total / per base)	9.953 / 0.664
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	1007

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	3 (17)	0.777	0.825	0.63	0.675	0.797	0.852	2.368	2.728	139.119	210.319

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.82	0.758	0.77	0.712	0.704	0.664
Overall, 3 experiments	best	0.901	0.854	0.863	0.81	0.808	0.76
Methyl HT-SELEX, 1 experiments	median	0.901	0.854	0.863	0.81	0.808	0.76
Methyl HT-SELEX, 1 experiments	best	0.901	0.854	0.863	0.81	0.808	0.76
Non-Methyl HT-SELEX, 2 experiments	median	0.687	0.647	0.653	0.618	0.612	0.59
Non-Methyl HT-SELEX, 2 experiments	best	0.82	0.758	0.77	0.712	0.704	0.664

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	FOX {3.3.1} (TFClass)
TF subfamily	FOXG {3.3.1.7} (TFClass)
TFClass ID	TFClass: 3.3.1.7.1
HGNC	HGNC:3811
MGI	MGI:1347464
EntrezGene (human)	GeneID:2290 (SSTAR profile)
EntrezGene (mouse)	GeneID:15228 (SSTAR profile)
UniProt ID (human)	FOXG1_HUMAN
UniProt ID (mouse)	FOXG1_MOUSE
UniProt AC (human)	P55316 (TFClass)
UniProt AC (mouse)	Q60987 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 3 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	FOXG1.H12INVIVO.0.PSM.A.pcm
PWM	FOXG1.H12INVIVO.0.PSM.A.pwm
PFM	FOXG1.H12INVIVO.0.PSM.A.pfm
Alignment	FOXG1.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	FOXG1.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	FOXG1.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	FOXG1.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	FOXG1.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	FOXG1.H12INVIVO.0.PSM.A_homer_format_0.001.txt FOXG1.H12INVIVO.0.PSM.A_homer_format_0.0005.txt FOXG1.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	115.0	341.0	257.0	294.0
02	134.0	192.0	224.0	457.0
03	110.0	253.0	353.0	291.0
04	7.0	0.0	1.0	999.0
05	33.0	1.0	973.0	0.0
06	0.0	7.0	2.0	998.0
07	1.0	7.0	83.0	916.0
08	2.0	7.0	203.0	795.0
09	343.0	83.0	308.0	273.0
10	27.0	579.0	173.0	228.0
11	484.0	223.0	87.0	213.0
12	182.0	385.0	162.0	278.0
13	445.0	148.0	182.0	232.0
14	225.0	405.0	216.0	161.0
15	390.0	256.0	143.0	218.0

PFM

	A	C	G	T
01	0.114	0.339	0.255	0.292
02	0.133	0.191	0.222	0.454
03	0.109	0.251	0.351	0.289
04	0.007	0.0	0.001	0.992
05	0.033	0.001	0.966	0.0
06	0.0	0.007	0.002	0.991
07	0.001	0.007	0.082	0.91
08	0.002	0.007	0.202	0.789
09	0.341	0.082	0.306	0.271
10	0.027	0.575	0.172	0.226
11	0.481	0.221	0.086	0.212
12	0.181	0.382	0.161	0.276
13	0.442	0.147	0.181	0.23
14	0.223	0.402	0.214	0.16
15	0.387	0.254	0.142	0.216

PWM

	A	C	G	T
01	-0.775	0.302	0.021	0.154
02	-0.625	-0.269	-0.116	0.593
03	-0.819	0.005	0.336	0.144
04	-3.369	-4.988	-4.531	1.373
05	-1.988	-4.531	1.347	-4.988
06	-4.988	-3.369	-4.219	1.372
07	-4.531	-3.369	-1.096	1.287
08	-4.219	-3.369	-0.214	1.145
09	0.307	-1.096	0.2	0.081
10	-2.177	0.829	-0.372	-0.098
11	0.65	-0.12	-1.05	-0.166
12	-0.322	0.422	-0.437	0.099
13	0.567	-0.526	-0.322	-0.081
14	-0.112	0.473	-0.152	-0.443
15	0.435	0.017	-0.56	-0.143

Standard thresholds

P-value	Threshold
0.001	4.95716
0.0005	5.92401
0.0001	7.48981