FOXE1.H12RSNP.1.S.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	FOXE1.H12RSNP.1.S.C
Gene (human)	FOXE1 (GeneCards)
Gene synonyms (human)	FKHL15, FOXE2, TITF2, TTF2
Gene (mouse)	Foxe1
Gene synonyms (mouse)	Titf2
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	C

Motif length	11
Consensus	dbdTTGTTWdn
GC content	28.57%
Information content (bits; total / per base)	11.613 / 1.056
Data sources	HT-SELEX
Aligned words	6146

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.937	0.897	0.882	0.844	0.795	0.769
Overall, 2 experiments	best	0.942	0.898	0.908	0.866	0.85	0.809
Methyl HT-SELEX, 1 experiments	median	0.932	0.895	0.856	0.822	0.739	0.729
Methyl HT-SELEX, 1 experiments	best	0.932	0.895	0.856	0.822	0.739	0.729
Non-Methyl HT-SELEX, 1 experiments	median	0.942	0.898	0.908	0.866	0.85	0.809
Non-Methyl HT-SELEX, 1 experiments	best	0.942	0.898	0.908	0.866	0.85	0.809

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.708	0.438	0.643	0.486

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	FOX {3.3.1} (TFClass)
TF subfamily	FOXE {3.3.1.5} (TFClass)
TFClass ID	TFClass: 3.3.1.5.1
HGNC	HGNC:3806
MGI	MGI:1353500
EntrezGene (human)	GeneID:2304 (SSTAR profile)
EntrezGene (mouse)	GeneID:110805 (SSTAR profile)
UniProt ID (human)	FOXE1_HUMAN
UniProt ID (mouse)	FOXE1_MOUSE
UniProt AC (human)	O00358 (TFClass)
UniProt AC (mouse)	Q8R2I0 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	FOXE1.H12RSNP.1.S.C.pcm
PWM	FOXE1.H12RSNP.1.S.C.pwm
PFM	FOXE1.H12RSNP.1.S.C.pfm
Alignment	FOXE1.H12RSNP.1.S.C.words.tsv
Threshold to P-value map	FOXE1.H12RSNP.1.S.C.thr
Motif in other formats
JASPAR format	FOXE1.H12RSNP.1.S.C_jaspar_format.txt
MEME format	FOXE1.H12RSNP.1.S.C_meme_format.meme
Transfac format	FOXE1.H12RSNP.1.S.C_transfac_format.txt
Homer format	FOXE1.H12RSNP.1.S.C_homer_format_0.001.txt FOXE1.H12RSNP.1.S.C_homer_format_0.0005.txt FOXE1.H12RSNP.1.S.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1071.75	1048.75	1560.75	2464.75
02	395.25	1361.25	1824.25	2565.25
03	1365.0	623.0	2498.0	1660.0
04	95.0	0.0	15.0	6036.0
05	0.0	0.0	0.0	6146.0
06	0.0	0.0	6146.0	0.0
07	0.0	0.0	0.0	6146.0
08	0.0	0.0	0.0	6146.0
09	1353.0	0.0	317.0	4476.0
10	1821.0	498.0	929.0	2898.0
11	1271.0	1143.0	1354.0	2378.0

PFM

	A	C	G	T
01	0.174	0.171	0.254	0.401
02	0.064	0.221	0.297	0.417
03	0.222	0.101	0.406	0.27
04	0.015	0.0	0.002	0.982
05	0.0	0.0	0.0	1.0
06	0.0	0.0	1.0	0.0
07	0.0	0.0	0.0	1.0
08	0.0	0.0	0.0	1.0
09	0.22	0.0	0.052	0.728
10	0.296	0.081	0.151	0.472
11	0.207	0.186	0.22	0.387

PWM

	A	C	G	T
01	-0.36	-0.381	0.016	0.472
02	-1.354	-0.121	0.171	0.512
03	-0.118	-0.901	0.485	0.077
04	-2.762	-6.559	-4.495	1.367
05	-6.559	-6.559	-6.559	1.385
06	-6.559	-6.559	1.385	-6.559
07	-6.559	-6.559	-6.559	1.385
08	-6.559	-6.559	-6.559	1.385
09	-0.127	-6.559	-1.573	1.068
10	0.17	-1.124	-0.502	0.634
11	-0.189	-0.295	-0.126	0.436

Standard thresholds

P-value	Threshold
0.001	2.743805
0.0005	5.333725
0.0001	7.892175