FOXE1.H12RSNP.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	FOXE1.H12RSNP.0.SM.B
Gene (human)	FOXE1 (GeneCards)
Gene synonyms (human)	FKHL15, FOXE2, TITF2, TTF2
Gene (mouse)	Foxe1
Gene synonyms (mouse)	Titf2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	20
Consensus	nddbdTTGTTKKKWTARbdn
GC content	35.51%
Information content (bits; total / per base)	16.112 / 0.806
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	451

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.967	0.949	0.899	0.878	0.768	0.769
Overall, 2 experiments	best	0.978	0.969	0.906	0.881	0.809	0.789
Methyl HT-SELEX, 1 experiments	median	0.978	0.969	0.893	0.881	0.728	0.748
Methyl HT-SELEX, 1 experiments	best	0.978	0.969	0.893	0.881	0.728	0.748
Non-Methyl HT-SELEX, 1 experiments	median	0.955	0.93	0.906	0.875	0.809	0.789
Non-Methyl HT-SELEX, 1 experiments	best	0.955	0.93	0.906	0.875	0.809	0.789

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.893	0.761	0.858	0.597

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	FOX {3.3.1} (TFClass)
TF subfamily	FOXE {3.3.1.5} (TFClass)
TFClass ID	TFClass: 3.3.1.5.1
HGNC	HGNC:3806
MGI	MGI:1353500
EntrezGene (human)	GeneID:2304 (SSTAR profile)
EntrezGene (mouse)	GeneID:110805 (SSTAR profile)
UniProt ID (human)	FOXE1_HUMAN
UniProt ID (mouse)	FOXE1_MOUSE
UniProt AC (human)	O00358 (TFClass)
UniProt AC (mouse)	Q8R2I0 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	FOXE1.H12RSNP.0.SM.B.pcm
PWM	FOXE1.H12RSNP.0.SM.B.pwm
PFM	FOXE1.H12RSNP.0.SM.B.pfm
Alignment	FOXE1.H12RSNP.0.SM.B.words.tsv
Threshold to P-value map	FOXE1.H12RSNP.0.SM.B.thr
Motif in other formats
JASPAR format	FOXE1.H12RSNP.0.SM.B_jaspar_format.txt
MEME format	FOXE1.H12RSNP.0.SM.B_meme_format.meme
Transfac format	FOXE1.H12RSNP.0.SM.B_transfac_format.txt
Homer format	FOXE1.H12RSNP.0.SM.B_homer_format_0.001.txt FOXE1.H12RSNP.0.SM.B_homer_format_0.0005.txt FOXE1.H12RSNP.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	91.5	74.5	143.5	141.5
02	92.25	66.25	175.25	117.25
03	79.0	51.0	143.0	178.0
04	21.0	103.0	160.0	167.0
05	160.0	39.0	155.0	97.0
06	44.0	5.0	23.0	379.0
07	1.0	3.0	0.0	447.0
08	6.0	0.0	445.0	0.0
09	0.0	2.0	0.0	449.0
10	0.0	0.0	3.0	448.0
11	103.0	0.0	127.0	221.0
12	66.0	0.0	135.0	250.0
13	9.0	37.0	91.0	314.0
14	127.0	6.0	48.0	270.0
15	9.0	20.0	7.0	415.0
16	349.0	4.0	12.0	86.0
17	216.0	5.0	210.0	20.0
18	19.0	94.0	249.0	89.0
19	59.5	53.5	267.5	70.5
20	92.25	103.25	142.25	113.25

PFM

	A	C	G	T
01	0.203	0.165	0.318	0.314
02	0.205	0.147	0.389	0.26
03	0.175	0.113	0.317	0.395
04	0.047	0.228	0.355	0.37
05	0.355	0.086	0.344	0.215
06	0.098	0.011	0.051	0.84
07	0.002	0.007	0.0	0.991
08	0.013	0.0	0.987	0.0
09	0.0	0.004	0.0	0.996
10	0.0	0.0	0.007	0.993
11	0.228	0.0	0.282	0.49
12	0.146	0.0	0.299	0.554
13	0.02	0.082	0.202	0.696
14	0.282	0.013	0.106	0.599
15	0.02	0.044	0.016	0.92
16	0.774	0.009	0.027	0.191
17	0.479	0.011	0.466	0.044
18	0.042	0.208	0.552	0.197
19	0.132	0.119	0.593	0.156
20	0.205	0.229	0.315	0.251

PWM

	A	C	G	T
01	-0.206	-0.408	0.238	0.224
02	-0.198	-0.522	0.436	0.039
03	-0.35	-0.777	0.235	0.452
04	-1.624	-0.089	0.346	0.388
05	0.346	-1.037	0.315	-0.148
06	-0.92	-2.863	-1.539	1.203
07	-3.811	-3.228	-4.315	1.367
08	-2.72	-4.315	1.363	-4.315
09	-4.315	-3.478	-4.315	1.372
10	-4.315	-4.315	-3.228	1.37
11	-0.089	-4.315	0.118	0.666
12	-0.526	-4.315	0.178	0.789
13	-2.385	-1.087	-0.211	1.016
14	0.118	-2.72	-0.836	0.865
15	-2.385	-1.669	-2.595	1.293
16	1.121	-3.029	-2.134	-0.267
17	0.644	-2.863	0.616	-1.669
18	-1.717	-0.179	0.785	-0.233
19	-0.627	-0.731	0.856	-0.462
20	-0.198	-0.087	0.23	0.004

Standard thresholds

P-value	Threshold
0.001	2.34251
0.0005	3.63271
0.0001	6.31461