FOXE1.H12CORE.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	FOXE1.H12CORE.0.SM.B
Gene (human)	FOXE1 (GeneCards)
Gene synonyms (human)	FKHL15, FOXE2, TITF2, TTF2
Gene (mouse)	Foxe1
Gene synonyms (mouse)	Titf2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	16
Consensus	nWTGTTKKYWTARbvn
GC content	32.85%
Information content (bits; total / per base)	14.467 / 0.904
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	7750

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.982	0.972	0.951	0.935	0.837	0.833
Overall, 2 experiments	best	0.995	0.992	0.971	0.965	0.84	0.845
Methyl HT-SELEX, 1 experiments	median	0.995	0.992	0.971	0.965	0.835	0.845
Methyl HT-SELEX, 1 experiments	best	0.995	0.992	0.971	0.965	0.835	0.845
Non-Methyl HT-SELEX, 1 experiments	median	0.97	0.953	0.931	0.906	0.84	0.821
Non-Methyl HT-SELEX, 1 experiments	best	0.97	0.953	0.931	0.906	0.84	0.821

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.883	0.741	0.808	0.508

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	FOX {3.3.1} (TFClass)
TF subfamily	FOXE {3.3.1.5} (TFClass)
TFClass ID	TFClass: 3.3.1.5.1
HGNC	HGNC:3806
MGI	MGI:1353500
EntrezGene (human)	GeneID:2304 (SSTAR profile)
EntrezGene (mouse)	GeneID:110805 (SSTAR profile)
UniProt ID (human)	FOXE1_HUMAN
UniProt ID (mouse)	FOXE1_MOUSE
UniProt AC (human)	O00358 (TFClass)
UniProt AC (mouse)	Q8R2I0 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	FOXE1.H12CORE.0.SM.B.pcm
PWM	FOXE1.H12CORE.0.SM.B.pwm
PFM	FOXE1.H12CORE.0.SM.B.pfm
Alignment	FOXE1.H12CORE.0.SM.B.words.tsv
Threshold to P-value map	FOXE1.H12CORE.0.SM.B.thr
Motif in other formats
JASPAR format	FOXE1.H12CORE.0.SM.B_jaspar_format.txt
MEME format	FOXE1.H12CORE.0.SM.B_meme_format.meme
Transfac format	FOXE1.H12CORE.0.SM.B_transfac_format.txt
Homer format	FOXE1.H12CORE.0.SM.B_homer_format_0.001.txt FOXE1.H12CORE.0.SM.B_homer_format_0.0005.txt FOXE1.H12CORE.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2415.25	1062.25	2225.25	2047.25
02	1158.25	432.25	959.25	5200.25
03	21.0	101.0	22.0	7606.0
04	70.0	3.0	7676.0	1.0
05	2.0	138.0	16.0	7594.0
06	13.0	9.0	205.0	7523.0
07	2027.0	2.0	2165.0	3556.0
08	1578.0	13.0	1777.0	4382.0
09	30.0	1170.0	1165.0	5385.0
10	2337.0	232.0	999.0	4182.0
11	67.0	439.0	151.0	7093.0
12	6077.0	16.0	123.0	1534.0
13	3616.0	54.0	3833.0	247.0
14	328.0	1729.0	3983.0	1710.0
15	1104.75	1251.75	4530.75	862.75
16	1533.25	2050.25	2197.25	1969.25

PFM

	A	C	G	T
01	0.312	0.137	0.287	0.264
02	0.149	0.056	0.124	0.671
03	0.003	0.013	0.003	0.981
04	0.009	0.0	0.99	0.0
05	0.0	0.018	0.002	0.98
06	0.002	0.001	0.026	0.971
07	0.262	0.0	0.279	0.459
08	0.204	0.002	0.229	0.565
09	0.004	0.151	0.15	0.695
10	0.302	0.03	0.129	0.54
11	0.009	0.057	0.019	0.915
12	0.784	0.002	0.016	0.198
13	0.467	0.007	0.495	0.032
14	0.042	0.223	0.514	0.221
15	0.143	0.162	0.585	0.111
16	0.198	0.265	0.284	0.254

PWM

	A	C	G	T
01	0.22	-0.6	0.138	0.055
02	-0.514	-1.496	-0.702	0.987
03	-4.424	-2.933	-4.382	1.367
04	-3.29	-5.914	1.376	-6.395
05	-6.126	-2.627	-4.667	1.365
06	-4.846	-5.151	-2.236	1.356
07	0.045	-6.126	0.111	0.607
08	-0.205	-4.846	-0.086	0.815
09	-4.097	-0.504	-0.508	1.021
10	0.187	-2.114	-0.661	0.769
11	-3.333	-1.481	-2.538	1.297
12	1.142	-4.667	-2.74	-0.233
13	0.623	-3.541	0.682	-2.052
14	-1.77	-0.114	0.72	-0.125
15	-0.561	-0.436	0.849	-0.808
16	-0.234	0.056	0.126	0.016

Standard thresholds

P-value	Threshold
0.001	2.59376
0.0005	3.93101
0.0001	6.64516