| Motif | FOXA3.H12RSNP.1.M.C |
| Gene (human) | FOXA3 (GeneCards) |
| Gene synonyms (human) | HNF3G, TCF3G |
| Gene (mouse) | Foxa3 |
| Gene synonyms (mouse) | Hnf3g, Tcf-3g, Tcf3g |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 1 |
| Quality | C |
| Motif | FOXA3.H12RSNP.1.M.C |
| Gene (human) | FOXA3 (GeneCards) |
| Gene synonyms (human) | HNF3G, TCF3G |
| Gene (mouse) | Foxa3 |
| Gene synonyms (mouse) | Hnf3g, Tcf-3g, Tcf3g |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 1 |
| Quality | C |
| Motif length | 19 |
| Consensus | nvbMMWTRTTKRChYWvbn |
| GC content | 36.7% |
| Information content (bits; total / per base) | 13.651 / 0.718 |
| Data sources | Methyl-HT-SELEX |
| Aligned words | 4338 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 1 (7) | 0.789 | 0.812 | 0.66 | 0.697 | 0.806 | 0.834 | 2.793 | 3.023 | 146.071 | 170.161 |
| Mouse | 2 (14) | 0.743 | 0.805 | 0.605 | 0.667 | 0.753 | 0.804 | 2.357 | 2.569 | 155.799 | 266.041 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 2 experiments | median | 0.836 | 0.837 | 0.75 | 0.75 | 0.645 | 0.66 |
| best | 0.986 | 0.982 | 0.902 | 0.896 | 0.732 | 0.756 | |
| Methyl HT-SELEX, 1 experiments | median | 0.685 | 0.691 | 0.599 | 0.605 | 0.559 | 0.565 |
| best | 0.685 | 0.691 | 0.599 | 0.605 | 0.559 | 0.565 | |
| Non-Methyl HT-SELEX, 1 experiments | median | 0.986 | 0.982 | 0.902 | 0.896 | 0.732 | 0.756 |
| best | 0.986 | 0.982 | 0.902 | 0.896 | 0.732 | 0.756 | |
| rSNP benchmarking, ADASTRA | odds-ratio | -log-Fisher's P | Pearson r | Kendall tau |
|---|---|---|---|---|
| # | 10.0 | 3.025 | 0.21 | 0.19 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Fork head/winged helix factors {3.3} (TFClass) |
| TF family | FOX {3.3.1} (TFClass) |
| TF subfamily | FOXA {3.3.1.1} (TFClass) |
| TFClass ID | TFClass: 3.3.1.1.3 |
| HGNC | HGNC:5023 |
| MGI | MGI:1347477 |
| EntrezGene (human) | GeneID:3171 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:15377 (SSTAR profile) |
| UniProt ID (human) | FOXA3_HUMAN |
| UniProt ID (mouse) | FOXA3_MOUSE |
| UniProt AC (human) | P55318 (TFClass) |
| UniProt AC (mouse) | P35584 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 1 human, 2 mouse |
| HT-SELEX | 1 |
| Methyl-HT-SELEX | 1 |
| PCM | FOXA3.H12RSNP.1.M.C.pcm |
| PWM | FOXA3.H12RSNP.1.M.C.pwm |
| PFM | FOXA3.H12RSNP.1.M.C.pfm |
| Alignment | FOXA3.H12RSNP.1.M.C.words.tsv |
| Threshold to P-value map | FOXA3.H12RSNP.1.M.C.thr |
| Motif in other formats | |
| JASPAR format | FOXA3.H12RSNP.1.M.C_jaspar_format.txt |
| MEME format | FOXA3.H12RSNP.1.M.C_meme_format.meme |
| Transfac format | FOXA3.H12RSNP.1.M.C_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 1153.5 | 1022.5 | 889.5 | 1272.5 |
| 02 | 657.75 | 697.75 | 2540.75 | 441.75 |
| 03 | 263.0 | 1994.0 | 367.0 | 1714.0 |
| 04 | 2310.0 | 1357.0 | 330.0 | 341.0 |
| 05 | 3045.0 | 576.0 | 150.0 | 567.0 |
| 06 | 3134.0 | 422.0 | 111.0 | 671.0 |
| 07 | 15.0 | 559.0 | 6.0 | 3758.0 |
| 08 | 3200.0 | 416.0 | 722.0 | 0.0 |
| 09 | 1.0 | 337.0 | 1.0 | 3999.0 |
| 10 | 1.0 | 24.0 | 8.0 | 4305.0 |
| 11 | 32.0 | 464.0 | 709.0 | 3133.0 |
| 12 | 3118.0 | 456.0 | 760.0 | 4.0 |
| 13 | 44.0 | 4088.0 | 22.0 | 184.0 |
| 14 | 1690.0 | 627.0 | 282.0 | 1739.0 |
| 15 | 220.0 | 1853.0 | 97.0 | 2168.0 |
| 16 | 2667.0 | 535.0 | 136.0 | 1000.0 |
| 17 | 1692.0 | 903.0 | 1164.0 | 579.0 |
| 18 | 525.25 | 1938.25 | 998.25 | 876.25 |
| 19 | 966.25 | 1328.25 | 1359.25 | 684.25 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.266 | 0.236 | 0.205 | 0.293 |
| 02 | 0.152 | 0.161 | 0.586 | 0.102 |
| 03 | 0.061 | 0.46 | 0.085 | 0.395 |
| 04 | 0.533 | 0.313 | 0.076 | 0.079 |
| 05 | 0.702 | 0.133 | 0.035 | 0.131 |
| 06 | 0.722 | 0.097 | 0.026 | 0.155 |
| 07 | 0.003 | 0.129 | 0.001 | 0.866 |
| 08 | 0.738 | 0.096 | 0.166 | 0.0 |
| 09 | 0.0 | 0.078 | 0.0 | 0.922 |
| 10 | 0.0 | 0.006 | 0.002 | 0.992 |
| 11 | 0.007 | 0.107 | 0.163 | 0.722 |
| 12 | 0.719 | 0.105 | 0.175 | 0.001 |
| 13 | 0.01 | 0.942 | 0.005 | 0.042 |
| 14 | 0.39 | 0.145 | 0.065 | 0.401 |
| 15 | 0.051 | 0.427 | 0.022 | 0.5 |
| 16 | 0.615 | 0.123 | 0.031 | 0.231 |
| 17 | 0.39 | 0.208 | 0.268 | 0.133 |
| 18 | 0.121 | 0.447 | 0.23 | 0.202 |
| 19 | 0.223 | 0.306 | 0.313 | 0.158 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.062 | -0.059 | -0.198 | 0.16 |
| 02 | -0.499 | -0.44 | 0.85 | -0.895 |
| 03 | -1.411 | 0.608 | -1.08 | 0.457 |
| 04 | 0.755 | 0.224 | -1.185 | -1.153 |
| 05 | 1.031 | -0.631 | -1.966 | -0.647 |
| 06 | 1.06 | -0.941 | -2.263 | -0.479 |
| 07 | -4.152 | -0.661 | -4.9 | 1.241 |
| 08 | 1.081 | -0.955 | -0.406 | -6.252 |
| 09 | -5.861 | -1.165 | -5.861 | 1.304 |
| 10 | -5.861 | -3.729 | -4.679 | 1.377 |
| 11 | -3.462 | -0.846 | -0.424 | 1.06 |
| 12 | 1.055 | -0.864 | -0.355 | -5.184 |
| 13 | -3.16 | 1.326 | -3.809 | -1.765 |
| 14 | 0.443 | -0.547 | -1.341 | 0.471 |
| 15 | -1.588 | 0.535 | -2.395 | 0.692 |
| 16 | 0.899 | -0.705 | -2.063 | -0.081 |
| 17 | 0.444 | -0.183 | 0.071 | -0.626 |
| 18 | -0.723 | 0.58 | -0.083 | -0.213 |
| 19 | -0.115 | 0.202 | 0.225 | -0.459 |
| P-value | Threshold |
|---|---|
| 0.001 | 3.51796 |
| 0.0005 | 4.65536 |
| 0.0001 | 6.93911 |