MotifFOXA3.H12INVITRO.1.M.C
Gene (human)FOXA3
(GeneCards)
Gene synonyms (human)HNF3G, TCF3G
Gene (mouse)Foxa3
Gene synonyms (mouse)Hnf3g, Tcf-3g, Tcf3g
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
C
Motif length19
ConsensusnvbMMWTRTTKRChYWvbn
GC content36.7%
Information content (bits; total / per base)13.651 / 0.718
Data sourcesMethyl-HT-SELEX
Aligned words4338

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 1 (7) 0.789 0.812 0.66 0.697 0.806 0.834 2.793 3.023 146.071 170.161
Mouse 2 (14) 0.743 0.805 0.605 0.667 0.753 0.804 2.357 2.569 155.799 266.041

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 2 experiments median 0.836 0.837 0.75 0.75 0.645 0.66
best 0.986 0.982 0.902 0.896 0.732 0.756
Methyl HT-SELEX, 1 experiments median 0.685 0.691 0.599 0.605 0.559 0.565
best 0.685 0.691 0.599 0.605 0.559 0.565
Non-Methyl HT-SELEX, 1 experiments median 0.986 0.982 0.902 0.896 0.732 0.756
best 0.986 0.982 0.902 0.896 0.732 0.756

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 10.0 3.025 0.21 0.19
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classFork head/winged helix factors {3.3} (TFClass)
TF familyFOX {3.3.1} (TFClass)
TF subfamilyFOXA {3.3.1.1} (TFClass)
TFClass IDTFClass: 3.3.1.1.3
HGNCHGNC:5023
MGIMGI:1347477
EntrezGene (human)GeneID:3171
(SSTAR profile)
EntrezGene (mouse)GeneID:15377
(SSTAR profile)
UniProt ID (human)FOXA3_HUMAN
UniProt ID (mouse)FOXA3_MOUSE
UniProt AC (human)P55318
(TFClass)
UniProt AC (mouse)P35584
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 1 human, 2 mouse
HT-SELEX 1
Methyl-HT-SELEX 1
PCM
ACGT
011153.51022.5889.51272.5
02657.75697.752540.75441.75
03263.01994.0367.01714.0
042310.01357.0330.0341.0
053045.0576.0150.0567.0
063134.0422.0111.0671.0
0715.0559.06.03758.0
083200.0416.0722.00.0
091.0337.01.03999.0
101.024.08.04305.0
1132.0464.0709.03133.0
123118.0456.0760.04.0
1344.04088.022.0184.0
141690.0627.0282.01739.0
15220.01853.097.02168.0
162667.0535.0136.01000.0
171692.0903.01164.0579.0
18525.251938.25998.25876.25
19966.251328.251359.25684.25
PFM
ACGT
010.2660.2360.2050.293
020.1520.1610.5860.102
030.0610.460.0850.395
040.5330.3130.0760.079
050.7020.1330.0350.131
060.7220.0970.0260.155
070.0030.1290.0010.866
080.7380.0960.1660.0
090.00.0780.00.922
100.00.0060.0020.992
110.0070.1070.1630.722
120.7190.1050.1750.001
130.010.9420.0050.042
140.390.1450.0650.401
150.0510.4270.0220.5
160.6150.1230.0310.231
170.390.2080.2680.133
180.1210.4470.230.202
190.2230.3060.3130.158
PWM
ACGT
010.062-0.059-0.1980.16
02-0.499-0.440.85-0.895
03-1.4110.608-1.080.457
040.7550.224-1.185-1.153
051.031-0.631-1.966-0.647
061.06-0.941-2.263-0.479
07-4.152-0.661-4.91.241
081.081-0.955-0.406-6.252
09-5.861-1.165-5.8611.304
10-5.861-3.729-4.6791.377
11-3.462-0.846-0.4241.06
121.055-0.864-0.355-5.184
13-3.161.326-3.809-1.765
140.443-0.547-1.3410.471
15-1.5880.535-2.3950.692
160.899-0.705-2.063-0.081
170.444-0.1830.071-0.626
18-0.7230.58-0.083-0.213
19-0.1150.2020.225-0.459
Standard thresholds
P-value Threshold
0.001 3.51796
0.0005 4.65536
0.0001 6.93911