MotifFOXA2.H12RSNP.1.SM.B
Gene (human)FOXA2
(GeneCards)
Gene synonyms (human)HNF3B, TCF3B
Gene (mouse)Foxa2
Gene synonyms (mouse)Hnf3b, Tcf-3b, Tcf3b
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length16
ConsensusdYMAATATTTAChYWn
GC content28.52%
Information content (bits; total / per base)17.643 / 1.103
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words5603

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 54 (310) 0.752 0.83 0.576 0.683 0.748 0.874 2.307 3.059 46.502 130.538
Mouse 20 (114) 0.741 0.822 0.569 0.68 0.685 0.816 1.982 3.027 53.571 130.854

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 2 experiments median 0.983 0.977 0.941 0.925 0.866 0.847
best 0.994 0.993 0.955 0.946 0.874 0.862
Methyl HT-SELEX, 1 experiments median 0.994 0.993 0.955 0.946 0.874 0.862
best 0.994 0.993 0.955 0.946 0.874 0.862
Non-Methyl HT-SELEX, 1 experiments median 0.972 0.961 0.926 0.904 0.858 0.833
best 0.972 0.961 0.926 0.904 0.858 0.833

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 6.437 29.025 0.236 0.215

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.906 0.367 0.878 0.521
batch 2 0.7 0.124 0.761 0.548
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classFork head/winged helix factors {3.3} (TFClass)
TF familyFOX {3.3.1} (TFClass)
TF subfamilyFOXA {3.3.1.1} (TFClass)
TFClass IDTFClass: 3.3.1.1.2
HGNCHGNC:5022
MGIMGI:1347476
EntrezGene (human)GeneID:3170
(SSTAR profile)
EntrezGene (mouse)GeneID:15376
(SSTAR profile)
UniProt ID (human)FOXA2_HUMAN
UniProt ID (mouse)FOXA2_MOUSE
UniProt AC (human)Q9Y261
(TFClass)
UniProt AC (mouse)P35583
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 54 human, 20 mouse
HT-SELEX 1
Methyl-HT-SELEX 1
PCM
ACGT
011338.75536.752979.75747.75
02226.02545.0117.02715.0
033207.02026.0120.0250.0
045227.0220.065.091.0
055410.0103.036.054.0
060.060.00.05543.0
075371.00.0232.00.0
080.00.00.05603.0
090.01.08.05594.0
103.01.02155.03444.0
114382.04.01216.01.0
1297.05183.025.0298.0
132649.0639.0588.01727.0
14314.02498.0394.02397.0
153012.25177.25600.251813.25
161407.251188.251849.251158.25
PFM
ACGT
010.2390.0960.5320.133
020.040.4540.0210.485
030.5720.3620.0210.045
040.9330.0390.0120.016
050.9660.0180.0060.01
060.00.0110.00.989
070.9590.00.0410.0
080.00.00.01.0
090.00.00.0010.998
100.0010.00.3850.615
110.7820.0010.2170.0
120.0170.9250.0040.053
130.4730.1140.1050.308
140.0560.4460.070.428
150.5380.0320.1070.324
160.2510.2120.330.207
PWM
ACGT
01-0.045-0.9570.754-0.626
02-1.8160.596-2.4660.661
030.8270.369-2.441-1.716
041.316-1.843-3.039-2.712
051.35-2.591-3.605-3.218
06-6.477-3.117-6.4771.374
071.343-6.477-1.79-6.477
08-6.477-6.477-6.4771.385
09-6.477-6.096-4.9281.384
10-5.606-6.0960.430.899
111.139-5.429-0.141-6.096
12-2.651.307-3.945-1.542
130.636-0.783-0.8660.209
14-1.490.578-1.2640.537
150.765-2.057-0.8450.258
160.005-0.1640.277-0.19
Standard thresholds
P-value Threshold
0.001 -0.20434
0.0005 1.50046
0.0001 5.00951