MotifFOXA2.H12INVIVO.1.SM.B
Gene (human)FOXA2
(GeneCards)
Gene synonyms (human)HNF3B, TCF3B
Gene (mouse)Foxa2
Gene synonyms (mouse)Hnf3b, Tcf-3b, Tcf3b
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length16
ConsensusnvYMAATATTTAChhn
GC content31.28%
Information content (bits; total / per base)15.872 / 0.992
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words967

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 54 (310) 0.803 0.871 0.628 0.737 0.8 0.888 2.512 3.143 88.854 233.041
Mouse 20 (114) 0.795 0.86 0.62 0.722 0.755 0.856 2.222 3.162 102.639 212.886

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 2 experiments median 0.982 0.975 0.953 0.937 0.889 0.869
best 0.993 0.991 0.965 0.955 0.889 0.878
Methyl HT-SELEX, 1 experiments median 0.993 0.991 0.965 0.955 0.889 0.878
best 0.993 0.991 0.965 0.955 0.889 0.878
Non-Methyl HT-SELEX, 1 experiments median 0.972 0.96 0.942 0.919 0.888 0.861
best 0.972 0.96 0.942 0.919 0.888 0.861

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 4.142 18.881 0.226 0.202

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.915 0.441 0.903 0.547
batch 2 0.672 0.069 0.781 0.559
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classFork head/winged helix factors {3.3} (TFClass)
TF familyFOX {3.3.1} (TFClass)
TF subfamilyFOXA {3.3.1.1} (TFClass)
TFClass IDTFClass: 3.3.1.1.2
HGNCHGNC:5022
MGIMGI:1347476
EntrezGene (human)GeneID:3170
(SSTAR profile)
EntrezGene (mouse)GeneID:15376
(SSTAR profile)
UniProt ID (human)FOXA2_HUMAN
UniProt ID (mouse)FOXA2_MOUSE
UniProt AC (human)Q9Y261
(TFClass)
UniProt AC (mouse)P35583
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 54 human, 20 mouse
HT-SELEX 1
Methyl-HT-SELEX 1
PCM
ACGT
01230.25213.25225.25298.25
02202.25118.25529.25117.25
0341.0307.060.0559.0
04371.0479.065.052.0
05805.054.025.083.0
06869.013.09.076.0
070.00.00.0967.0
08779.00.0188.00.0
090.00.00.0967.0
100.00.00.0967.0
110.00.0127.0840.0
12656.00.0311.00.0
136.0911.02.048.0
14286.0231.0120.0330.0
1592.5442.577.5354.5
16311.5148.5182.5324.5
PFM
ACGT
010.2380.2210.2330.308
020.2090.1220.5470.121
030.0420.3170.0620.578
040.3840.4950.0670.054
050.8320.0560.0260.086
060.8990.0130.0090.079
070.00.00.01.0
080.8060.00.1940.0
090.00.00.01.0
100.00.00.01.0
110.00.00.1310.869
120.6780.00.3220.0
130.0060.9420.0020.05
140.2960.2390.1240.341
150.0960.4580.080.367
160.3220.1540.1890.336
PWM
ACGT
01-0.048-0.124-0.070.209
02-0.177-0.7080.78-0.716
03-1.740.237-1.3720.834
040.4260.68-1.295-1.511
051.198-1.475-2.21-1.056
061.274-2.806-3.123-1.142
07-4.954-4.954-4.9541.381
081.165-4.954-0.249-4.954
09-4.954-4.954-4.9541.381
10-4.954-4.954-4.9541.381
11-4.954-4.954-0.6371.24
120.994-4.9540.25-4.954
13-3.4511.321-4.182-1.589
140.167-0.045-0.6930.309
15-0.9490.601-1.1230.381
160.252-0.483-0.2790.293
Standard thresholds
P-value Threshold
0.001 1.72306
0.0005 3.18311
0.0001 6.19371