MotifFOXA1.H12CORE.0.P.B
Gene (human)FOXA1
(GeneCards)
Gene synonyms (human)HNF3A, TCF3A
Gene (mouse)Foxa1
Gene synonyms (mouse)Hnf3a, Tcf-3a, Tcf3a
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
B
Motif length11
ConsensusTGTTTACWbdv
GC content31.27%
Information content (bits; total / per base)10.072 / 0.916
Data sourcesChIP-Seq
Aligned words1004

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 203 (408) 0.93 0.969 0.854 0.932 0.935 0.964 3.651 4.327 276.431 728.086
Mouse 32 (69) 0.93 0.946 0.857 0.887 0.936 0.949 3.754 4.028 474.081 723.137

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 4 experiments median 0.933 0.908 0.811 0.799 0.677 0.691
best 0.986 0.983 0.954 0.934 0.859 0.847
Methyl HT-SELEX, 2 experiments median 0.879 0.843 0.768 0.742 0.662 0.66
best 0.886 0.851 0.791 0.759 0.686 0.677
Non-Methyl HT-SELEX, 2 experiments median 0.982 0.974 0.892 0.887 0.763 0.776
best 0.986 0.983 0.954 0.934 0.859 0.847

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 8.24 158.291 0.333 0.321

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.917 0.259 0.893 0.668
batch 2 0.792 0.481 0.67 0.496
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classFork head/winged helix factors {3.3} (TFClass)
TF familyFOX {3.3.1} (TFClass)
TF subfamilyFOXA {3.3.1.1} (TFClass)
TFClass IDTFClass: 3.3.1.1.1
HGNCHGNC:5021
MGIMGI:1347472
EntrezGene (human)GeneID:3169
(SSTAR profile)
EntrezGene (mouse)GeneID:15375
(SSTAR profile)
UniProt ID (human)FOXA1_HUMAN
UniProt ID (mouse)FOXA1_MOUSE
UniProt AC (human)P55317
(TFClass)
UniProt AC (mouse)P35582
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 203 human, 32 mouse
HT-SELEX 2
Methyl-HT-SELEX 2
PCM
ACGT
0132.017.023.0932.0
02272.010.0716.06.0
039.020.025.0950.0
0411.04.099.0890.0
056.03.0178.0817.0
06773.010.0193.028.0
0730.0805.013.0156.0
08414.0150.023.0417.0
09108.0273.0166.0457.0
10477.065.081.0381.0
11250.0180.0400.0174.0
PFM
ACGT
010.0320.0170.0230.928
020.2710.010.7130.006
030.0090.020.0250.946
040.0110.0040.0990.886
050.0060.0030.1770.814
060.770.010.1920.028
070.030.8020.0130.155
080.4120.1490.0230.415
090.1080.2720.1650.455
100.4750.0650.0810.379
110.2490.1790.3980.173
PWM
ACGT
01-2.014-2.602-2.3241.307
020.08-3.071.044-3.487
03-3.159-2.454-2.2471.326
04-2.989-3.787-0.921.261
05-3.487-3.979-0.3411.175
061.12-3.07-0.261-2.14
07-2.0751.161-2.843-0.471
080.498-0.51-2.3240.505
09-0.8340.083-0.410.596
100.639-1.332-1.1170.415
11-0.004-0.330.463-0.363
Standard thresholds
P-value Threshold
0.001 4.71108
0.0005 5.581055
0.0001 7.38965