FLI1.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	FLI1.H12INVIVO.0.PSM.A
Gene (human)	FLI1 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Fli1
Gene synonyms (mouse)	Fli-1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	15
Consensus	vRCMGGAAGYvvvbb
GC content	59.21%
Information content (bits; total / per base)	13.321 / 0.888
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	1001

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	35 (207)	0.91	0.958	0.812	0.894	0.868	0.946	3.145	4.134	150.432	330.921
Mouse	25 (133)	0.902	0.971	0.825	0.948	0.898	0.969	3.721	4.839	168.569	429.046

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 9 experiments	median	0.961	0.942	0.802	0.805	0.649	0.682
Overall, 9 experiments	best	0.997	0.995	0.993	0.99	0.924	0.927
Methyl HT-SELEX, 2 experiments	median	0.674	0.661	0.577	0.585	0.537	0.549
Methyl HT-SELEX, 2 experiments	best	0.688	0.676	0.584	0.593	0.541	0.554
Non-Methyl HT-SELEX, 7 experiments	median	0.984	0.974	0.913	0.904	0.742	0.764
Non-Methyl HT-SELEX, 7 experiments	best	0.997	0.995	0.993	0.99	0.924	0.927

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	3.793	14.008	0.29	0.161

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.85	0.625	0.835	0.548
batch 2	0.693	0.613	0.713	0.572

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.6
HGNC	HGNC:3749
MGI	MGI:95554
EntrezGene (human)	GeneID:2313 (SSTAR profile)
EntrezGene (mouse)	GeneID:14247 (SSTAR profile)
UniProt ID (human)	FLI1_HUMAN
UniProt ID (mouse)	FLI1_MOUSE
UniProt AC (human)	Q01543 (TFClass)
UniProt AC (mouse)	P26323 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	35 human, 25 mouse
HT-SELEX	7
Methyl-HT-SELEX	2

PCM	FLI1.H12INVIVO.0.PSM.A.pcm
PWM	FLI1.H12INVIVO.0.PSM.A.pwm
PFM	FLI1.H12INVIVO.0.PSM.A.pfm
Alignment	FLI1.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	FLI1.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	FLI1.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	FLI1.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	FLI1.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	FLI1.H12INVIVO.0.PSM.A_homer_format_0.001.txt FLI1.H12INVIVO.0.PSM.A_homer_format_0.0005.txt FLI1.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	268.0	292.0	359.0	82.0
02	560.0	65.0	295.0	81.0
03	48.0	835.0	115.0	3.0
04	529.0	471.0	1.0	0.0
05	0.0	0.0	1001.0	0.0
06	1.0	1.0	999.0	0.0
07	1000.0	0.0	0.0	1.0
08	955.0	0.0	0.0	46.0
09	299.0	7.0	695.0	0.0
10	28.0	387.0	41.0	545.0
11	226.0	130.0	548.0	97.0
12	227.0	224.0	504.0	46.0
13	134.0	423.0	316.0	128.0
14	153.0	163.0	329.0	356.0
15	144.0	223.0	467.0	167.0

PFM

	A	C	G	T
01	0.268	0.292	0.359	0.082
02	0.559	0.065	0.295	0.081
03	0.048	0.834	0.115	0.003
04	0.528	0.471	0.001	0.0
05	0.0	0.0	1.0	0.0
06	0.001	0.001	0.998	0.0
07	0.999	0.0	0.0	0.001
08	0.954	0.0	0.0	0.046
09	0.299	0.007	0.694	0.0
10	0.028	0.387	0.041	0.544
11	0.226	0.13	0.547	0.097
12	0.227	0.224	0.503	0.046
13	0.134	0.423	0.316	0.128
14	0.153	0.163	0.329	0.356
15	0.144	0.223	0.467	0.167

PWM

	A	C	G	T
01	0.068	0.153	0.359	-1.102
02	0.802	-1.329	0.163	-1.114
03	-1.623	1.2	-0.769	-3.976
04	0.745	0.629	-4.526	-4.983
05	-4.983	-4.983	1.381	-4.983
06	-4.526	-4.526	1.379	-4.983
07	1.38	-4.983	-4.983	-4.526
08	1.334	-4.983	-4.983	-1.664
09	0.177	-3.363	1.017	-4.983
10	-2.137	0.434	-1.775	0.775
11	-0.101	-0.649	0.78	-0.937
12	-0.097	-0.11	0.697	-1.664
13	-0.619	0.522	0.232	-0.664
14	-0.488	-0.425	0.272	0.35
15	-0.548	-0.114	0.621	-0.401

Standard thresholds

P-value	Threshold
0.001	3.11426
0.0005	4.47191
0.0001	7.22601