FLI1.H12INVITRO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	FLI1.H12INVITRO.0.PSM.A
Gene (human)	FLI1 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Fli1
Gene synonyms (mouse)	Fli-1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	12
Consensus	nRCCGGAARYvv
GC content	56.82%
Information content (bits; total / per base)	13.253 / 1.104
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	9965

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	35 (207)	0.886	0.952	0.788	0.897	0.796	0.912	2.441	3.637	123.319	335.409
Mouse	25 (133)	0.897	0.968	0.815	0.948	0.848	0.952	3.1	4.365	159.292	411.886

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 9 experiments	median	0.985	0.979	0.805	0.823	0.638	0.686
Overall, 9 experiments	best	0.999	0.999	0.998	0.997	0.961	0.962
Methyl HT-SELEX, 2 experiments	median	0.665	0.667	0.561	0.581	0.52	0.543
Methyl HT-SELEX, 2 experiments	best	0.683	0.696	0.562	0.592	0.522	0.547
Non-Methyl HT-SELEX, 7 experiments	median	0.994	0.991	0.951	0.945	0.774	0.8
Non-Methyl HT-SELEX, 7 experiments	best	0.999	0.999	0.998	0.997	0.961	0.962

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	3.69	13.221	0.246	0.148

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.879	0.745	0.864	0.583
batch 2	0.808	0.693	0.762	0.633

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.6
HGNC	HGNC:3749
MGI	MGI:95554
EntrezGene (human)	GeneID:2313 (SSTAR profile)
EntrezGene (mouse)	GeneID:14247 (SSTAR profile)
UniProt ID (human)	FLI1_HUMAN
UniProt ID (mouse)	FLI1_MOUSE
UniProt AC (human)	Q01543 (TFClass)
UniProt AC (mouse)	P26323 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	35 human, 25 mouse
HT-SELEX	7
Methyl-HT-SELEX	2

PCM	FLI1.H12INVITRO.0.PSM.A.pcm
PWM	FLI1.H12INVITRO.0.PSM.A.pwm
PFM	FLI1.H12INVITRO.0.PSM.A.pfm
Alignment	FLI1.H12INVITRO.0.PSM.A.words.tsv
Threshold to P-value map	FLI1.H12INVITRO.0.PSM.A.thr
Motif in other formats
JASPAR format	FLI1.H12INVITRO.0.PSM.A_jaspar_format.txt
MEME format	FLI1.H12INVITRO.0.PSM.A_meme_format.meme
Transfac format	FLI1.H12INVITRO.0.PSM.A_transfac_format.txt
Homer format	FLI1.H12INVITRO.0.PSM.A_homer_format_0.001.txt FLI1.H12INVITRO.0.PSM.A_homer_format_0.0005.txt FLI1.H12INVITRO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2546.75	2287.75	3163.75	1966.75
02	6622.0	286.0	1797.0	1260.0
03	309.0	9078.0	533.0	45.0
04	276.0	9684.0	2.0	3.0
05	0.0	0.0	9965.0	0.0
06	0.0	0.0	9965.0	0.0
07	9963.0	0.0	0.0	2.0
08	8405.0	7.0	3.0	1550.0
09	4472.0	105.0	5312.0	76.0
10	184.0	2378.0	325.0	7078.0
11	2047.5	2853.5	3796.5	1267.5
12	2182.0	3822.0	2583.0	1378.0

PFM

	A	C	G	T
01	0.256	0.23	0.317	0.197
02	0.665	0.029	0.18	0.126
03	0.031	0.911	0.053	0.005
04	0.028	0.972	0.0	0.0
05	0.0	0.0	1.0	0.0
06	0.0	0.0	1.0	0.0
07	1.0	0.0	0.0	0.0
08	0.843	0.001	0.0	0.156
09	0.449	0.011	0.533	0.008
10	0.018	0.239	0.033	0.71
11	0.205	0.286	0.381	0.127
12	0.219	0.384	0.259	0.138

PWM

	A	C	G	T
01	0.022	-0.085	0.239	-0.236
02	0.977	-2.157	-0.326	-0.681
03	-2.081	1.292	-1.539	-3.965
04	-2.193	1.357	-6.362	-6.153
05	-6.988	-6.988	1.386	-6.988
06	-6.988	-6.988	1.386	-6.988
07	1.385	-6.988	-6.988	-6.362
08	1.215	-5.591	-6.153	-0.474
09	0.585	-3.146	0.757	-3.461
10	-2.594	-0.046	-2.031	1.044
11	-0.196	0.136	0.421	-0.675
12	-0.132	0.428	0.036	-0.591

Standard thresholds

P-value	Threshold
0.001	2.47651
0.0005	4.15419
0.0001	7.179915