FLI1.H12CORE.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	FLI1.H12CORE.0.PSM.A
Gene (human)	FLI1 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Fli1
Gene synonyms (mouse)	Fli-1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	12
Consensus	dCCGGAAGYvvv
GC content	58.24%
Information content (bits; total / per base)	12.652 / 1.054
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	430

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	35 (207)	0.902	0.953	0.808	0.899	0.838	0.94	2.976	4.16	136.208	334.194
Mouse	25 (133)	0.902	0.974	0.825	0.955	0.892	0.965	3.593	4.8	166.959	428.921

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 9 experiments	median	0.974	0.965	0.803	0.815	0.647	0.685
Overall, 9 experiments	best	0.999	0.998	0.996	0.995	0.951	0.951
Methyl HT-SELEX, 2 experiments	median	0.675	0.671	0.574	0.587	0.532	0.549
Methyl HT-SELEX, 2 experiments	best	0.687	0.688	0.577	0.595	0.534	0.553
Non-Methyl HT-SELEX, 7 experiments	median	0.991	0.986	0.935	0.928	0.765	0.787
Non-Methyl HT-SELEX, 7 experiments	best	0.999	0.998	0.996	0.995	0.951	0.951

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	4.356	16.04	0.299	0.162

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.879	0.729	0.877	0.577
batch 2	0.762	0.652	0.745	0.608

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.6
HGNC	HGNC:3749
MGI	MGI:95554
EntrezGene (human)	GeneID:2313 (SSTAR profile)
EntrezGene (mouse)	GeneID:14247 (SSTAR profile)
UniProt ID (human)	FLI1_HUMAN
UniProt ID (mouse)	FLI1_MOUSE
UniProt AC (human)	Q01543 (TFClass)
UniProt AC (mouse)	P26323 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	35 human, 25 mouse
HT-SELEX	7
Methyl-HT-SELEX	2

PCM	FLI1.H12CORE.0.PSM.A.pcm
PWM	FLI1.H12CORE.0.PSM.A.pwm
PFM	FLI1.H12CORE.0.PSM.A.pfm
Alignment	FLI1.H12CORE.0.PSM.A.words.tsv
Threshold to P-value map	FLI1.H12CORE.0.PSM.A.thr
Motif in other formats
JASPAR format	FLI1.H12CORE.0.PSM.A_jaspar_format.txt
MEME format	FLI1.H12CORE.0.PSM.A_meme_format.meme
Transfac format	FLI1.H12CORE.0.PSM.A_transfac_format.txt
Homer format	FLI1.H12CORE.0.PSM.A_homer_format_0.001.txt FLI1.H12CORE.0.PSM.A_homer_format_0.0005.txt FLI1.H12CORE.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	238.0	37.0	111.0	44.0
02	18.0	362.0	47.0	3.0
03	138.0	288.0	2.0	2.0
04	0.0	0.0	427.0	3.0
05	0.0	0.0	428.0	2.0
06	427.0	0.0	2.0	1.0
07	411.0	1.0	2.0	16.0
08	120.0	3.0	307.0	0.0
09	14.0	88.0	19.0	309.0
10	69.0	63.0	250.0	48.0
11	95.0	127.0	168.0	40.0
12	94.0	168.0	105.0	63.0

PFM

	A	C	G	T
01	0.553	0.086	0.258	0.102
02	0.042	0.842	0.109	0.007
03	0.321	0.67	0.005	0.005
04	0.0	0.0	0.993	0.007
05	0.0	0.0	0.995	0.005
06	0.993	0.0	0.005	0.002
07	0.956	0.002	0.005	0.037
08	0.279	0.007	0.714	0.0
09	0.033	0.205	0.044	0.719
10	0.16	0.147	0.581	0.112
11	0.221	0.295	0.391	0.093
12	0.219	0.391	0.244	0.147

PWM

	A	C	G	T
01	0.787	-1.04	0.032	-0.873
02	-1.72	1.204	-0.81	-3.184
03	0.247	0.977	-3.434	-3.434
04	-4.275	-4.275	1.369	-3.184
05	-4.275	-4.275	1.371	-3.434
06	1.369	-4.275	-3.434	-3.769
07	1.331	-3.769	-3.434	-1.828
08	0.109	-3.184	1.04	-4.275
09	-1.95	-0.197	-1.67	1.047
10	-0.436	-0.525	0.836	-0.789
11	-0.122	0.165	0.441	-0.965
12	-0.132	0.441	-0.023	-0.525

Standard thresholds

P-value	Threshold
0.001	3.842515
0.0005	4.95703
0.0001	7.31258