FIGLA.H12RSNP.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	FIGLA.H12RSNP.0.SM.B
Gene (human)	FIGLA (GeneCards)
Gene synonyms (human)	BHLHC8
Gene (mouse)	Figla
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	11
Consensus	nhhCACCTGbn
GC content	54.28%
Information content (bits; total / per base)	12.421 / 1.129
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	1700

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.995	0.99	0.993	0.988	0.991	0.984
Overall, 3 experiments	best	0.996	0.992	0.995	0.991	0.993	0.988
Methyl HT-SELEX, 1 experiments	median	0.996	0.992	0.995	0.991	0.993	0.988
Methyl HT-SELEX, 1 experiments	best	0.996	0.992	0.995	0.991	0.993	0.988
Non-Methyl HT-SELEX, 2 experiments	median	0.848	0.846	0.788	0.795	0.762	0.77
Non-Methyl HT-SELEX, 2 experiments	best	0.995	0.99	0.993	0.988	0.991	0.984

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.983	0.908	0.966	0.563
batch 2	0.986	0.846	0.958	0.583

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	Tal-related {1.2.3} (TFClass)
TF subfamily	TWIST {1.2.3.2} (TFClass)
TFClass ID	TFClass: 1.2.3.2.8
HGNC	HGNC:24669
MGI	MGI:1349421
EntrezGene (human)	GeneID:344018 (SSTAR profile)
EntrezGene (mouse)	GeneID:26910 (SSTAR profile)
UniProt ID (human)	FIGLA_HUMAN
UniProt ID (mouse)	FIGLA_MOUSE
UniProt AC (human)	Q6QHK4 (TFClass)
UniProt AC (mouse)	O55208 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	FIGLA.H12RSNP.0.SM.B.pcm
PWM	FIGLA.H12RSNP.0.SM.B.pwm
PFM	FIGLA.H12RSNP.0.SM.B.pfm
Alignment	FIGLA.H12RSNP.0.SM.B.words.tsv
Threshold to P-value map	FIGLA.H12RSNP.0.SM.B.thr
Motif in other formats
JASPAR format	FIGLA.H12RSNP.0.SM.B_jaspar_format.txt
MEME format	FIGLA.H12RSNP.0.SM.B_meme_format.meme
Transfac format	FIGLA.H12RSNP.0.SM.B_transfac_format.txt
Homer format	FIGLA.H12RSNP.0.SM.B_homer_format_0.001.txt FIGLA.H12RSNP.0.SM.B_homer_format_0.0005.txt FIGLA.H12RSNP.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	528.25	384.25	339.25	448.25
02	861.0	278.0	205.0	356.0
03	752.75	661.75	122.75	162.75
04	0.0	1700.0	0.0	0.0
05	1700.0	0.0	0.0	0.0
06	0.0	1479.0	221.0	0.0
07	0.0	1700.0	0.0	0.0
08	0.0	0.0	0.0	1700.0
09	0.0	0.0	1700.0	0.0
10	153.5	177.5	561.5	807.5
11	465.25	302.25	317.25	615.25

PFM

	A	C	G	T
01	0.311	0.226	0.2	0.264
02	0.506	0.164	0.121	0.209
03	0.443	0.389	0.072	0.096
04	0.0	1.0	0.0	0.0
05	1.0	0.0	0.0	0.0
06	0.0	0.87	0.13	0.0
07	0.0	1.0	0.0	0.0
08	0.0	0.0	0.0	1.0
09	0.0	0.0	1.0	0.0
10	0.09	0.104	0.33	0.475
11	0.274	0.178	0.187	0.362

PWM

	A	C	G	T
01	0.217	-0.1	-0.224	0.053
02	0.704	-0.422	-0.724	-0.176
03	0.57	0.441	-1.231	-0.953
04	-5.436	1.383	-5.436	-5.436
05	1.383	-5.436	-5.436	-5.436
06	-5.436	1.244	-0.65	-5.436
07	-5.436	1.383	-5.436	-5.436
08	-5.436	-5.436	-5.436	1.383
09	-5.436	-5.436	1.383	-5.436
10	-1.011	-0.867	0.277	0.64
11	0.09	-0.339	-0.291	0.369

Standard thresholds

P-value	Threshold
0.001	2.100105
0.0005	3.49984
0.0001	7.83296