EVX2.H12RSNP.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	EVX2.H12RSNP.0.SM.B
Gene (human)	EVX2 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Evx2
Gene synonyms (mouse)	Evx-2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	13
Consensus	nbvYTAATYAbbn
GC content	36.96%
Information content (bits; total / per base)	11.554 / 0.889
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	8376

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.99	0.982	0.981	0.97	0.958	0.943
Overall, 4 experiments	best	0.991	0.986	0.983	0.974	0.964	0.95
Methyl HT-SELEX, 1 experiments	median	0.989	0.981	0.98	0.968	0.961	0.945
Methyl HT-SELEX, 1 experiments	best	0.989	0.981	0.98	0.968	0.961	0.945
Non-Methyl HT-SELEX, 3 experiments	median	0.99	0.984	0.982	0.971	0.956	0.941
Non-Methyl HT-SELEX, 3 experiments	best	0.991	0.986	0.983	0.974	0.964	0.95

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.721	0.466	0.696	0.483

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HOX-related {3.1.1} (TFClass)
TF subfamily	EVX {3.1.1.10} (TFClass)
TFClass ID	TFClass: 3.1.1.10.2
HGNC	HGNC:3507
MGI	MGI:95462
EntrezGene (human)	GeneID:344191 (SSTAR profile)
EntrezGene (mouse)	GeneID:14029 (SSTAR profile)
UniProt ID (human)	EVX2_HUMAN
UniProt ID (mouse)	EVX2_MOUSE
UniProt AC (human)	Q03828 (TFClass)
UniProt AC (mouse)	P49749 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	EVX2.H12RSNP.0.SM.B.pcm
PWM	EVX2.H12RSNP.0.SM.B.pwm
PFM	EVX2.H12RSNP.0.SM.B.pfm
Alignment	EVX2.H12RSNP.0.SM.B.words.tsv
Threshold to P-value map	EVX2.H12RSNP.0.SM.B.thr
Motif in other formats
JASPAR format	EVX2.H12RSNP.0.SM.B_jaspar_format.txt
MEME format	EVX2.H12RSNP.0.SM.B_meme_format.meme
Transfac format	EVX2.H12RSNP.0.SM.B_transfac_format.txt
Homer format	EVX2.H12RSNP.0.SM.B_homer_format_0.001.txt EVX2.H12RSNP.0.SM.B_homer_format_0.0005.txt EVX2.H12RSNP.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1671.0	2114.0	2500.0	2091.0
02	1220.5	3358.5	1908.5	1888.5
03	3307.0	1675.0	3003.0	391.0
04	463.0	5628.0	395.0	1890.0
05	0.0	0.0	0.0	8376.0
06	8376.0	0.0	0.0	0.0
07	8376.0	0.0	0.0	0.0
08	0.0	1.0	0.0	8375.0
09	8.0	1648.0	1476.0	5244.0
10	7502.0	37.0	723.0	114.0
11	439.0	3885.0	2426.0	1626.0
12	1081.5	3271.5	2003.5	2019.5
13	2148.25	2179.25	2009.25	2039.25

PFM

	A	C	G	T
01	0.199	0.252	0.298	0.25
02	0.146	0.401	0.228	0.225
03	0.395	0.2	0.359	0.047
04	0.055	0.672	0.047	0.226
05	0.0	0.0	0.0	1.0
06	1.0	0.0	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.0	0.0	0.0	1.0
09	0.001	0.197	0.176	0.626
10	0.896	0.004	0.086	0.014
11	0.052	0.464	0.29	0.194
12	0.129	0.391	0.239	0.241
13	0.256	0.26	0.24	0.243

PWM

	A	C	G	T
01	-0.225	0.009	0.177	-0.001
02	-0.539	0.472	-0.093	-0.103
03	0.457	-0.223	0.36	-1.673
04	-1.505	0.988	-1.663	-0.102
05	-6.833	-6.833	-6.833	1.385
06	1.385	-6.833	-6.833	-6.833
07	1.385	-6.833	-6.833	-6.833
08	-6.833	-6.467	-6.833	1.385
09	-5.32	-0.239	-0.349	0.917
10	1.275	-3.978	-1.061	-2.892
11	-1.558	0.618	0.147	-0.253
12	-0.66	0.446	-0.044	-0.036
13	0.026	0.04	-0.041	-0.026

Standard thresholds

P-value	Threshold
0.001	3.84551
0.0005	5.45256
0.0001	7.72438