EVX2.H12CORE.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	EVX2.H12CORE.1.S.B
Gene (human)	EVX2 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Evx2
Gene synonyms (mouse)	Evx-2
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	17
Consensus	hWdWdnRYTAATTASbv
GC content	30.42%
Information content (bits; total / per base)	15.696 / 0.923
Data sources	HT-SELEX
Aligned words	355

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.987	0.979	0.977	0.965	0.95	0.933
Overall, 4 experiments	best	0.989	0.983	0.98	0.969	0.96	0.944
Methyl HT-SELEX, 1 experiments	median	0.989	0.983	0.98	0.969	0.96	0.944
Methyl HT-SELEX, 1 experiments	best	0.989	0.983	0.98	0.969	0.96	0.944
Non-Methyl HT-SELEX, 3 experiments	median	0.987	0.977	0.977	0.965	0.942	0.926
Non-Methyl HT-SELEX, 3 experiments	best	0.988	0.98	0.978	0.965	0.958	0.94

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.656	0.334	0.652	0.443

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HOX-related {3.1.1} (TFClass)
TF subfamily	EVX {3.1.1.10} (TFClass)
TFClass ID	TFClass: 3.1.1.10.2
HGNC	HGNC:3507
MGI	MGI:95462
EntrezGene (human)	GeneID:344191 (SSTAR profile)
EntrezGene (mouse)	GeneID:14029 (SSTAR profile)
UniProt ID (human)	EVX2_HUMAN
UniProt ID (mouse)	EVX2_MOUSE
UniProt AC (human)	Q03828 (TFClass)
UniProt AC (mouse)	P49749 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	EVX2.H12CORE.1.S.B.pcm
PWM	EVX2.H12CORE.1.S.B.pwm
PFM	EVX2.H12CORE.1.S.B.pfm
Alignment	EVX2.H12CORE.1.S.B.words.tsv
Threshold to P-value map	EVX2.H12CORE.1.S.B.thr
Motif in other formats
JASPAR format	EVX2.H12CORE.1.S.B_jaspar_format.txt
MEME format	EVX2.H12CORE.1.S.B_meme_format.meme
Transfac format	EVX2.H12CORE.1.S.B_transfac_format.txt
Homer format	EVX2.H12CORE.1.S.B_homer_format_0.001.txt EVX2.H12CORE.1.S.B_homer_format_0.0005.txt EVX2.H12CORE.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	138.0	50.0	38.0	129.0
02	103.25	13.25	11.25	227.25
03	191.0	18.0	48.0	98.0
04	208.0	10.0	39.0	98.0
05	45.0	35.0	91.0	184.0
06	68.0	132.0	81.0	74.0
07	196.0	51.0	104.0	4.0
08	4.0	255.0	47.0	49.0
09	0.0	0.0	0.0	355.0
10	341.0	7.0	7.0	0.0
11	355.0	0.0	0.0	0.0
12	0.0	0.0	0.0	355.0
13	0.0	10.0	17.0	328.0
14	353.0	0.0	2.0	0.0
15	39.0	66.0	231.0	19.0
16	12.75	125.75	110.75	105.75
17	63.0	91.0	145.0	56.0

PFM

	A	C	G	T
01	0.389	0.141	0.107	0.363
02	0.291	0.037	0.032	0.64
03	0.538	0.051	0.135	0.276
04	0.586	0.028	0.11	0.276
05	0.127	0.099	0.256	0.518
06	0.192	0.372	0.228	0.208
07	0.552	0.144	0.293	0.011
08	0.011	0.718	0.132	0.138
09	0.0	0.0	0.0	1.0
10	0.961	0.02	0.02	0.0
11	1.0	0.0	0.0	0.0
12	0.0	0.0	0.0	1.0
13	0.0	0.028	0.048	0.924
14	0.994	0.0	0.006	0.0
15	0.11	0.186	0.651	0.054
16	0.036	0.354	0.312	0.298
17	0.177	0.256	0.408	0.158

PWM

	A	C	G	T
01	0.436	-0.561	-0.827	0.369
02	0.149	-1.813	-1.959	0.93
03	0.758	-1.533	-0.601	0.098
04	0.842	-2.063	-0.802	0.098
05	-0.663	-0.906	0.025	0.721
06	-0.261	0.392	-0.09	-0.179
07	0.783	-0.542	0.156	-2.803
08	-2.803	1.045	-0.621	-0.581
09	-4.118	-4.118	-4.118	1.374
10	1.334	-2.366	-2.366	-4.118
11	1.374	-4.118	-4.118	-4.118
12	-4.118	-4.118	-4.118	1.374
13	-4.118	-2.063	-1.586	1.295
14	1.368	-4.118	-3.259	-4.118
15	-0.802	-0.291	0.947	-1.483
16	-1.848	0.344	0.218	0.173
17	-0.336	0.025	0.485	-0.451

Standard thresholds

P-value	Threshold
0.001	2.51751
0.0005	3.80321
0.0001	6.46786