EVX1.H12RSNP.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	EVX1.H12RSNP.0.SM.B
Gene (human)	EVX1 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Evx1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	nnvhTAATbRnn
GC content	32.71%
Information content (bits; total / per base)	9.547 / 0.796
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9629

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.97	0.952	0.941	0.916	0.867	0.848
Overall, 4 experiments	best	0.977	0.963	0.96	0.94	0.931	0.905
Methyl HT-SELEX, 1 experiments	median	0.977	0.963	0.96	0.94	0.931	0.905
Methyl HT-SELEX, 1 experiments	best	0.977	0.963	0.96	0.94	0.931	0.905
Non-Methyl HT-SELEX, 3 experiments	median	0.964	0.944	0.925	0.897	0.808	0.798
Non-Methyl HT-SELEX, 3 experiments	best	0.976	0.96	0.957	0.935	0.927	0.899

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.773	0.597	0.769	0.594

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HOX-related {3.1.1} (TFClass)
TF subfamily	EVX {3.1.1.10} (TFClass)
TFClass ID	TFClass: 3.1.1.10.1
HGNC	HGNC:3506
MGI	MGI:95461
EntrezGene (human)	GeneID:2128 (SSTAR profile)
EntrezGene (mouse)	GeneID:14028 (SSTAR profile)
UniProt ID (human)	EVX1_HUMAN
UniProt ID (mouse)	EVX1_MOUSE
UniProt AC (human)	P49640 (TFClass)
UniProt AC (mouse)	P23683 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	EVX1.H12RSNP.0.SM.B.pcm
PWM	EVX1.H12RSNP.0.SM.B.pwm
PFM	EVX1.H12RSNP.0.SM.B.pfm
Alignment	EVX1.H12RSNP.0.SM.B.words.tsv
Threshold to P-value map	EVX1.H12RSNP.0.SM.B.thr
Motif in other formats
JASPAR format	EVX1.H12RSNP.0.SM.B_jaspar_format.txt
MEME format	EVX1.H12RSNP.0.SM.B_meme_format.meme
Transfac format	EVX1.H12RSNP.0.SM.B_transfac_format.txt
Homer format	EVX1.H12RSNP.0.SM.B_homer_format_0.001.txt EVX1.H12RSNP.0.SM.B_homer_format_0.0005.txt EVX1.H12RSNP.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2404.0	2544.0	2359.0	2322.0
02	1862.75	3151.75	1476.75	3137.75
03	3460.0	2270.0	3184.0	715.0
04	2752.0	3918.0	1186.0	1773.0
05	0.0	0.0	0.0	9629.0
06	9617.0	1.0	11.0	0.0
07	9629.0	0.0	0.0	0.0
08	0.0	4.0	1.0	9624.0
09	94.0	3301.0	2297.0	3937.0
10	6862.0	357.0	1830.0	580.0
11	1950.5	3148.5	2115.5	2414.5
12	2341.25	2479.25	2162.25	2646.25

PFM

	A	C	G	T
01	0.25	0.264	0.245	0.241
02	0.193	0.327	0.153	0.326
03	0.359	0.236	0.331	0.074
04	0.286	0.407	0.123	0.184
05	0.0	0.0	0.0	1.0
06	0.999	0.0	0.001	0.0
07	1.0	0.0	0.0	0.0
08	0.0	0.0	0.0	0.999
09	0.01	0.343	0.239	0.409
10	0.713	0.037	0.19	0.06
11	0.203	0.327	0.22	0.251
12	0.243	0.257	0.225	0.275

PWM

	A	C	G	T
01	-0.001	0.055	-0.02	-0.036
02	-0.256	0.269	-0.488	0.265
03	0.362	-0.059	0.279	-1.212
04	0.134	0.487	-0.707	-0.305
05	-6.957	-6.957	-6.957	1.386
06	1.384	-6.595	-5.2	-6.957
07	1.386	-6.957	-6.957	-6.957
08	-6.957	-5.948	-6.595	1.385
09	-3.22	0.315	-0.047	0.492
10	1.047	-1.903	-0.274	-1.42
11	-0.21	0.268	-0.129	0.003
12	-0.028	0.029	-0.107	0.095

Standard thresholds

P-value	Threshold
0.001	5.41651
0.0005	6.351925
0.0001	7.499795