EVX1.H12CORE.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	EVX1.H12CORE.0.SM.B
Gene (human)	EVX1 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Evx1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	nhvhTAATYAbn
GC content	34.11%
Information content (bits; total / per base)	10.609 / 0.884
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	6355

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.971	0.954	0.942	0.918	0.868	0.85
Overall, 4 experiments	best	0.977	0.963	0.96	0.938	0.931	0.904
Methyl HT-SELEX, 1 experiments	median	0.975	0.96	0.96	0.938	0.931	0.904
Methyl HT-SELEX, 1 experiments	best	0.975	0.96	0.96	0.938	0.931	0.904
Non-Methyl HT-SELEX, 3 experiments	median	0.966	0.948	0.926	0.9	0.809	0.8
Non-Methyl HT-SELEX, 3 experiments	best	0.977	0.963	0.958	0.937	0.927	0.899

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.752	0.565	0.749	0.553

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HOX-related {3.1.1} (TFClass)
TF subfamily	EVX {3.1.1.10} (TFClass)
TFClass ID	TFClass: 3.1.1.10.1
HGNC	HGNC:3506
MGI	MGI:95461
EntrezGene (human)	GeneID:2128 (SSTAR profile)
EntrezGene (mouse)	GeneID:14028 (SSTAR profile)
UniProt ID (human)	EVX1_HUMAN
UniProt ID (mouse)	EVX1_MOUSE
UniProt AC (human)	P49640 (TFClass)
UniProt AC (mouse)	P23683 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	EVX1.H12CORE.0.SM.B.pcm
PWM	EVX1.H12CORE.0.SM.B.pwm
PFM	EVX1.H12CORE.0.SM.B.pfm
Alignment	EVX1.H12CORE.0.SM.B.words.tsv
Threshold to P-value map	EVX1.H12CORE.0.SM.B.thr
Motif in other formats
JASPAR format	EVX1.H12CORE.0.SM.B_jaspar_format.txt
MEME format	EVX1.H12CORE.0.SM.B_meme_format.meme
Transfac format	EVX1.H12CORE.0.SM.B_transfac_format.txt
Homer format	EVX1.H12CORE.0.SM.B_homer_format_0.001.txt EVX1.H12CORE.0.SM.B_homer_format_0.0005.txt EVX1.H12CORE.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1525.75	1781.75	1577.75	1469.75
02	1050.5	2532.5	787.5	1984.5
03	2258.0	1470.0	2385.0	242.0
04	1737.0	3364.0	468.0	786.0
05	0.0	0.0	0.0	6355.0
06	6355.0	0.0	0.0	0.0
07	6355.0	0.0	0.0	0.0
08	0.0	0.0	0.0	6355.0
09	7.0	2296.0	1284.0	2768.0
10	5380.0	55.0	808.0	112.0
11	958.5	2636.5	1379.5	1380.5
12	1507.75	1785.75	1401.75	1659.75

PFM

	A	C	G	T
01	0.24	0.28	0.248	0.231
02	0.165	0.399	0.124	0.312
03	0.355	0.231	0.375	0.038
04	0.273	0.529	0.074	0.124
05	0.0	0.0	0.0	1.0
06	1.0	0.0	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.0	0.0	0.0	1.0
09	0.001	0.361	0.202	0.436
10	0.847	0.009	0.127	0.018
11	0.151	0.415	0.217	0.217
12	0.237	0.281	0.221	0.261

PWM

	A	C	G	T
01	-0.04	0.114	-0.007	-0.078
02	-0.413	0.466	-0.7	0.222
03	0.351	-0.078	0.406	-1.874
04	0.089	0.749	-1.219	-0.702
05	-6.589	-6.589	-6.589	1.385
06	1.385	-6.589	-6.589	-6.589
07	1.385	-6.589	-6.589	-6.589
08	-6.589	-6.589	-6.589	1.385
09	-5.154	0.368	-0.213	0.555
10	1.219	-3.326	-0.675	-2.634
11	-0.504	0.506	-0.141	-0.14
12	-0.052	0.117	-0.125	0.044

Standard thresholds

P-value	Threshold
0.001	4.62424
0.0005	6.050515
0.0001	7.774845