ETV5.H12INVIVO.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ETV5.H12INVIVO.0.PS.A
Gene (human)	ETV5 (GeneCards)
Gene synonyms (human)	ERM
Gene (mouse)	Etv5
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	11
Consensus	ndCCGGAAGYd
GC content	58.42%
Information content (bits; total / per base)	12.988 / 1.181
Data sources	ChIP-Seq + HT-SELEX
Aligned words	8811

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (12)	0.694	0.925	0.537	0.855	0.605	0.875	1.37	2.952	9.527	361.495
Mouse	4 (20)	0.738	0.817	0.702	0.8	0.691	0.777	2.561	3.224	74.413	154.469

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.996	0.992	0.991	0.986	0.941	0.939
Overall, 4 experiments	best	0.997	0.996	0.994	0.991	0.989	0.983
Methyl HT-SELEX, 1 experiments	median	0.997	0.996	0.994	0.991	0.984	0.978
Methyl HT-SELEX, 1 experiments	best	0.997	0.996	0.994	0.991	0.984	0.978
Non-Methyl HT-SELEX, 3 experiments	median	0.995	0.991	0.988	0.982	0.898	0.9
Non-Methyl HT-SELEX, 3 experiments	best	0.996	0.993	0.994	0.989	0.989	0.983

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.958	0.908	0.966	0.732
batch 2	0.955	0.875	0.929	0.709

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ELK-like {3.5.2.2} (TFClass)
TFClass ID	TFClass: 3.5.2.2.6
HGNC	HGNC:3494
MGI	MGI:1096867
EntrezGene (human)	GeneID:2119 (SSTAR profile)
EntrezGene (mouse)	GeneID:104156 (SSTAR profile)
UniProt ID (human)	ETV5_HUMAN
UniProt ID (mouse)	ETV5_MOUSE
UniProt AC (human)	P41161 (TFClass)
UniProt AC (mouse)	Q9CXC9 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 4 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	ETV5.H12INVIVO.0.PS.A.pcm
PWM	ETV5.H12INVIVO.0.PS.A.pwm
PFM	ETV5.H12INVIVO.0.PS.A.pfm
Alignment	ETV5.H12INVIVO.0.PS.A.words.tsv
Threshold to P-value map	ETV5.H12INVIVO.0.PS.A.thr
Motif in other formats
JASPAR format	ETV5.H12INVIVO.0.PS.A_jaspar_format.txt
MEME format	ETV5.H12INVIVO.0.PS.A_meme_format.meme
Transfac format	ETV5.H12INVIVO.0.PS.A_transfac_format.txt
Homer format	ETV5.H12INVIVO.0.PS.A_homer_format_0.001.txt ETV5.H12INVIVO.0.PS.A_homer_format_0.0005.txt ETV5.H12INVIVO.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2044.5	1890.5	2387.5	2488.5
02	4188.75	333.75	1971.75	2316.75
03	387.0	7188.0	1178.0	58.0
04	112.0	8697.0	1.0	1.0
05	0.0	0.0	8811.0	0.0
06	0.0	0.0	8811.0	0.0
07	8811.0	0.0	0.0	0.0
08	7406.0	4.0	0.0	1401.0
09	561.0	197.0	8049.0	4.0
10	260.0	2236.0	601.0	5714.0
11	2774.0	1177.0	3087.0	1773.0

PFM

	A	C	G	T
01	0.232	0.215	0.271	0.282
02	0.475	0.038	0.224	0.263
03	0.044	0.816	0.134	0.007
04	0.013	0.987	0.0	0.0
05	0.0	0.0	1.0	0.0
06	0.0	0.0	1.0	0.0
07	1.0	0.0	0.0	0.0
08	0.841	0.0	0.0	0.159
09	0.064	0.022	0.914	0.0
10	0.03	0.254	0.068	0.649
11	0.315	0.134	0.35	0.201

PWM

	A	C	G	T
01	-0.074	-0.153	0.08	0.122
02	0.642	-1.881	-0.111	0.05
03	-1.734	1.182	-0.625	-3.6
04	-2.96	1.373	-6.513	-6.513
05	-6.878	-6.878	1.386	-6.878
06	-6.878	-6.878	1.386	-6.878
07	1.386	-6.878	-6.878	-6.878
08	1.212	-5.863	-6.878	-0.452
09	-1.365	-2.404	1.295	-5.863
10	-2.129	0.015	-1.296	0.953
11	0.23	-0.626	0.337	-0.217

Standard thresholds

P-value	Threshold
0.001	2.499135
0.0005	4.294225
0.0001	7.37971