ETV2.H12RSNP.0.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ETV2.H12RSNP.0.S.B
Gene (human)	ETV2 (GeneCards)
Gene synonyms (human)	ER71, ETSRP71
Gene (mouse)	Etv2
Gene synonyms (mouse)	Er71, Etsrp71
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	hWCCGGAARYdn
GC content	51.84%
Information content (bits; total / per base)	12.54 / 1.045
Data sources	HT-SELEX
Aligned words	810

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (6)	0.95	0.951	0.875	0.879	0.907	0.911	3.044	3.07	205.845	228.328
Mouse	2 (13)	0.95	0.964	0.867	0.908	0.927	0.93	3.283	3.34	248.854	277.658

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.989	0.982	0.986	0.976	0.964	0.954
Overall, 3 experiments	best	0.995	0.991	0.989	0.983	0.971	0.958
Methyl HT-SELEX, 1 experiments	median	0.989	0.982	0.986	0.976	0.971	0.958
Methyl HT-SELEX, 1 experiments	best	0.989	0.982	0.986	0.976	0.971	0.958
Non-Methyl HT-SELEX, 2 experiments	median	0.766	0.768	0.752	0.752	0.735	0.733
Non-Methyl HT-SELEX, 2 experiments	best	0.995	0.991	0.989	0.983	0.964	0.954

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.937	0.815	0.922	0.632
batch 2	0.825	0.672	0.887	0.676

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.4
HGNC	HGNC:3491
MGI	MGI:99253
EntrezGene (human)	GeneID:2116 (SSTAR profile)
EntrezGene (mouse)	GeneID:14008 (SSTAR profile)
UniProt ID (human)	ETV2_HUMAN
UniProt ID (mouse)	ETV2_MOUSE
UniProt AC (human)	O00321 (TFClass)
UniProt AC (mouse)	P41163 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 2 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	ETV2.H12RSNP.0.S.B.pcm
PWM	ETV2.H12RSNP.0.S.B.pwm
PFM	ETV2.H12RSNP.0.S.B.pfm
Alignment	ETV2.H12RSNP.0.S.B.words.tsv
Threshold to P-value map	ETV2.H12RSNP.0.S.B.thr
Motif in other formats
JASPAR format	ETV2.H12RSNP.0.S.B_jaspar_format.txt
MEME format	ETV2.H12RSNP.0.S.B_meme_format.meme
Transfac format	ETV2.H12RSNP.0.S.B_transfac_format.txt
Homer format	ETV2.H12RSNP.0.S.B_homer_format_0.001.txt ETV2.H12RSNP.0.S.B_homer_format_0.0005.txt ETV2.H12RSNP.0.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	339.25	161.25	137.25	172.25
02	587.0	62.0	56.0	105.0
03	32.0	711.0	65.0	2.0
04	49.0	757.0	1.0	3.0
05	0.0	0.0	810.0	0.0
06	0.0	0.0	810.0	0.0
07	802.0	0.0	0.0	8.0
08	724.0	4.0	10.0	72.0
09	407.0	31.0	356.0	16.0
10	71.0	167.0	69.0	503.0
11	257.0	79.0	323.0	151.0
12	245.25	165.25	264.25	135.25

PFM

	A	C	G	T
01	0.419	0.199	0.169	0.213
02	0.725	0.077	0.069	0.13
03	0.04	0.878	0.08	0.002
04	0.06	0.935	0.001	0.004
05	0.0	0.0	1.0	0.0
06	0.0	0.0	1.0	0.0
07	0.99	0.0	0.0	0.01
08	0.894	0.005	0.012	0.089
09	0.502	0.038	0.44	0.02
10	0.088	0.206	0.085	0.621
11	0.317	0.098	0.399	0.186
12	0.303	0.204	0.326	0.167

PWM

	A	C	G	T
01	0.513	-0.226	-0.385	-0.16
02	1.059	-1.165	-1.264	-0.649
03	-1.802	1.25	-1.119	-4.018
04	-1.394	1.313	-4.335	-3.777
05	-4.804	-4.804	1.38	-4.804
06	-4.804	-4.804	1.38	-4.804
07	1.37	-4.804	-4.804	-3.05
08	1.268	-3.583	-2.862	-1.019
09	0.694	-1.832	0.561	-2.447
10	-1.033	-0.191	-1.061	0.905
11	0.237	-0.929	0.464	-0.291
12	0.19	-0.201	0.264	-0.4

Standard thresholds

P-value	Threshold
0.001	3.78466
0.0005	4.962435
0.0001	7.310815