ETV2.H12INVITRO.0.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ETV2.H12INVITRO.0.S.B
Gene (human)	ETV2 (GeneCards)
Gene synonyms (human)	ER71, ETSRP71
Gene (mouse)	Etv2
Gene synonyms (mouse)	Er71, Etsrp71
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	nWCCGGAAGYdn
GC content	55.83%
Information content (bits; total / per base)	14.281 / 1.19
Data sources	HT-SELEX
Aligned words	6855

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (6)	0.942	0.945	0.856	0.859	0.889	0.892	2.857	2.891	185.475	202.824
Mouse	2 (13)	0.945	0.962	0.859	0.892	0.906	0.911	2.958	3.022	222.745	240.959

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.988	0.98	0.98	0.968	0.968	0.953
Overall, 3 experiments	best	0.995	0.992	0.99	0.984	0.969	0.959
Methyl HT-SELEX, 1 experiments	median	0.988	0.98	0.98	0.968	0.969	0.953
Methyl HT-SELEX, 1 experiments	best	0.988	0.98	0.98	0.968	0.969	0.953
Non-Methyl HT-SELEX, 2 experiments	median	0.764	0.767	0.749	0.751	0.736	0.734
Non-Methyl HT-SELEX, 2 experiments	best	0.995	0.992	0.99	0.984	0.968	0.959

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.923	0.809	0.915	0.604
batch 2	0.816	0.681	0.884	0.677

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.4
HGNC	HGNC:3491
MGI	MGI:99253
EntrezGene (human)	GeneID:2116 (SSTAR profile)
EntrezGene (mouse)	GeneID:14008 (SSTAR profile)
UniProt ID (human)	ETV2_HUMAN
UniProt ID (mouse)	ETV2_MOUSE
UniProt AC (human)	O00321 (TFClass)
UniProt AC (mouse)	P41163 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 2 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	ETV2.H12INVITRO.0.S.B.pcm
PWM	ETV2.H12INVITRO.0.S.B.pwm
PFM	ETV2.H12INVITRO.0.S.B.pfm
Alignment	ETV2.H12INVITRO.0.S.B.words.tsv
Threshold to P-value map	ETV2.H12INVITRO.0.S.B.thr
Motif in other formats
JASPAR format	ETV2.H12INVITRO.0.S.B_jaspar_format.txt
MEME format	ETV2.H12INVITRO.0.S.B_meme_format.meme
Transfac format	ETV2.H12INVITRO.0.S.B_transfac_format.txt
Homer format	ETV2.H12INVITRO.0.S.B_homer_format_0.001.txt ETV2.H12INVITRO.0.S.B_homer_format_0.0005.txt ETV2.H12INVITRO.0.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1932.75	1601.75	1568.75	1751.75
02	4641.75	223.75	833.75	1155.75
03	48.0	6544.0	263.0	0.0
04	40.0	6815.0	0.0	0.0
05	0.0	0.0	6855.0	0.0
06	0.0	0.0	6855.0	0.0
07	6855.0	0.0	0.0	0.0
08	6578.0	0.0	0.0	277.0
09	2139.0	8.0	4708.0	0.0
10	121.0	1722.0	170.0	4842.0
11	2128.25	777.25	2913.25	1036.25
12	1471.5	2046.5	2018.5	1318.5

PFM

	A	C	G	T
01	0.282	0.234	0.229	0.256
02	0.677	0.033	0.122	0.169
03	0.007	0.955	0.038	0.0
04	0.006	0.994	0.0	0.0
05	0.0	0.0	1.0	0.0
06	0.0	0.0	1.0	0.0
07	1.0	0.0	0.0	0.0
08	0.96	0.0	0.0	0.04
09	0.312	0.001	0.687	0.0
10	0.018	0.251	0.025	0.706
11	0.31	0.113	0.425	0.151
12	0.215	0.299	0.294	0.192

PWM

	A	C	G	T
01	0.12	-0.067	-0.088	0.022
02	0.996	-2.027	-0.719	-0.393
03	-3.532	1.339	-1.867	-6.656
04	-3.705	1.379	-6.656	-6.656
05	-6.656	-6.656	1.385	-6.656
06	-6.656	-6.656	1.385	-6.656
07	1.385	-6.656	-6.656	-6.656
08	1.344	-6.656	-6.656	-1.816
09	0.221	-5.125	1.01	-6.656
10	-2.634	0.005	-2.299	1.038
11	0.216	-0.789	0.53	-0.502
12	-0.152	0.177	0.163	-0.262

Standard thresholds

P-value	Threshold
0.001	1.135605
0.0005	2.745395
0.0001	6.613275