ETV2.H12CORE.1.PM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ETV2.H12CORE.1.PM.A
Gene (human)	ETV2 (GeneCards)
Gene synonyms (human)	ER71, ETSRP71
Gene (mouse)	Etv2
Gene synonyms (mouse)	Er71, Etsrp71
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	13
Consensus	ndRCAGGAARYdn
GC content	49.3%
Information content (bits; total / per base)	13.903 / 1.069
Data sources	ChIP-Seq + Methyl-HT-SELEX
Aligned words	9239

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (6)	0.94	0.943	0.869	0.874	0.94	0.942	3.842	3.852	220.906	240.678
Mouse	2 (13)	0.948	0.967	0.878	0.922	0.96	0.969	4.582	4.742	265.31	295.137

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.977	0.958	0.967	0.946	0.927	0.904
Overall, 3 experiments	best	0.997	0.995	0.994	0.991	0.978	0.972
Methyl HT-SELEX, 1 experiments	median	0.997	0.995	0.994	0.991	0.978	0.972
Methyl HT-SELEX, 1 experiments	best	0.997	0.995	0.994	0.991	0.978	0.972
Non-Methyl HT-SELEX, 2 experiments	median	0.757	0.746	0.741	0.731	0.715	0.706
Non-Methyl HT-SELEX, 2 experiments	best	0.977	0.958	0.967	0.946	0.927	0.904

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.902	0.53	0.867	0.57
batch 2	0.777	0.497	0.766	0.578

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.4
HGNC	HGNC:3491
MGI	MGI:99253
EntrezGene (human)	GeneID:2116 (SSTAR profile)
EntrezGene (mouse)	GeneID:14008 (SSTAR profile)
UniProt ID (human)	ETV2_HUMAN
UniProt ID (mouse)	ETV2_MOUSE
UniProt AC (human)	O00321 (TFClass)
UniProt AC (mouse)	P41163 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 2 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	ETV2.H12CORE.1.PM.A.pcm
PWM	ETV2.H12CORE.1.PM.A.pwm
PFM	ETV2.H12CORE.1.PM.A.pfm
Alignment	ETV2.H12CORE.1.PM.A.words.tsv
Threshold to P-value map	ETV2.H12CORE.1.PM.A.thr
Motif in other formats
JASPAR format	ETV2.H12CORE.1.PM.A_jaspar_format.txt
MEME format	ETV2.H12CORE.1.PM.A_meme_format.meme
Transfac format	ETV2.H12CORE.1.PM.A_transfac_format.txt
Homer format	ETV2.H12CORE.1.PM.A_homer_format_0.001.txt ETV2.H12CORE.1.PM.A_homer_format_0.0005.txt ETV2.H12CORE.1.PM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2928.5	1684.5	2944.5	1681.5
02	3468.25	1323.25	2881.25	1566.25
03	5938.0	206.0	2815.0	280.0
04	132.0	8700.0	333.0	74.0
05	8666.0	571.0	1.0	1.0
06	0.0	0.0	9239.0	0.0
07	0.0	0.0	9239.0	0.0
08	9239.0	0.0	0.0	0.0
09	8068.0	47.0	1.0	1123.0
10	3517.0	45.0	5670.0	7.0
11	179.0	1983.0	302.0	6775.0
12	2828.5	915.5	4423.5	1071.5
13	1726.75	2417.75	3471.75	1622.75

PFM

	A	C	G	T
01	0.317	0.182	0.319	0.182
02	0.375	0.143	0.312	0.17
03	0.643	0.022	0.305	0.03
04	0.014	0.942	0.036	0.008
05	0.938	0.062	0.0	0.0
06	0.0	0.0	1.0	0.0
07	0.0	0.0	1.0	0.0
08	1.0	0.0	0.0	0.0
09	0.873	0.005	0.0	0.122
10	0.381	0.005	0.614	0.001
11	0.019	0.215	0.033	0.733
12	0.306	0.099	0.479	0.116
13	0.187	0.262	0.376	0.176

PWM

	A	C	G	T
01	0.237	-0.315	0.243	-0.317
02	0.406	-0.556	0.221	-0.388
03	0.944	-2.407	0.198	-2.103
04	-2.846	1.325	-1.931	-3.411
05	1.322	-1.395	-6.557	-6.557
06	-6.92	-6.92	1.386	-6.92
07	-6.92	-6.92	1.386	-6.92
08	1.386	-6.92	-6.92	-6.92
09	1.25	-3.848	-6.557	-0.72
10	0.42	-3.89	0.897	-5.518
11	-2.546	-0.152	-2.028	1.075
12	0.202	-0.924	0.649	-0.767
13	-0.291	0.046	0.407	-0.353

Standard thresholds

P-value	Threshold
0.001	2.05711
0.0005	3.701085
0.0001	6.90114