ETV2.H12CORE.0.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ETV2.H12CORE.0.S.B
Gene (human)	ETV2 (GeneCards)
Gene synonyms (human)	ER71, ETSRP71
Gene (mouse)	Etv2
Gene synonyms (mouse)	Er71, Etsrp71
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	11
Consensus	hMMGGAARbdn
GC content	50.86%
Information content (bits; total / per base)	9.952 / 0.905
Data sources	HT-SELEX
Aligned words	1614

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (6)	0.958	0.959	0.903	0.905	0.919	0.921	3.212	3.247	195.914	227.237
Mouse	2 (13)	0.957	0.969	0.889	0.927	0.94	0.943	3.549	3.592	247.284	281.237

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.991	0.985	0.987	0.98	0.957	0.947
Overall, 3 experiments	best	0.994	0.99	0.988	0.981	0.972	0.961
Methyl HT-SELEX, 1 experiments	median	0.991	0.985	0.988	0.98	0.972	0.961
Methyl HT-SELEX, 1 experiments	best	0.991	0.985	0.988	0.98	0.972	0.961
Non-Methyl HT-SELEX, 2 experiments	median	0.772	0.77	0.756	0.754	0.736	0.732
Non-Methyl HT-SELEX, 2 experiments	best	0.994	0.99	0.987	0.981	0.957	0.947

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.938	0.7	0.913	0.612
batch 2	0.799	0.597	0.855	0.644

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.4
HGNC	HGNC:3491
MGI	MGI:99253
EntrezGene (human)	GeneID:2116 (SSTAR profile)
EntrezGene (mouse)	GeneID:14008 (SSTAR profile)
UniProt ID (human)	ETV2_HUMAN
UniProt ID (mouse)	ETV2_MOUSE
UniProt AC (human)	O00321 (TFClass)
UniProt AC (mouse)	P41163 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 2 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	ETV2.H12CORE.0.S.B.pcm
PWM	ETV2.H12CORE.0.S.B.pwm
PFM	ETV2.H12CORE.0.S.B.pfm
Alignment	ETV2.H12CORE.0.S.B.words.tsv
Threshold to P-value map	ETV2.H12CORE.0.S.B.thr
Motif in other formats
JASPAR format	ETV2.H12CORE.0.S.B_jaspar_format.txt
MEME format	ETV2.H12CORE.0.S.B_meme_format.meme
Transfac format	ETV2.H12CORE.0.S.B_transfac_format.txt
Homer format	ETV2.H12CORE.0.S.B_homer_format_0.001.txt ETV2.H12CORE.0.S.B_homer_format_0.0005.txt ETV2.H12CORE.0.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	873.5	235.5	217.5	287.5
02	261.25	1060.25	219.25	73.25
03	303.0	1199.0	31.0	81.0
04	0.0	0.0	1571.0	43.0
05	0.0	0.0	1610.0	4.0
06	1577.0	0.0	0.0	37.0
07	1422.0	12.0	41.0	139.0
08	840.0	76.0	668.0	30.0
09	186.0	290.0	215.0	923.0
10	536.0	181.0	590.0	307.0
11	507.75	302.75	509.75	293.75

PFM

	A	C	G	T
01	0.541	0.146	0.135	0.178
02	0.162	0.657	0.136	0.045
03	0.188	0.743	0.019	0.05
04	0.0	0.0	0.973	0.027
05	0.0	0.0	0.998	0.002
06	0.977	0.0	0.0	0.023
07	0.881	0.007	0.025	0.086
08	0.52	0.047	0.414	0.019
09	0.115	0.18	0.133	0.572
10	0.332	0.112	0.366	0.19
11	0.315	0.188	0.316	0.182

PWM

	A	C	G	T
01	0.77	-0.535	-0.614	-0.337
02	-0.432	0.963	-0.606	-1.686
03	-0.285	1.086	-2.513	-1.588
04	-5.391	-5.391	1.356	-2.201
05	-5.391	-5.391	1.38	-4.239
06	1.36	-5.391	-5.391	-2.345
07	1.256	-3.377	-2.247	-1.057
08	0.731	-1.65	0.502	-2.544
09	-0.769	-0.329	-0.626	0.825
10	0.283	-0.796	0.379	-0.272
11	0.229	-0.286	0.233	-0.316

Standard thresholds

P-value	Threshold
0.001	4.884555
0.0005	5.77902
0.0001	7.43556