ETV1.H12RSNP.1.PM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ETV1.H12RSNP.1.PM.A
Gene (human)	ETV1 (GeneCards)
Gene synonyms (human)	ER81
Gene (mouse)	Etv1
Gene synonyms (mouse)	Er81, Etsrp81
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	13
Consensus	ndRMAGGAAGYdn
GC content	53.79%
Information content (bits; total / per base)	13.194 / 1.015
Data sources	ChIP-Seq + Methyl-HT-SELEX
Aligned words	8683

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	8 (55)	0.857	0.895	0.721	0.802	0.858	0.89	2.857	3.188	148.538	256.125

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.984	0.971	0.961	0.946	0.823	0.837
Overall, 8 experiments	best	0.995	0.991	0.984	0.977	0.966	0.951
Methyl HT-SELEX, 3 experiments	median	0.951	0.928	0.862	0.839	0.724	0.728
Methyl HT-SELEX, 3 experiments	best	0.991	0.986	0.983	0.973	0.964	0.95
Non-Methyl HT-SELEX, 5 experiments	median	0.99	0.981	0.971	0.95	0.863	0.872
Non-Methyl HT-SELEX, 5 experiments	best	0.995	0.991	0.984	0.977	0.966	0.951

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	10.929	3.461	0.245	0.204

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.968	0.829	0.919	0.565
batch 2	0.73	0.419	0.753	0.532

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ELK-like {3.5.2.2} (TFClass)
TFClass ID	TFClass: 3.5.2.2.4
HGNC	HGNC:3490
MGI	MGI:99254
EntrezGene (human)	GeneID:2115 (SSTAR profile)
EntrezGene (mouse)	GeneID:14009 (SSTAR profile)
UniProt ID (human)	ETV1_HUMAN
UniProt ID (mouse)	ETV1_MOUSE
UniProt AC (human)	P50549 (TFClass)
UniProt AC (mouse)	P41164 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	8 human, 0 mouse
HT-SELEX	5
Methyl-HT-SELEX	3

PCM	ETV1.H12RSNP.1.PM.A.pcm
PWM	ETV1.H12RSNP.1.PM.A.pwm
PFM	ETV1.H12RSNP.1.PM.A.pfm
Alignment	ETV1.H12RSNP.1.PM.A.words.tsv
Threshold to P-value map	ETV1.H12RSNP.1.PM.A.thr
Motif in other formats
JASPAR format	ETV1.H12RSNP.1.PM.A_jaspar_format.txt
MEME format	ETV1.H12RSNP.1.PM.A_meme_format.meme
Transfac format	ETV1.H12RSNP.1.PM.A_transfac_format.txt
Homer format	ETV1.H12RSNP.1.PM.A_homer_format_0.001.txt ETV1.H12RSNP.1.PM.A_homer_format_0.0005.txt ETV1.H12RSNP.1.PM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2836.0	1908.0	2443.0	1496.0
02	1956.5	1110.5	4166.5	1449.5
03	3550.0	127.0	4296.0	710.0
04	1862.0	5607.0	1120.0	94.0
05	6288.0	2353.0	41.0	1.0
06	0.0	0.0	8683.0	0.0
07	0.0	0.0	8683.0	0.0
08	8683.0	0.0	0.0	0.0
09	7756.0	0.0	0.0	927.0
10	120.0	6.0	8557.0	0.0
11	48.0	1361.0	1204.0	6070.0
12	3516.75	482.75	3802.75	880.75
13	2241.75	1922.75	2847.75	1670.75

PFM

	A	C	G	T
01	0.327	0.22	0.281	0.172
02	0.225	0.128	0.48	0.167
03	0.409	0.015	0.495	0.082
04	0.214	0.646	0.129	0.011
05	0.724	0.271	0.005	0.0
06	0.0	0.0	1.0	0.0
07	0.0	0.0	1.0	0.0
08	1.0	0.0	0.0	0.0
09	0.893	0.0	0.0	0.107
10	0.014	0.001	0.985	0.0
11	0.006	0.157	0.139	0.699
12	0.405	0.056	0.438	0.101
13	0.258	0.221	0.328	0.192

PWM

	A	C	G	T
01	0.267	-0.129	0.118	-0.372
02	-0.104	-0.669	0.652	-0.403
03	0.491	-2.822	0.682	-1.115
04	-0.153	0.948	-0.661	-3.117
05	1.063	0.081	-3.916	-6.5
06	-6.865	-6.865	1.386	-6.865
07	-6.865	-6.865	1.386	-6.865
08	1.386	-6.865	-6.865	-6.865
09	1.273	-6.865	-6.865	-0.849
10	-2.878	-5.572	1.371	-6.865
11	-3.767	-0.466	-0.589	1.028
12	0.482	-1.5	0.56	-0.901
13	0.032	-0.121	0.271	-0.261

Standard thresholds

P-value	Threshold
0.001	2.11356
0.0005	4.03121
0.0001	7.35067