ETS1.H12RSNP.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ETS1.H12RSNP.1.P.B
Gene (human)	ETS1 (GeneCards)
Gene synonyms (human)	EWSR2
Gene (mouse)	Ets1
Gene synonyms (mouse)	Ets-1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	13
Consensus	vnvSMGGAAGTRS
GC content	58.73%
Information content (bits; total / per base)	13.094 / 1.007
Data sources	ChIP-Seq
Aligned words	916

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	19 (119)	0.808	0.946	0.715	0.897	0.816	0.947	2.952	4.385	68.268	241.229
Mouse	13 (75)	0.844	0.946	0.779	0.918	0.848	0.944	3.385	4.554	95.31	326.268

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 4 experiments	median	0.785	0.76	0.637	0.645	0.563	0.583
Non-Methyl HT-SELEX, 4 experiments	best	0.968	0.952	0.832	0.831	0.67	0.701

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	11.89	30.081	0.464	0.313

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.1
HGNC	HGNC:3488
MGI	MGI:95455
EntrezGene (human)	GeneID:2113 (SSTAR profile)
EntrezGene (mouse)	GeneID:23871 (SSTAR profile)
UniProt ID (human)	ETS1_HUMAN
UniProt ID (mouse)	ETS1_MOUSE
UniProt AC (human)	P14921 (TFClass)
UniProt AC (mouse)	P27577 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	19 human, 13 mouse
HT-SELEX	4
Methyl-HT-SELEX	0

PCM	ETS1.H12RSNP.1.P.B.pcm
PWM	ETS1.H12RSNP.1.P.B.pwm
PFM	ETS1.H12RSNP.1.P.B.pfm
Alignment	ETS1.H12RSNP.1.P.B.words.tsv
Threshold to P-value map	ETS1.H12RSNP.1.P.B.thr
Motif in other formats
JASPAR format	ETS1.H12RSNP.1.P.B_jaspar_format.txt
MEME format	ETS1.H12RSNP.1.P.B_meme_format.meme
Transfac format	ETS1.H12RSNP.1.P.B_transfac_format.txt
Homer format	ETS1.H12RSNP.1.P.B_homer_format_0.001.txt ETS1.H12RSNP.1.P.B_homer_format_0.0005.txt ETS1.H12RSNP.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	275.0	292.0	259.0	90.0
02	191.0	277.0	318.0	130.0
03	484.0	108.0	264.0	60.0
04	58.0	676.0	169.0	13.0
05	534.0	377.0	3.0	2.0
06	8.0	0.0	906.0	2.0
07	10.0	1.0	902.0	3.0
08	911.0	1.0	1.0	3.0
09	688.0	8.0	4.0	216.0
10	105.0	4.0	804.0	3.0
11	29.0	138.0	18.0	731.0
12	117.0	52.0	652.0	95.0
13	106.0	114.0	645.0	51.0

PFM

	A	C	G	T
01	0.3	0.319	0.283	0.098
02	0.209	0.302	0.347	0.142
03	0.528	0.118	0.288	0.066
04	0.063	0.738	0.184	0.014
05	0.583	0.412	0.003	0.002
06	0.009	0.0	0.989	0.002
07	0.011	0.001	0.985	0.003
08	0.995	0.001	0.001	0.003
09	0.751	0.009	0.004	0.236
10	0.115	0.004	0.878	0.003
11	0.032	0.151	0.02	0.798
12	0.128	0.057	0.712	0.104
13	0.116	0.124	0.704	0.056

PWM

	A	C	G	T
01	0.182	0.241	0.122	-0.923
02	-0.18	0.189	0.326	-0.561
03	0.744	-0.743	0.141	-1.319
04	-1.352	1.078	-0.301	-2.753
05	0.842	0.496	-3.893	-4.131
06	-3.168	-4.908	1.37	-4.131
07	-2.981	-4.446	1.365	-3.893
08	1.375	-4.446	-4.446	-3.893
09	1.095	-3.168	-3.7	-0.058
10	-0.771	-3.7	1.251	-3.893
11	-2.017	-0.502	-2.46	1.156
12	-0.664	-1.458	1.042	-0.869
13	-0.762	-0.69	1.031	-1.476

Standard thresholds

P-value	Threshold
0.001	3.604515
0.0005	4.769875
0.0001	7.13732