ETS1.H12RSNP.0.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ETS1.H12RSNP.0.S.B
Gene (human)	ETS1 (GeneCards)
Gene synonyms (human)	EWSR2
Gene (mouse)	Ets1
Gene synonyms (mouse)	Ets-1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	nRCCGGAAGYdn
GC content	55.74%
Information content (bits; total / per base)	13.769 / 1.147
Data sources	HT-SELEX
Aligned words	8205

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	19 (119)	0.841	0.947	0.754	0.897	0.795	0.91	2.469	3.375	83.721	241.495
Mouse	13 (75)	0.861	0.949	0.775	0.901	0.834	0.92	2.798	3.6	100.194	293.027

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 4 experiments	median	0.81	0.806	0.636	0.661	0.558	0.59
Non-Methyl HT-SELEX, 4 experiments	best	0.991	0.986	0.84	0.853	0.666	0.71

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	10.446	26.606	0.412	0.29

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.1
HGNC	HGNC:3488
MGI	MGI:95455
EntrezGene (human)	GeneID:2113 (SSTAR profile)
EntrezGene (mouse)	GeneID:23871 (SSTAR profile)
UniProt ID (human)	ETS1_HUMAN
UniProt ID (mouse)	ETS1_MOUSE
UniProt AC (human)	P14921 (TFClass)
UniProt AC (mouse)	P27577 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	19 human, 13 mouse
HT-SELEX	4
Methyl-HT-SELEX	0

PCM	ETS1.H12RSNP.0.S.B.pcm
PWM	ETS1.H12RSNP.0.S.B.pwm
PFM	ETS1.H12RSNP.0.S.B.pfm
Alignment	ETS1.H12RSNP.0.S.B.words.tsv
Threshold to P-value map	ETS1.H12RSNP.0.S.B.thr
Motif in other formats
JASPAR format	ETS1.H12RSNP.0.S.B_jaspar_format.txt
MEME format	ETS1.H12RSNP.0.S.B_meme_format.meme
Transfac format	ETS1.H12RSNP.0.S.B_transfac_format.txt
Homer format	ETS1.H12RSNP.0.S.B_homer_format_0.001.txt ETS1.H12RSNP.0.S.B_homer_format_0.0005.txt ETS1.H12RSNP.0.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2434.25	1815.25	2377.25	1578.25
02	6431.0	260.0	1121.0	393.0
03	152.0	7661.0	366.0	26.0
04	357.0	7835.0	11.0	2.0
05	0.0	1.0	8203.0	1.0
06	0.0	0.0	8203.0	2.0
07	8204.0	0.0	0.0	1.0
08	6631.0	16.0	15.0	1543.0
09	2285.0	63.0	5824.0	33.0
10	156.0	1665.0	228.0	6156.0
11	2566.5	1060.5	3463.5	1114.5
12	2118.75	2513.75	2179.75	1392.75

PFM

	A	C	G	T
01	0.297	0.221	0.29	0.192
02	0.784	0.032	0.137	0.048
03	0.019	0.934	0.045	0.003
04	0.044	0.955	0.001	0.0
05	0.0	0.0	1.0	0.0
06	0.0	0.0	1.0	0.0
07	1.0	0.0	0.0	0.0
08	0.808	0.002	0.002	0.188
09	0.278	0.008	0.71	0.004
10	0.019	0.203	0.028	0.75
11	0.313	0.129	0.422	0.136
12	0.258	0.306	0.266	0.17

PWM

	A	C	G	T
01	0.171	-0.122	0.147	-0.262
02	1.142	-2.058	-0.603	-1.648
03	-2.589	1.317	-1.719	-4.286
04	-1.743	1.339	-5.043	-6.18
05	-6.815	-6.448	1.385	-6.448
06	-6.815	-6.815	1.385	-6.18
07	1.385	-6.815	-6.815	-6.448
08	1.173	-4.723	-4.779	-0.284
09	0.108	-3.449	1.043	-4.065
10	-2.563	-0.208	-2.188	1.098
11	0.224	-0.659	0.523	-0.609
12	0.032	0.203	0.061	-0.387

Standard thresholds

P-value	Threshold
0.001	2.325635
0.0005	3.880745
0.0001	6.959305