ETS1.H12INVIVO.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ETS1.H12INVIVO.1.P.B
Gene (human)	ETS1 (GeneCards)
Gene synonyms (human)	EWSR2
Gene (mouse)	Ets1
Gene synonyms (mouse)	Ets-1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	13
Consensus	vvRSMGGAAGYSv
GC content	59.05%
Information content (bits; total / per base)	12.128 / 0.933
Data sources	ChIP-Seq
Aligned words	1002

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	19 (119)	0.816	0.945	0.725	0.885	0.822	0.943	2.974	4.244	74.252	239.538
Mouse	13 (75)	0.85	0.945	0.778	0.912	0.854	0.943	3.374	4.324	98.167	312.721

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 4 experiments	median	0.79	0.763	0.638	0.646	0.563	0.584
Non-Methyl HT-SELEX, 4 experiments	best	0.965	0.946	0.833	0.83	0.671	0.701

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	10.665	27.761	0.447	0.305

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.1
HGNC	HGNC:3488
MGI	MGI:95455
EntrezGene (human)	GeneID:2113 (SSTAR profile)
EntrezGene (mouse)	GeneID:23871 (SSTAR profile)
UniProt ID (human)	ETS1_HUMAN
UniProt ID (mouse)	ETS1_MOUSE
UniProt AC (human)	P14921 (TFClass)
UniProt AC (mouse)	P27577 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	19 human, 13 mouse
HT-SELEX	4
Methyl-HT-SELEX	0

PCM	ETS1.H12INVIVO.1.P.B.pcm
PWM	ETS1.H12INVIVO.1.P.B.pwm
PFM	ETS1.H12INVIVO.1.P.B.pfm
Alignment	ETS1.H12INVIVO.1.P.B.words.tsv
Threshold to P-value map	ETS1.H12INVIVO.1.P.B.thr
Motif in other formats
JASPAR format	ETS1.H12INVIVO.1.P.B_jaspar_format.txt
MEME format	ETS1.H12INVIVO.1.P.B_meme_format.meme
Transfac format	ETS1.H12INVIVO.1.P.B_transfac_format.txt
Homer format	ETS1.H12INVIVO.1.P.B_homer_format_0.001.txt ETS1.H12INVIVO.1.P.B_homer_format_0.0005.txt ETS1.H12INVIVO.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	342.0	258.0	296.0	106.0
02	255.0	218.0	423.0	106.0
03	451.0	82.0	424.0	45.0
04	90.0	690.0	214.0	8.0
05	586.0	402.0	11.0	3.0
06	2.0	0.0	998.0	2.0
07	4.0	2.0	996.0	0.0
08	996.0	0.0	5.0	1.0
09	785.0	11.0	3.0	203.0
10	163.0	11.0	824.0	4.0
11	56.0	243.0	53.0	650.0
12	96.0	155.0	613.0	138.0
13	157.0	174.0	586.0	85.0

PFM

	A	C	G	T
01	0.341	0.257	0.295	0.106
02	0.254	0.218	0.422	0.106
03	0.45	0.082	0.423	0.045
04	0.09	0.689	0.214	0.008
05	0.585	0.401	0.011	0.003
06	0.002	0.0	0.996	0.002
07	0.004	0.002	0.994	0.0
08	0.994	0.0	0.005	0.001
09	0.783	0.011	0.003	0.203
10	0.163	0.011	0.822	0.004
11	0.056	0.243	0.053	0.649
12	0.096	0.155	0.612	0.138
13	0.157	0.174	0.585	0.085

PWM

	A	C	G	T
01	0.31	0.029	0.166	-0.851
02	0.018	-0.138	0.521	-0.851
03	0.585	-1.103	0.523	-1.686
04	-1.012	1.009	-0.156	-3.255
05	0.846	0.47	-2.987	-3.977
06	-4.215	-4.984	1.377	-4.215
07	-3.785	-4.215	1.375	-4.984
08	1.375	-4.984	-3.624	-4.527
09	1.138	-2.987	-3.977	-0.209
10	-0.426	-2.987	1.186	-3.785
11	-1.475	-0.03	-1.528	0.949
12	-0.948	-0.476	0.891	-0.591
13	-0.463	-0.361	0.846	-1.068

Standard thresholds

P-value	Threshold
0.001	3.97306
0.0005	5.15471
0.0001	7.40057