ETS1.H12INVIVO.0.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ETS1.H12INVIVO.0.S.B
Gene (human)	ETS1 (GeneCards)
Gene synonyms (human)	EWSR2
Gene (mouse)	Ets1
Gene synonyms (mouse)	Ets-1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	nRCCGGAARYdn
GC content	55.73%
Information content (bits; total / per base)	12.414 / 1.035
Data sources	HT-SELEX
Aligned words	9950

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	19 (119)	0.843	0.948	0.76	0.899	0.797	0.91	2.478	3.388	83.538	251.367
Mouse	13 (75)	0.864	0.95	0.777	0.904	0.835	0.919	2.808	3.613	103.796	294.036

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 4 experiments	median	0.81	0.806	0.636	0.661	0.557	0.589
Non-Methyl HT-SELEX, 4 experiments	best	0.991	0.986	0.84	0.853	0.668	0.711

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	10.321	26.468	0.401	0.286

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.1
HGNC	HGNC:3488
MGI	MGI:95455
EntrezGene (human)	GeneID:2113 (SSTAR profile)
EntrezGene (mouse)	GeneID:23871 (SSTAR profile)
UniProt ID (human)	ETS1_HUMAN
UniProt ID (mouse)	ETS1_MOUSE
UniProt AC (human)	P14921 (TFClass)
UniProt AC (mouse)	P27577 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	19 human, 13 mouse
HT-SELEX	4
Methyl-HT-SELEX	0

PCM	ETS1.H12INVIVO.0.S.B.pcm
PWM	ETS1.H12INVIVO.0.S.B.pwm
PFM	ETS1.H12INVIVO.0.S.B.pfm
Alignment	ETS1.H12INVIVO.0.S.B.words.tsv
Threshold to P-value map	ETS1.H12INVIVO.0.S.B.thr
Motif in other formats
JASPAR format	ETS1.H12INVIVO.0.S.B_jaspar_format.txt
MEME format	ETS1.H12INVIVO.0.S.B_meme_format.meme
Transfac format	ETS1.H12INVIVO.0.S.B_transfac_format.txt
Homer format	ETS1.H12INVIVO.0.S.B_homer_format_0.001.txt ETS1.H12INVIVO.0.S.B_homer_format_0.0005.txt ETS1.H12INVIVO.0.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2928.5	2202.5	2877.5	1941.5
02	6989.75	504.75	1621.75	833.75
03	427.0	8661.0	732.0	130.0
04	742.0	9025.0	150.0	33.0
05	3.0	4.0	9929.0	14.0
06	1.0	0.0	9938.0	11.0
07	9918.0	5.0	4.0	23.0
08	7809.0	63.0	63.0	2015.0
09	2813.0	182.0	6831.0	124.0
10	387.0	2231.0	469.0	6863.0
11	3077.5	1380.5	4016.5	1475.5
12	2526.25	3074.25	2582.25	1767.25

PFM

	A	C	G	T
01	0.294	0.221	0.289	0.195
02	0.702	0.051	0.163	0.084
03	0.043	0.87	0.074	0.013
04	0.075	0.907	0.015	0.003
05	0.0	0.0	0.998	0.001
06	0.0	0.0	0.999	0.001
07	0.997	0.001	0.0	0.002
08	0.785	0.006	0.006	0.203
09	0.283	0.018	0.687	0.012
10	0.039	0.224	0.047	0.69
11	0.309	0.139	0.404	0.148
12	0.254	0.309	0.26	0.178

PWM

	A	C	G	T
01	0.163	-0.122	0.146	-0.248
02	1.033	-1.591	-0.427	-1.091
03	-1.758	1.247	-1.221	-2.935
04	-1.208	1.288	-2.794	-4.256
05	-6.152	-5.979	1.383	-5.029
06	-6.626	-6.986	1.384	-5.232
07	1.382	-5.832	-5.979	-4.589
08	1.143	-3.641	-3.641	-0.21
09	0.123	-2.603	1.01	-2.981
10	-1.856	-0.109	-1.664	1.014
11	0.213	-0.588	0.479	-0.522
12	0.015	0.212	0.037	-0.341

Standard thresholds

P-value	Threshold
0.001	3.660365
0.0005	4.928765
0.0001	7.33989