ETS1.H12INVITRO.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ETS1.H12INVITRO.1.P.B
Gene (human)	ETS1 (GeneCards)
Gene synonyms (human)	EWSR2
Gene (mouse)	Ets1
Gene synonyms (mouse)	Ets-1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	12
Consensus	vvSMGGAAGYRv
GC content	58.36%
Information content (bits; total / per base)	11.909 / 0.992
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	19 (119)	0.82	0.943	0.722	0.872	0.822	0.935	2.899	3.953	72.081	226.119
Mouse	13 (75)	0.847	0.941	0.767	0.903	0.85	0.938	3.273	4.163	94.143	289.678

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 4 experiments	median	0.787	0.762	0.641	0.647	0.566	0.585
Non-Methyl HT-SELEX, 4 experiments	best	0.966	0.95	0.833	0.83	0.673	0.702

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	14.49	31.913	0.437	0.301

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.1
HGNC	HGNC:3488
MGI	MGI:95455
EntrezGene (human)	GeneID:2113 (SSTAR profile)
EntrezGene (mouse)	GeneID:23871 (SSTAR profile)
UniProt ID (human)	ETS1_HUMAN
UniProt ID (mouse)	ETS1_MOUSE
UniProt AC (human)	P14921 (TFClass)
UniProt AC (mouse)	P27577 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	19 human, 13 mouse
HT-SELEX	4
Methyl-HT-SELEX	0

PCM	ETS1.H12INVITRO.1.P.B.pcm
PWM	ETS1.H12INVITRO.1.P.B.pwm
PFM	ETS1.H12INVITRO.1.P.B.pfm
Alignment	ETS1.H12INVITRO.1.P.B.words.tsv
Threshold to P-value map	ETS1.H12INVITRO.1.P.B.thr
Motif in other formats
JASPAR format	ETS1.H12INVITRO.1.P.B_jaspar_format.txt
MEME format	ETS1.H12INVITRO.1.P.B_meme_format.meme
Transfac format	ETS1.H12INVITRO.1.P.B_transfac_format.txt
Homer format	ETS1.H12INVITRO.1.P.B_homer_format_0.001.txt ETS1.H12INVITRO.1.P.B_homer_format_0.0005.txt ETS1.H12INVITRO.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	257.0	261.0	368.0	114.0
02	446.0	136.0	369.0	49.0
03	88.0	684.0	214.0	14.0
04	514.0	452.0	28.0	6.0
05	2.0	0.0	995.0	3.0
06	4.0	1.0	995.0	0.0
07	989.0	6.0	4.0	1.0
08	928.0	0.0	4.0	68.0
09	214.0	17.0	766.0	3.0
10	107.0	209.0	53.0	631.0
11	117.0	86.0	686.0	111.0
12	242.0	175.0	494.0	89.0

PFM

	A	C	G	T
01	0.257	0.261	0.368	0.114
02	0.446	0.136	0.369	0.049
03	0.088	0.684	0.214	0.014
04	0.514	0.452	0.028	0.006
05	0.002	0.0	0.995	0.003
06	0.004	0.001	0.995	0.0
07	0.989	0.006	0.004	0.001
08	0.928	0.0	0.004	0.068
09	0.214	0.017	0.766	0.003
10	0.107	0.209	0.053	0.631
11	0.117	0.086	0.686	0.111
12	0.242	0.175	0.494	0.089

PWM

	A	C	G	T
01	0.027	0.043	0.384	-0.777
02	0.576	-0.603	0.387	-1.602
03	-1.032	1.002	-0.154	-2.773
04	0.717	0.589	-2.136	-3.484
05	-4.213	-4.982	1.376	-3.975
06	-3.783	-4.525	1.376	-4.982
07	1.37	-3.484	-3.783	-4.525
08	1.307	-4.982	-3.783	-1.284
09	-0.154	-2.598	1.115	-3.975
10	-0.84	-0.178	-1.526	0.922
11	-0.752	-1.054	1.005	-0.803
12	-0.032	-0.354	0.678	-1.02

Standard thresholds

P-value	Threshold
0.001	4.059615
0.0005	5.227535
0.0001	7.434315