ESX1.H12RSNP.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ESX1.H12RSNP.1.S.B
Gene (human)	ESX1 (GeneCards)
Gene synonyms (human)	ESX1L, ESX1R
Gene (mouse)
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	20
Consensus	nnhWWWWnRYTAATTASbvn
GC content	30.01%
Information content (bits; total / per base)	16.045 / 0.802
Data sources	HT-SELEX
Aligned words	370

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.965	0.94	0.948	0.916	0.922	0.884
Overall, 10 experiments	best	0.993	0.988	0.989	0.982	0.975	0.965
Methyl HT-SELEX, 3 experiments	median	0.959	0.928	0.949	0.915	0.924	0.888
Methyl HT-SELEX, 3 experiments	best	0.976	0.957	0.97	0.949	0.956	0.931
Non-Methyl HT-SELEX, 7 experiments	median	0.971	0.953	0.946	0.917	0.92	0.881
Non-Methyl HT-SELEX, 7 experiments	best	0.993	0.988	0.989	0.982	0.975	0.965

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.978	0.389	0.963	0.604
batch 2	0.688	0.463	0.736	0.527

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	Paired-related HD {3.1.3} (TFClass)
TF subfamily	ESX {3.1.3.8} (TFClass)
TFClass ID	TFClass: 3.1.3.8.1
HGNC	HGNC:14865
MGI
EntrezGene (human)	GeneID:80712 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	ESX1_HUMAN
UniProt ID (mouse)
UniProt AC (human)	Q8N693 (TFClass)
UniProt AC (mouse)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	ESX1.H12RSNP.1.S.B.pcm
PWM	ESX1.H12RSNP.1.S.B.pwm
PFM	ESX1.H12RSNP.1.S.B.pfm
Alignment	ESX1.H12RSNP.1.S.B.words.tsv
Threshold to P-value map	ESX1.H12RSNP.1.S.B.thr
Motif in other formats
JASPAR format	ESX1.H12RSNP.1.S.B_jaspar_format.txt
MEME format	ESX1.H12RSNP.1.S.B_meme_format.meme
Transfac format	ESX1.H12RSNP.1.S.B_transfac_format.txt
Homer format	ESX1.H12RSNP.1.S.B_homer_format_0.001.txt ESX1.H12RSNP.1.S.B_homer_format_0.0005.txt ESX1.H12RSNP.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	79.5	129.5	53.5	107.5
02	97.5	113.5	45.5	113.5
03	130.0	65.0	29.0	146.0
04	199.0	3.0	12.0	156.0
05	220.0	9.0	16.0	125.0
06	136.0	22.0	19.0	193.0
07	73.0	32.0	41.0	224.0
08	107.0	70.0	97.0	96.0
09	178.0	45.0	135.0	12.0
10	1.0	221.0	31.0	117.0
11	0.0	65.0	0.0	305.0
12	369.0	0.0	1.0	0.0
13	370.0	0.0	0.0	0.0
14	0.0	0.0	0.0	370.0
15	0.0	1.0	0.0	369.0
16	355.0	0.0	15.0	0.0
17	56.0	61.0	247.0	6.0
18	39.0	161.0	68.0	102.0
19	93.0	57.0	165.0	55.0
20	125.0	85.0	106.0	54.0

PFM

	A	C	G	T
01	0.215	0.35	0.145	0.291
02	0.264	0.307	0.123	0.307
03	0.351	0.176	0.078	0.395
04	0.538	0.008	0.032	0.422
05	0.595	0.024	0.043	0.338
06	0.368	0.059	0.051	0.522
07	0.197	0.086	0.111	0.605
08	0.289	0.189	0.262	0.259
09	0.481	0.122	0.365	0.032
10	0.003	0.597	0.084	0.316
11	0.0	0.176	0.0	0.824
12	0.997	0.0	0.003	0.0
13	1.0	0.0	0.0	0.0
14	0.0	0.0	0.0	1.0
15	0.0	0.003	0.0	0.997
16	0.959	0.0	0.041	0.0
17	0.151	0.165	0.668	0.016
18	0.105	0.435	0.184	0.276
19	0.251	0.154	0.446	0.149
20	0.338	0.23	0.286	0.146

PWM

	A	C	G	T
01	-0.149	0.332	-0.536	0.148
02	0.052	0.202	-0.693	0.202
03	0.336	-0.346	-1.126	0.451
04	0.758	-3.044	-1.942	0.516
05	0.857	-2.194	-1.682	0.297
06	0.38	-1.387	-1.524	0.727
07	-0.233	-1.032	-0.794	0.875
08	0.143	-0.274	0.047	0.037
09	0.647	-0.704	0.373	-1.942
10	-3.635	0.862	-1.062	0.232
11	-4.152	-0.346	-4.152	1.182
12	1.372	-4.152	-3.635	-4.152
13	1.374	-4.152	-4.152	-4.152
14	-4.152	-4.152	-4.152	1.374
15	-4.152	-3.635	-4.152	1.372
16	1.333	-4.152	-1.741	-4.152
17	-0.492	-0.408	0.972	-2.531
18	-0.842	0.547	-0.302	0.096
19	0.005	-0.474	0.572	-0.509
20	0.297	-0.083	0.134	-0.527

Standard thresholds

P-value	Threshold
0.001	2.18616
0.0005	3.52971
0.0001	6.30491