ESX1.H12RSNP.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ESX1.H12RSNP.0.SM.B
Gene (human)	ESX1 (GeneCards)
Gene synonyms (human)	ESX1L, ESX1R
Gene (mouse)
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	11
Consensus	nnYRATTAvbn
GC content	34.0%
Information content (bits; total / per base)	10.1 / 0.918
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9732

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.973	0.955	0.962	0.939	0.939	0.913
Overall, 10 experiments	best	0.992	0.986	0.986	0.978	0.975	0.963
Methyl HT-SELEX, 3 experiments	median	0.974	0.958	0.963	0.941	0.941	0.914
Methyl HT-SELEX, 3 experiments	best	0.987	0.979	0.982	0.97	0.971	0.956
Non-Methyl HT-SELEX, 7 experiments	median	0.972	0.952	0.962	0.938	0.936	0.912
Non-Methyl HT-SELEX, 7 experiments	best	0.992	0.986	0.986	0.978	0.975	0.963

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.992	0.764	0.965	0.598
batch 2	0.719	0.499	0.774	0.556

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	Paired-related HD {3.1.3} (TFClass)
TF subfamily	ESX {3.1.3.8} (TFClass)
TFClass ID	TFClass: 3.1.3.8.1
HGNC	HGNC:14865
MGI
EntrezGene (human)	GeneID:80712 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	ESX1_HUMAN
UniProt ID (mouse)
UniProt AC (human)	Q8N693 (TFClass)
UniProt AC (mouse)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	ESX1.H12RSNP.0.SM.B.pcm
PWM	ESX1.H12RSNP.0.SM.B.pwm
PFM	ESX1.H12RSNP.0.SM.B.pfm
Alignment	ESX1.H12RSNP.0.SM.B.words.tsv
Threshold to P-value map	ESX1.H12RSNP.0.SM.B.thr
Motif in other formats
JASPAR format	ESX1.H12RSNP.0.SM.B_jaspar_format.txt
MEME format	ESX1.H12RSNP.0.SM.B_meme_format.meme
Transfac format	ESX1.H12RSNP.0.SM.B_transfac_format.txt
Homer format	ESX1.H12RSNP.0.SM.B_homer_format_0.001.txt ESX1.H12RSNP.0.SM.B_homer_format_0.0005.txt ESX1.H12RSNP.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2595.5	2602.5	2797.5	1736.5
02	1673.25	2493.25	3328.25	2237.25
03	259.0	3193.0	323.0	5957.0
04	6765.0	784.0	2081.0	102.0
05	9657.0	54.0	21.0	0.0
06	0.0	0.0	0.0	9732.0
07	0.0	2.0	0.0	9730.0
08	9716.0	0.0	16.0	0.0
09	2389.0	1679.0	5058.0	606.0
10	447.5	3920.5	2527.5	2836.5
11	2033.75	2319.75	3197.75	2180.75

PFM

	A	C	G	T
01	0.267	0.267	0.287	0.178
02	0.172	0.256	0.342	0.23
03	0.027	0.328	0.033	0.612
04	0.695	0.081	0.214	0.01
05	0.992	0.006	0.002	0.0
06	0.0	0.0	0.0	1.0
07	0.0	0.0	0.0	1.0
08	0.998	0.0	0.002	0.0
09	0.245	0.173	0.52	0.062
10	0.046	0.403	0.26	0.291
11	0.209	0.238	0.329	0.224

PWM

	A	C	G	T
01	0.065	0.067	0.139	-0.337
02	-0.374	0.024	0.313	-0.084
03	-2.232	0.272	-2.013	0.895
04	1.022	-1.13	-0.156	-3.151
05	1.378	-3.767	-4.65	-6.967
06	-6.967	-6.967	-6.967	1.386
07	-6.967	-6.34	-6.967	1.385
08	1.384	-6.967	-4.891	-6.967
09	-0.018	-0.371	0.731	-1.387
10	-1.689	0.477	0.038	0.153
11	-0.179	-0.048	0.273	-0.109

Standard thresholds

P-value	Threshold
0.001	5.019645
0.0005	6.119425
0.0001	7.678165