ESX1.H12INVITRO.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ESX1.H12INVITRO.1.S.B
Gene (human)	ESX1 (GeneCards)
Gene synonyms (human)	ESX1L, ESX1R
Gene (mouse)
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	18
Consensus	hWWWdnRSTAATTAGbbn
GC content	33.77%
Information content (bits; total / per base)	16.512 / 0.917
Data sources	HT-SELEX
Aligned words	721

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.971	0.951	0.95	0.924	0.925	0.89
Overall, 10 experiments	best	0.995	0.992	0.991	0.986	0.978	0.969
Methyl HT-SELEX, 3 experiments	median	0.966	0.942	0.953	0.924	0.927	0.894
Methyl HT-SELEX, 3 experiments	best	0.98	0.966	0.972	0.953	0.955	0.932
Non-Methyl HT-SELEX, 7 experiments	median	0.975	0.96	0.948	0.924	0.923	0.886
Non-Methyl HT-SELEX, 7 experiments	best	0.995	0.992	0.991	0.986	0.978	0.969

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.969	0.447	0.944	0.637
batch 2	0.658	0.418	0.719	0.522

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	Paired-related HD {3.1.3} (TFClass)
TF subfamily	ESX {3.1.3.8} (TFClass)
TFClass ID	TFClass: 3.1.3.8.1
HGNC	HGNC:14865
MGI
EntrezGene (human)	GeneID:80712 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	ESX1_HUMAN
UniProt ID (mouse)
UniProt AC (human)	Q8N693 (TFClass)
UniProt AC (mouse)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	ESX1.H12INVITRO.1.S.B.pcm
PWM	ESX1.H12INVITRO.1.S.B.pwm
PFM	ESX1.H12INVITRO.1.S.B.pfm
Alignment	ESX1.H12INVITRO.1.S.B.words.tsv
Threshold to P-value map	ESX1.H12INVITRO.1.S.B.thr
Motif in other formats
JASPAR format	ESX1.H12INVITRO.1.S.B_jaspar_format.txt
MEME format	ESX1.H12INVITRO.1.S.B_meme_format.meme
Transfac format	ESX1.H12INVITRO.1.S.B_transfac_format.txt
Homer format	ESX1.H12INVITRO.1.S.B_homer_format_0.001.txt ESX1.H12INVITRO.1.S.B_homer_format_0.0005.txt ESX1.H12INVITRO.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	280.25	127.25	65.25	248.25
02	336.25	7.25	19.25	358.25
03	392.0	14.0	37.0	278.0
04	314.0	20.0	56.0	331.0
05	133.0	40.0	156.0	392.0
06	97.0	183.0	248.0	193.0
07	250.0	73.0	381.0	17.0
08	6.0	504.0	136.0	75.0
09	0.0	112.0	0.0	609.0
10	693.0	1.0	27.0	0.0
11	721.0	0.0	0.0	0.0
12	0.0	0.0	0.0	721.0
13	0.0	5.0	0.0	716.0
14	678.0	0.0	43.0	0.0
15	47.0	68.0	599.0	7.0
16	18.0	266.0	151.0	286.0
17	66.75	224.75	360.75	68.75
18	147.0	249.0	209.0	116.0

PFM

	A	C	G	T
01	0.389	0.176	0.09	0.344
02	0.466	0.01	0.027	0.497
03	0.544	0.019	0.051	0.386
04	0.436	0.028	0.078	0.459
05	0.184	0.055	0.216	0.544
06	0.135	0.254	0.344	0.268
07	0.347	0.101	0.528	0.024
08	0.008	0.699	0.189	0.104
09	0.0	0.155	0.0	0.845
10	0.961	0.001	0.037	0.0
11	1.0	0.0	0.0	0.0
12	0.0	0.0	0.0	1.0
13	0.0	0.007	0.0	0.993
14	0.94	0.0	0.06	0.0
15	0.065	0.094	0.831	0.01
16	0.025	0.369	0.209	0.397
17	0.093	0.312	0.5	0.095
18	0.204	0.345	0.29	0.161

PWM

	A	C	G	T
01	0.438	-0.344	-1.0	0.318
02	0.619	-3.018	-2.164	0.682
03	0.772	-2.453	-1.549	0.43
04	0.551	-2.129	-1.149	0.604
05	-0.301	-1.474	-0.143	0.772
06	-0.612	0.015	0.317	0.068
07	0.325	-0.891	0.744	-2.278
08	-3.169	1.022	-0.279	-0.864
09	-4.706	-0.47	-4.706	1.211
10	1.34	-4.231	-1.848	-4.706
11	1.379	-4.706	-4.706	-4.706
12	-4.706	-4.706	-4.706	1.379
13	-4.706	-3.31	-4.706	1.373
14	1.318	-4.706	-1.405	-4.706
15	-1.319	-0.96	1.195	-3.046
16	-2.226	0.386	-0.175	0.458
17	-0.978	0.219	0.689	-0.949
18	-0.202	0.321	0.147	-0.436

Standard thresholds

P-value	Threshold
0.001	1.64421
0.0005	3.06621
0.0001	6.01376