ESX1.H12INVITRO.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ESX1.H12INVITRO.0.SM.B
Gene (human)	ESX1 (GeneCards)
Gene synonyms (human)	ESX1L, ESX1R
Gene (mouse)
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	11
Consensus	nnYRATTAvbn
GC content	36.27%
Information content (bits; total / per base)	9.429 / 0.857
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9608

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.975	0.959	0.966	0.944	0.939	0.916
Overall, 10 experiments	best	0.993	0.989	0.989	0.982	0.976	0.966
Methyl HT-SELEX, 3 experiments	median	0.977	0.962	0.966	0.946	0.944	0.919
Methyl HT-SELEX, 3 experiments	best	0.988	0.981	0.984	0.973	0.973	0.959
Non-Methyl HT-SELEX, 7 experiments	median	0.974	0.955	0.965	0.942	0.937	0.915
Non-Methyl HT-SELEX, 7 experiments	best	0.993	0.989	0.989	0.982	0.976	0.966

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.993	0.771	0.964	0.604
batch 2	0.711	0.471	0.75	0.55

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	Paired-related HD {3.1.3} (TFClass)
TF subfamily	ESX {3.1.3.8} (TFClass)
TFClass ID	TFClass: 3.1.3.8.1
HGNC	HGNC:14865
MGI
EntrezGene (human)	GeneID:80712 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	ESX1_HUMAN
UniProt ID (mouse)
UniProt AC (human)	Q8N693 (TFClass)
UniProt AC (mouse)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	ESX1.H12INVITRO.0.SM.B.pcm
PWM	ESX1.H12INVITRO.0.SM.B.pwm
PFM	ESX1.H12INVITRO.0.SM.B.pfm
Alignment	ESX1.H12INVITRO.0.SM.B.words.tsv
Threshold to P-value map	ESX1.H12INVITRO.0.SM.B.thr
Motif in other formats
JASPAR format	ESX1.H12INVITRO.0.SM.B_jaspar_format.txt
MEME format	ESX1.H12INVITRO.0.SM.B_meme_format.meme
Transfac format	ESX1.H12INVITRO.0.SM.B_transfac_format.txt
Homer format	ESX1.H12INVITRO.0.SM.B_homer_format_0.001.txt ESX1.H12INVITRO.0.SM.B_homer_format_0.0005.txt ESX1.H12INVITRO.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2691.25	2620.25	2466.25	1830.25
02	1630.75	2868.75	3198.75	1909.75
03	419.0	3734.0	384.0	5071.0
04	5605.0	1465.0	2405.0	133.0
05	9306.0	219.0	83.0	0.0
06	0.0	0.0	0.0	9608.0
07	0.0	49.0	0.0	9559.0
08	9599.0	0.0	9.0	0.0
09	2451.0	2339.0	4097.0	721.0
10	430.75	4275.75	2805.75	2095.75
11	1964.0	2250.0	3067.0	2327.0

PFM

	A	C	G	T
01	0.28	0.273	0.257	0.19
02	0.17	0.299	0.333	0.199
03	0.044	0.389	0.04	0.528
04	0.583	0.152	0.25	0.014
05	0.969	0.023	0.009	0.0
06	0.0	0.0	0.0	1.0
07	0.0	0.005	0.0	0.995
08	0.999	0.0	0.001	0.0
09	0.255	0.243	0.426	0.075
10	0.045	0.445	0.292	0.218
11	0.204	0.234	0.319	0.242

PWM

	A	C	G	T
01	0.114	0.087	0.026	-0.272
02	-0.387	0.177	0.286	-0.229
03	-1.742	0.441	-1.828	0.747
04	0.847	-0.494	0.001	-2.878
05	1.354	-2.386	-3.339	-6.955
06	-6.955	-6.955	-6.955	1.386
07	-6.955	-3.847	-6.955	1.38
08	1.385	-6.955	-5.361	-6.955
09	0.02	-0.027	0.534	-1.201
10	-1.714	0.576	0.155	-0.136
11	-0.201	-0.065	0.244	-0.032

Standard thresholds

P-value	Threshold
0.001	5.330375
0.0005	6.315105
0.0001	7.492595