ESX1.H12CORE.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ESX1.H12CORE.1.S.B
Gene (human)	ESX1 (GeneCards)
Gene synonyms (human)	ESX1L, ESX1R
Gene (mouse)
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	17
Consensus	hWWhhnRYTAATTASbn
GC content	28.21%
Information content (bits; total / per base)	15.186 / 0.893
Data sources	HT-SELEX
Aligned words	692

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.967	0.943	0.951	0.922	0.929	0.893
Overall, 10 experiments	best	0.993	0.987	0.988	0.981	0.977	0.966
Methyl HT-SELEX, 3 experiments	median	0.962	0.932	0.952	0.92	0.93	0.895
Methyl HT-SELEX, 3 experiments	best	0.978	0.96	0.973	0.952	0.961	0.938
Non-Methyl HT-SELEX, 7 experiments	median	0.972	0.954	0.951	0.923	0.927	0.89
Non-Methyl HT-SELEX, 7 experiments	best	0.993	0.987	0.988	0.981	0.977	0.966

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.973	0.481	0.947	0.56
batch 2	0.675	0.471	0.726	0.531

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	Paired-related HD {3.1.3} (TFClass)
TF subfamily	ESX {3.1.3.8} (TFClass)
TFClass ID	TFClass: 3.1.3.8.1
HGNC	HGNC:14865
MGI
EntrezGene (human)	GeneID:80712 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	ESX1_HUMAN
UniProt ID (mouse)
UniProt AC (human)	Q8N693 (TFClass)
UniProt AC (mouse)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	ESX1.H12CORE.1.S.B.pcm
PWM	ESX1.H12CORE.1.S.B.pwm
PFM	ESX1.H12CORE.1.S.B.pfm
Alignment	ESX1.H12CORE.1.S.B.words.tsv
Threshold to P-value map	ESX1.H12CORE.1.S.B.thr
Motif in other formats
JASPAR format	ESX1.H12CORE.1.S.B_jaspar_format.txt
MEME format	ESX1.H12CORE.1.S.B_meme_format.meme
Transfac format	ESX1.H12CORE.1.S.B_transfac_format.txt
Homer format	ESX1.H12CORE.1.S.B_homer_format_0.001.txt ESX1.H12CORE.1.S.B_homer_format_0.0005.txt ESX1.H12CORE.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	240.25	124.25	71.25	256.25
02	299.5	46.5	21.5	324.5
03	392.0	36.0	57.0	207.0
04	285.0	67.0	41.0	299.0
05	119.0	91.0	75.0	407.0
06	209.0	152.0	157.0	174.0
07	360.0	53.0	266.0	13.0
08	2.0	395.0	68.0	227.0
09	0.0	117.0	0.0	575.0
10	691.0	0.0	1.0	0.0
11	692.0	0.0	0.0	0.0
12	0.0	0.0	0.0	692.0
13	0.0	2.0	0.0	690.0
14	659.0	0.0	33.0	0.0
15	88.0	108.0	484.0	12.0
16	87.75	289.75	174.75	139.75
17	190.0	132.0	256.0	114.0

PFM

	A	C	G	T
01	0.347	0.18	0.103	0.37
02	0.433	0.067	0.031	0.469
03	0.566	0.052	0.082	0.299
04	0.412	0.097	0.059	0.432
05	0.172	0.132	0.108	0.588
06	0.302	0.22	0.227	0.251
07	0.52	0.077	0.384	0.019
08	0.003	0.571	0.098	0.328
09	0.0	0.169	0.0	0.831
10	0.999	0.0	0.001	0.0
11	1.0	0.0	0.0	0.0
12	0.0	0.0	0.0	1.0
13	0.0	0.003	0.0	0.997
14	0.952	0.0	0.048	0.0
15	0.127	0.156	0.699	0.017
16	0.127	0.419	0.253	0.202
17	0.275	0.191	0.37	0.165

PWM

	A	C	G	T
01	0.326	-0.327	-0.874	0.39
02	0.545	-1.289	-2.021	0.625
03	0.813	-1.535	-1.091	0.178
04	0.496	-0.934	-1.41	0.543
05	-0.37	-0.634	-0.824	0.85
06	0.187	-0.128	-0.096	0.006
07	0.728	-1.162	0.427	-2.479
08	-3.872	0.82	-0.919	0.269
09	-4.671	-0.387	-4.671	1.195
10	1.378	-4.671	-4.194	-4.671
11	1.379	-4.671	-4.671	-4.671
12	-4.671	-4.671	-4.671	1.379
13	-4.671	-3.872	-4.671	1.376
14	1.331	-4.671	-1.618	-4.671
15	-0.667	-0.466	1.023	-2.55
16	-0.67	0.512	0.01	-0.211
17	0.093	-0.268	0.389	-0.412

Standard thresholds

P-value	Threshold
0.001	2.21006
0.0005	3.58016
0.0001	6.51796