ESR1.H12RSNP.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ESR1.H12RSNP.0.P.B
Gene (human)	ESR1 (GeneCards)
Gene synonyms (human)	ESR, NR3A1
Gene (mouse)	Esr1
Gene synonyms (mouse)	Esr, Estr, Estra, Nr3a1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	15
Consensus	RGGKCAbCbTGMCCY
GC content	59.99%
Information content (bits; total / per base)	15.07 / 1.005
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	269 (425)	0.876	0.979	0.838	0.98	0.858	0.978	4.194	7.328	279.678	670.745
Mouse	22 (29)	0.929	0.99	0.882	0.98	0.917	0.987	5.097	6.549	355.328	751.367

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.764	0.757	0.643	0.647	0.578	0.589
Non-Methyl HT-SELEX, 1 experiments	best	0.764	0.757	0.643	0.647	0.578	0.589

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.279	17.256	0.122	0.088

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Steroid hormone receptors {2.1.1} (TFClass)
TF subfamily	ER-like (NR3A) {2.1.1.2} (TFClass)
TFClass ID	TFClass: 2.1.1.2.1
HGNC	HGNC:3467
MGI	MGI:1352467
EntrezGene (human)	GeneID:2099 (SSTAR profile)
EntrezGene (mouse)	GeneID:13982 (SSTAR profile)
UniProt ID (human)	ESR1_HUMAN
UniProt ID (mouse)	ESR1_MOUSE
UniProt AC (human)	P03372 (TFClass)
UniProt AC (mouse)	P19785 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	269 human, 22 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	ESR1.H12RSNP.0.P.B.pcm
PWM	ESR1.H12RSNP.0.P.B.pwm
PFM	ESR1.H12RSNP.0.P.B.pfm
Alignment	ESR1.H12RSNP.0.P.B.words.tsv
Threshold to P-value map	ESR1.H12RSNP.0.P.B.thr
Motif in other formats
JASPAR format	ESR1.H12RSNP.0.P.B_jaspar_format.txt
MEME format	ESR1.H12RSNP.0.P.B_meme_format.meme
Transfac format	ESR1.H12RSNP.0.P.B_transfac_format.txt
Homer format	ESR1.H12RSNP.0.P.B_homer_format_0.001.txt ESR1.H12RSNP.0.P.B_homer_format_0.0005.txt ESR1.H12RSNP.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	544.0	53.0	354.0	49.0
02	54.0	0.0	860.0	86.0
03	39.0	13.0	929.0	19.0
04	69.0	39.0	126.0	766.0
05	3.0	897.0	41.0	59.0
06	817.0	15.0	133.0	35.0
07	89.0	472.0	273.0	166.0
08	0.0	658.0	0.0	342.0
09	150.0	371.0	312.0	167.0
10	37.0	103.0	15.0	845.0
11	54.0	10.0	936.0	0.0
12	735.0	143.0	40.0	82.0
13	24.0	917.0	14.0	45.0
14	98.0	839.0	1.0	62.0
15	31.0	388.0	46.0	535.0

PFM

	A	C	G	T
01	0.544	0.053	0.354	0.049
02	0.054	0.0	0.86	0.086
03	0.039	0.013	0.929	0.019
04	0.069	0.039	0.126	0.766
05	0.003	0.897	0.041	0.059
06	0.817	0.015	0.133	0.035
07	0.089	0.472	0.273	0.166
08	0.0	0.658	0.0	0.342
09	0.15	0.371	0.312	0.167
10	0.037	0.103	0.015	0.845
11	0.054	0.01	0.936	0.0
12	0.735	0.143	0.04	0.082
13	0.024	0.917	0.014	0.045
14	0.098	0.839	0.001	0.062
15	0.031	0.388	0.046	0.535

PWM

	A	C	G	T
01	0.774	-1.526	0.346	-1.602
02	-1.508	-4.982	1.231	-1.054
03	-1.821	-2.839	1.308	-2.497
04	-1.27	-1.821	-0.678	1.115
05	-3.975	1.273	-1.774	-1.422
06	1.179	-2.711	-0.625	-1.925
07	-1.02	0.632	0.087	-0.406
08	-4.982	0.963	-4.982	0.312
09	-0.506	0.393	0.22	-0.4
10	-1.872	-0.877	-2.711	1.213
11	-1.508	-3.066	1.315	-4.982
12	1.074	-0.553	-1.797	-1.101
13	-2.281	1.295	-2.773	-1.684
14	-0.926	1.206	-4.525	-1.374
15	-2.04	0.437	-1.663	0.757

Standard thresholds

P-value	Threshold
0.001	3.11856
0.0005	4.23766
0.0001	6.58311