MotifESR1.H12INVITRO.1.P.B
Gene (human)ESR1
(GeneCards)
Gene synonyms (human)ESR, NR3A1
Gene (mouse)Esr1
Gene synonyms (mouse)Esr, Estr, Estra, Nr3a1
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length9
ConsensusnnTGACCYd
GC content51.59%
Information content (bits; total / per base)8.424 / 0.936
Data sourcesChIP-Seq
Aligned words516

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 269 (425) 0.837 0.925 0.737 0.873 0.787 0.879 2.232 2.758 160.222 418.051
Mouse 22 (29) 0.867 0.907 0.761 0.827 0.822 0.853 2.334 2.567 209.42 418.62

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Non-Methyl HT-SELEX, 1 experiments median 0.752 0.698 0.679 0.642 0.605 0.594
best 0.752 0.698 0.679 0.642 0.605 0.594

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 1.711 7.943 0.077 0.079
TF superclassZinc-coordinating DNA-binding domains {2} (TFClass)
TF classNuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF familySteroid hormone receptors {2.1.1} (TFClass)
TF subfamilyER-like (NR3A) {2.1.1.2} (TFClass)
TFClass IDTFClass: 2.1.1.2.1
HGNCHGNC:3467
MGIMGI:1352467
EntrezGene (human)GeneID:2099
(SSTAR profile)
EntrezGene (mouse)GeneID:13982
(SSTAR profile)
UniProt ID (human)ESR1_HUMAN
UniProt ID (mouse)ESR1_MOUSE
UniProt AC (human)P03372
(TFClass)
UniProt AC (mouse)P19785
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 269 human, 22 mouse
HT-SELEX 1
Methyl-HT-SELEX 0
PCM
ACGT
01117.0139.0142.0118.0
02142.0142.0162.070.0
0312.03.03.0498.0
046.02.0498.010.0
05466.045.02.03.0
0614.0486.07.09.0
07122.0381.01.012.0
0841.0141.09.0325.0
09150.059.0174.0133.0
PFM
ACGT
010.2270.2690.2750.229
020.2750.2750.3140.136
030.0230.0060.0060.965
040.0120.0040.9650.019
050.9030.0870.0040.006
060.0270.9420.0140.017
070.2360.7380.0020.023
080.0790.2730.0170.63
090.2910.1140.3370.258
PWM
ACGT
01-0.0960.0740.095-0.088
020.0950.0950.225-0.601
03-2.265-3.354-3.3541.342
04-2.849-3.6021.342-2.424
051.276-1.031-3.602-3.354
06-2.1271.318-2.725-2.515
07-0.0551.075-3.931-2.265
08-1.1210.088-2.5150.917
090.149-0.7680.2960.03
Standard thresholds
P-value Threshold
0.001 5.30413
0.0005 6.173875
0.0001 7.434395