ESR1.H12INVITRO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ESR1.H12INVITRO.0.P.B
Gene (human)	ESR1 (GeneCards)
Gene synonyms (human)	ESR, NR3A1
Gene (mouse)	Esr1
Gene synonyms (mouse)	Esr, Estr, Estra, Nr3a1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	15
Consensus	RGGTCAvCnTGACCY
GC content	57.64%
Information content (bits; total / per base)	16.438 / 1.096
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	269 (425)	0.877	0.978	0.839	0.98	0.857	0.977	4.187	7.357	282.301	669.77
Mouse	22 (29)	0.924	0.99	0.879	0.979	0.915	0.987	5.114	6.613	363.569	758.854

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.774	0.765	0.656	0.655	0.591	0.597
Non-Methyl HT-SELEX, 1 experiments	best	0.774	0.765	0.656	0.655	0.591	0.597

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.087	14.036	0.114	0.085

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Steroid hormone receptors {2.1.1} (TFClass)
TF subfamily	ER-like (NR3A) {2.1.1.2} (TFClass)
TFClass ID	TFClass: 2.1.1.2.1
HGNC	HGNC:3467
MGI	MGI:1352467
EntrezGene (human)	GeneID:2099 (SSTAR profile)
EntrezGene (mouse)	GeneID:13982 (SSTAR profile)
UniProt ID (human)	ESR1_HUMAN
UniProt ID (mouse)	ESR1_MOUSE
UniProt AC (human)	P03372 (TFClass)
UniProt AC (mouse)	P19785 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	269 human, 22 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	ESR1.H12INVITRO.0.P.B.pcm
PWM	ESR1.H12INVITRO.0.P.B.pwm
PFM	ESR1.H12INVITRO.0.P.B.pfm
Alignment	ESR1.H12INVITRO.0.P.B.words.tsv
Threshold to P-value map	ESR1.H12INVITRO.0.P.B.thr
Motif in other formats
JASPAR format	ESR1.H12INVITRO.0.P.B_jaspar_format.txt
MEME format	ESR1.H12INVITRO.0.P.B_meme_format.meme
Transfac format	ESR1.H12INVITRO.0.P.B_transfac_format.txt
Homer format	ESR1.H12INVITRO.0.P.B_homer_format_0.001.txt ESR1.H12INVITRO.0.P.B_homer_format_0.0005.txt ESR1.H12INVITRO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	621.0	34.0	302.0	43.0
02	61.0	2.0	828.0	109.0
03	27.0	4.0	960.0	9.0
04	42.0	27.0	111.0	820.0
05	1.0	919.0	24.0	56.0
06	904.0	7.0	72.0	17.0
07	133.0	423.0	313.0	131.0
08	353.0	647.0	0.0	0.0
09	192.0	329.0	278.0	201.0
10	29.0	87.0	3.0	881.0
11	46.0	4.0	948.0	2.0
12	806.0	124.0	25.0	45.0
13	19.0	943.0	3.0	35.0
14	106.0	839.0	0.0	55.0
15	37.0	351.0	39.0	573.0

PFM

	A	C	G	T
01	0.621	0.034	0.302	0.043
02	0.061	0.002	0.828	0.109
03	0.027	0.004	0.96	0.009
04	0.042	0.027	0.111	0.82
05	0.001	0.919	0.024	0.056
06	0.904	0.007	0.072	0.017
07	0.133	0.423	0.313	0.131
08	0.353	0.647	0.0	0.0
09	0.192	0.329	0.278	0.201
10	0.029	0.087	0.003	0.881
11	0.046	0.004	0.948	0.002
12	0.806	0.124	0.025	0.045
13	0.019	0.943	0.003	0.035
14	0.106	0.839	0.0	0.055
15	0.037	0.351	0.039	0.573

PWM

	A	C	G	T
01	0.906	-1.952	0.188	-1.728
02	-1.39	-4.213	1.193	-0.821
03	-2.171	-3.783	1.34	-3.156
04	-1.75	-2.171	-0.803	1.183
05	-4.525	1.297	-2.281	-1.473
06	1.28	-3.362	-1.228	-2.598
07	-0.625	0.523	0.223	-0.64
08	0.343	0.947	-4.982	-4.982
09	-0.262	0.273	0.105	-0.216
10	-2.103	-1.043	-3.975	1.255
11	-1.663	-3.783	1.328	-4.213
12	1.166	-0.694	-2.243	-1.684
13	-2.497	1.323	-3.975	-1.925
14	-0.849	1.206	-4.982	-1.49
15	-1.872	0.337	-1.821	0.826

Standard thresholds

P-value	Threshold
0.001	2.32416
0.0005	3.57046
0.0001	6.17256