ESR1.H12CORE.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ESR1.H12CORE.1.P.B
Gene (human)	ESR1 (GeneCards)
Gene synonyms (human)	ESR, NR3A1
Gene (mouse)	Esr1
Gene synonyms (mouse)	Esr, Estr, Estra, Nr3a1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	9
Consensus	nnTGACCYd
GC content	51.59%
Information content (bits; total / per base)	8.424 / 0.936
Data sources	ChIP-Seq
Aligned words	516

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	269 (425)	0.837	0.925	0.737	0.873	0.787	0.879	2.232	2.758	160.222	418.051
Mouse	22 (29)	0.867	0.907	0.761	0.827	0.822	0.853	2.334	2.567	209.42	418.62

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.752	0.698	0.679	0.642	0.605	0.594
Non-Methyl HT-SELEX, 1 experiments	best	0.752	0.698	0.679	0.642	0.605	0.594

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	1.711	7.943	0.077	0.079

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Steroid hormone receptors {2.1.1} (TFClass)
TF subfamily	ER-like (NR3A) {2.1.1.2} (TFClass)
TFClass ID	TFClass: 2.1.1.2.1
HGNC	HGNC:3467
MGI	MGI:1352467
EntrezGene (human)	GeneID:2099 (SSTAR profile)
EntrezGene (mouse)	GeneID:13982 (SSTAR profile)
UniProt ID (human)	ESR1_HUMAN
UniProt ID (mouse)	ESR1_MOUSE
UniProt AC (human)	P03372 (TFClass)
UniProt AC (mouse)	P19785 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	269 human, 22 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	ESR1.H12CORE.1.P.B.pcm
PWM	ESR1.H12CORE.1.P.B.pwm
PFM	ESR1.H12CORE.1.P.B.pfm
Alignment	ESR1.H12CORE.1.P.B.words.tsv
Threshold to P-value map	ESR1.H12CORE.1.P.B.thr
Motif in other formats
JASPAR format	ESR1.H12CORE.1.P.B_jaspar_format.txt
MEME format	ESR1.H12CORE.1.P.B_meme_format.meme
Transfac format	ESR1.H12CORE.1.P.B_transfac_format.txt
Homer format	ESR1.H12CORE.1.P.B_homer_format_0.001.txt ESR1.H12CORE.1.P.B_homer_format_0.0005.txt ESR1.H12CORE.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	117.0	139.0	142.0	118.0
02	142.0	142.0	162.0	70.0
03	12.0	3.0	3.0	498.0
04	6.0	2.0	498.0	10.0
05	466.0	45.0	2.0	3.0
06	14.0	486.0	7.0	9.0
07	122.0	381.0	1.0	12.0
08	41.0	141.0	9.0	325.0
09	150.0	59.0	174.0	133.0

PFM

	A	C	G	T
01	0.227	0.269	0.275	0.229
02	0.275	0.275	0.314	0.136
03	0.023	0.006	0.006	0.965
04	0.012	0.004	0.965	0.019
05	0.903	0.087	0.004	0.006
06	0.027	0.942	0.014	0.017
07	0.236	0.738	0.002	0.023
08	0.079	0.273	0.017	0.63
09	0.291	0.114	0.337	0.258

PWM

	A	C	G	T
01	-0.096	0.074	0.095	-0.088
02	0.095	0.095	0.225	-0.601
03	-2.265	-3.354	-3.354	1.342
04	-2.849	-3.602	1.342	-2.424
05	1.276	-1.031	-3.602	-3.354
06	-2.127	1.318	-2.725	-2.515
07	-0.055	1.075	-3.931	-2.265
08	-1.121	0.088	-2.515	0.917
09	0.149	-0.768	0.296	0.03

Standard thresholds

P-value	Threshold
0.001	5.30413
0.0005	6.173875
0.0001	7.434395