ESR1.H12CORE.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ESR1.H12CORE.0.P.B
Gene (human)	ESR1 (GeneCards)
Gene synonyms (human)	ESR, NR3A1
Gene (mouse)	Esr1
Gene synonyms (mouse)	Esr, Estr, Estra, Nr3a1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	15
Consensus	RGGKCAbCnTGACCY
GC content	57.85%
Information content (bits; total / per base)	15.995 / 1.066
Data sources	ChIP-Seq
Aligned words	936

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	269 (425)	0.878	0.977	0.84	0.979	0.861	0.976	4.243	7.474	282.523	670.678
Mouse	22 (29)	0.927	0.99	0.882	0.98	0.915	0.987	5.129	6.588	357.194	743.854

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.773	0.764	0.655	0.654	0.59	0.597
Non-Methyl HT-SELEX, 1 experiments	best	0.773	0.764	0.655	0.654	0.59	0.597

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.237	16.476	0.116	0.085

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Steroid hormone receptors {2.1.1} (TFClass)
TF subfamily	ER-like (NR3A) {2.1.1.2} (TFClass)
TFClass ID	TFClass: 2.1.1.2.1
HGNC	HGNC:3467
MGI	MGI:1352467
EntrezGene (human)	GeneID:2099 (SSTAR profile)
EntrezGene (mouse)	GeneID:13982 (SSTAR profile)
UniProt ID (human)	ESR1_HUMAN
UniProt ID (mouse)	ESR1_MOUSE
UniProt AC (human)	P03372 (TFClass)
UniProt AC (mouse)	P19785 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	269 human, 22 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	ESR1.H12CORE.0.P.B.pcm
PWM	ESR1.H12CORE.0.P.B.pwm
PFM	ESR1.H12CORE.0.P.B.pfm
Alignment	ESR1.H12CORE.0.P.B.words.tsv
Threshold to P-value map	ESR1.H12CORE.0.P.B.thr
Motif in other formats
JASPAR format	ESR1.H12CORE.0.P.B_jaspar_format.txt
MEME format	ESR1.H12CORE.0.P.B_meme_format.meme
Transfac format	ESR1.H12CORE.0.P.B_transfac_format.txt
Homer format	ESR1.H12CORE.0.P.B_homer_format_0.001.txt ESR1.H12CORE.0.P.B_homer_format_0.0005.txt ESR1.H12CORE.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	592.0	52.0	254.0	38.0
02	46.0	5.0	787.0	98.0
03	32.0	6.0	882.0	16.0
04	43.0	23.0	147.0	723.0
05	1.0	853.0	23.0	59.0
06	800.0	8.0	92.0	36.0
07	72.0	455.0	259.0	150.0
08	0.0	554.0	0.0	382.0
09	150.0	305.0	318.0	163.0
10	15.0	80.0	7.0	834.0
11	62.0	13.0	860.0	1.0
12	739.0	127.0	17.0	53.0
13	8.0	891.0	8.0	29.0
14	105.0	787.0	1.0	43.0
15	40.0	267.0	41.0	588.0

PFM

	A	C	G	T
01	0.632	0.056	0.271	0.041
02	0.049	0.005	0.841	0.105
03	0.034	0.006	0.942	0.017
04	0.046	0.025	0.157	0.772
05	0.001	0.911	0.025	0.063
06	0.855	0.009	0.098	0.038
07	0.077	0.486	0.277	0.16
08	0.0	0.592	0.0	0.408
09	0.16	0.326	0.34	0.174
10	0.016	0.085	0.007	0.891
11	0.066	0.014	0.919	0.001
12	0.79	0.136	0.018	0.057
13	0.009	0.952	0.009	0.031
14	0.112	0.841	0.001	0.046
15	0.043	0.285	0.044	0.628

PWM

	A	C	G	T
01	0.924	-1.479	0.081	-1.781
02	-1.597	-3.559	1.208	-0.86
03	-1.945	-3.42	1.322	-2.588
04	-1.662	-2.255	-0.461	1.123
05	-4.466	1.288	-2.255	-1.356
06	1.224	-3.189	-0.922	-1.833
07	-1.162	0.661	0.101	-0.441
08	-4.926	0.858	-4.926	0.487
09	-0.441	0.263	0.305	-0.358
10	-2.647	-1.059	-3.298	1.266
11	-1.308	-2.774	1.296	-4.466
12	1.145	-0.605	-2.534	-1.461
13	-3.189	1.332	-3.189	-2.038
14	-0.792	1.208	-4.466	-1.662
15	-1.732	0.131	-1.708	0.917

Standard thresholds

P-value	Threshold
0.001	2.64601
0.0005	3.83531
0.0001	6.32411