ERR3.H12INVITRO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ERR3.H12INVITRO.0.PSM.A
Gene (human)	ESRRG (GeneCards)
Gene synonyms (human)	ERR3, ERRG2, KIAA0832, NR3B3
Gene (mouse)	Esrrg
Gene synonyms (mouse)	Err3, Kiaa0832, Nr3b3
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	10
Consensus	hvAAGGTYRn
GC content	48.18%
Information content (bits; total / per base)	9.398 / 0.94
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	9824

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	3 (19)	0.881	0.921	0.787	0.842	0.892	0.914	3.65	4.013	133.319	282.678

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.994	0.99	0.985	0.979	0.938	0.928
Overall, 6 experiments	best	0.998	0.996	0.996	0.993	0.987	0.982
Methyl HT-SELEX, 2 experiments	median	0.996	0.994	0.992	0.988	0.966	0.96
Methyl HT-SELEX, 2 experiments	best	0.997	0.996	0.995	0.993	0.987	0.982
Non-Methyl HT-SELEX, 4 experiments	median	0.863	0.866	0.794	0.801	0.742	0.746
Non-Methyl HT-SELEX, 4 experiments	best	0.998	0.996	0.996	0.993	0.986	0.981

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Steroid hormone receptors {2.1.1} (TFClass)
TF subfamily	ER-like (NR3A) {2.1.1.2} (TFClass)
TFClass ID	TFClass: 2.1.1.2.5
HGNC	HGNC:3474
MGI	MGI:1347056
EntrezGene (human)	GeneID:2104 (SSTAR profile)
EntrezGene (mouse)	GeneID:26381 (SSTAR profile)
UniProt ID (human)	ERR3_HUMAN
UniProt ID (mouse)	ERR3_MOUSE
UniProt AC (human)	P62508 (TFClass)
UniProt AC (mouse)	P62509 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 3 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	ERR3.H12INVITRO.0.PSM.A.pcm
PWM	ERR3.H12INVITRO.0.PSM.A.pwm
PFM	ERR3.H12INVITRO.0.PSM.A.pfm
Alignment	ERR3.H12INVITRO.0.PSM.A.words.tsv
Threshold to P-value map	ERR3.H12INVITRO.0.PSM.A.thr
Motif in other formats
JASPAR format	ERR3.H12INVITRO.0.PSM.A_jaspar_format.txt
MEME format	ERR3.H12INVITRO.0.PSM.A_meme_format.meme
Transfac format	ERR3.H12INVITRO.0.PSM.A_transfac_format.txt
Homer format	ERR3.H12INVITRO.0.PSM.A_homer_format_0.001.txt ERR3.H12INVITRO.0.PSM.A_homer_format_0.0005.txt ERR3.H12INVITRO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1903.25	2140.25	1779.25	4001.25
02	1437.5	5113.5	2358.5	914.5
03	8220.0	223.0	997.0	384.0
04	9421.0	99.0	187.0	117.0
05	19.0	32.0	9590.0	183.0
06	23.0	21.0	9744.0	36.0
07	685.0	224.0	750.0	8165.0
08	649.0	6892.0	1121.0	1162.0
09	6570.0	543.0	1917.0	794.0
10	2756.0	1990.0	1608.0	3470.0

PFM

	A	C	G	T
01	0.194	0.218	0.181	0.407
02	0.146	0.521	0.24	0.093
03	0.837	0.023	0.101	0.039
04	0.959	0.01	0.019	0.012
05	0.002	0.003	0.976	0.019
06	0.002	0.002	0.992	0.004
07	0.07	0.023	0.076	0.831
08	0.066	0.702	0.114	0.118
09	0.669	0.055	0.195	0.081
10	0.281	0.203	0.164	0.353

PWM

	A	C	G	T
01	-0.255	-0.137	-0.322	0.488
02	-0.535	0.733	-0.04	-0.986
03	1.207	-2.39	-0.9	-1.851
04	1.344	-3.189	-2.564	-3.026
05	-4.749	-4.272	1.361	-2.585
06	-4.576	-4.659	1.377	-4.162
07	-1.274	-2.385	-1.184	1.201
08	-1.328	1.031	-0.783	-0.747
09	0.983	-1.506	-0.248	-1.127
10	0.115	-0.21	-0.423	0.345

Standard thresholds

P-value	Threshold
0.001	4.92906
0.0005	5.733135
0.0001	7.36073