ERR2.H12RSNP.0.PSM.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ERR2.H12RSNP.0.PSM.D
Gene (human)	ESRRB (GeneCards)
Gene synonyms (human)	ERRB2, ESRL2, NR3B2
Gene (mouse)	Esrrb
Gene synonyms (mouse)	Err-2, Err2, Nr3b2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	D

Motif length	12
Consensus	nbSAAGGTCAhn
GC content	48.32%
Information content (bits; total / per base)	13.7 / 1.142
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	9986

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	34 (198)	0.909	0.969	0.814	0.921	0.892	0.976	3.479	5.429	166.619	512.585

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.964	0.955	0.795	0.803	0.657	0.685
Overall, 3 experiments	best	0.977	0.971	0.832	0.836	0.678	0.707
Methyl HT-SELEX, 1 experiments	median	0.964	0.955	0.795	0.803	0.657	0.685
Methyl HT-SELEX, 1 experiments	best	0.964	0.955	0.795	0.803	0.657	0.685
Non-Methyl HT-SELEX, 2 experiments	median	0.807	0.805	0.703	0.706	0.609	0.627
Non-Methyl HT-SELEX, 2 experiments	best	0.977	0.971	0.832	0.836	0.678	0.707

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Steroid hormone receptors {2.1.1} (TFClass)
TF subfamily	ER-like (NR3A) {2.1.1.2} (TFClass)
TFClass ID	TFClass: 2.1.1.2.4
HGNC	HGNC:3473
MGI	MGI:1346832
EntrezGene (human)	GeneID:2103 (SSTAR profile)
EntrezGene (mouse)	GeneID:26380 (SSTAR profile)
UniProt ID (human)	ERR2_HUMAN
UniProt ID (mouse)	ERR2_MOUSE
UniProt AC (human)	O95718 (TFClass)
UniProt AC (mouse)	Q61539 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 34 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	ERR2.H12RSNP.0.PSM.D.pcm
PWM	ERR2.H12RSNP.0.PSM.D.pwm
PFM	ERR2.H12RSNP.0.PSM.D.pfm
Alignment	ERR2.H12RSNP.0.PSM.D.words.tsv
Threshold to P-value map	ERR2.H12RSNP.0.PSM.D.thr
Motif in other formats
JASPAR format	ERR2.H12RSNP.0.PSM.D_jaspar_format.txt
MEME format	ERR2.H12RSNP.0.PSM.D_meme_format.meme
Transfac format	ERR2.H12RSNP.0.PSM.D_transfac_format.txt
Homer format	ERR2.H12RSNP.0.PSM.D_homer_format_0.001.txt ERR2.H12RSNP.0.PSM.D_homer_format_0.0005.txt ERR2.H12RSNP.0.PSM.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1963.5	2185.5	2878.5	2958.5
02	1081.75	1923.75	1248.75	5731.75
03	567.0	6968.0	2163.0	288.0
04	9629.0	5.0	311.0	41.0
05	9976.0	3.0	6.0	1.0
06	0.0	0.0	9980.0	6.0
07	0.0	0.0	9986.0	0.0
08	141.0	4.0	229.0	9612.0
09	15.0	9492.0	99.0	380.0
10	7637.0	21.0	2318.0	10.0
11	2432.0	2445.0	738.0	4371.0
12	2445.5	2052.5	2844.5	2643.5

PFM

	A	C	G	T
01	0.197	0.219	0.288	0.296
02	0.108	0.193	0.125	0.574
03	0.057	0.698	0.217	0.029
04	0.964	0.001	0.031	0.004
05	0.999	0.0	0.001	0.0
06	0.0	0.0	0.999	0.001
07	0.0	0.0	1.0	0.0
08	0.014	0.0	0.023	0.963
09	0.002	0.951	0.01	0.038
10	0.765	0.002	0.232	0.001
11	0.244	0.245	0.074	0.438
12	0.245	0.206	0.285	0.265

PWM

	A	C	G	T
01	-0.24	-0.133	0.142	0.17
02	-0.835	-0.26	-0.692	0.831
03	-1.479	1.026	-0.143	-2.153
04	1.349	-5.835	-2.076	-4.055
05	1.385	-6.155	-5.707	-6.629
06	-6.99	-6.99	1.385	-5.707
07	-6.99	-6.99	1.386	-6.99
08	-2.859	-5.983	-2.38	1.347
09	-4.973	1.335	-3.205	-1.877
10	1.117	-4.675	-0.074	-5.314
11	-0.026	-0.021	-1.217	0.56
12	-0.021	-0.196	0.13	0.057

Standard thresholds

P-value	Threshold
0.001	2.21847
0.0005	3.75537
0.0001	6.904525