ERR2.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ERR2.H12INVIVO.0.PSM.A
Gene (human)	ESRRB (GeneCards)
Gene synonyms (human)	ERRB2, ESRL2, NR3B2
Gene (mouse)	Esrrb
Gene synonyms (mouse)	Err-2, Err2, Nr3b2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	16
Consensus	nnbSAAGGTCAnnnnv
GC content	51.65%
Information content (bits; total / per base)	12.538 / 0.784
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	998

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	34 (198)	0.91	0.967	0.823	0.925	0.902	0.973	3.813	5.65	164.801	505.377

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.943	0.929	0.785	0.785	0.657	0.677
Overall, 3 experiments	best	0.964	0.954	0.818	0.818	0.668	0.696
Methyl HT-SELEX, 1 experiments	median	0.943	0.929	0.785	0.785	0.657	0.677
Methyl HT-SELEX, 1 experiments	best	0.943	0.929	0.785	0.785	0.657	0.677
Non-Methyl HT-SELEX, 2 experiments	median	0.777	0.773	0.682	0.684	0.597	0.613
Non-Methyl HT-SELEX, 2 experiments	best	0.964	0.954	0.818	0.818	0.668	0.696

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Steroid hormone receptors {2.1.1} (TFClass)
TF subfamily	ER-like (NR3A) {2.1.1.2} (TFClass)
TFClass ID	TFClass: 2.1.1.2.4
HGNC	HGNC:3473
MGI	MGI:1346832
EntrezGene (human)	GeneID:2103 (SSTAR profile)
EntrezGene (mouse)	GeneID:26380 (SSTAR profile)
UniProt ID (human)	ERR2_HUMAN
UniProt ID (mouse)	ERR2_MOUSE
UniProt AC (human)	O95718 (TFClass)
UniProt AC (mouse)	Q61539 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 34 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	ERR2.H12INVIVO.0.PSM.A.pcm
PWM	ERR2.H12INVIVO.0.PSM.A.pwm
PFM	ERR2.H12INVIVO.0.PSM.A.pfm
Alignment	ERR2.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	ERR2.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	ERR2.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	ERR2.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	ERR2.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	ERR2.H12INVIVO.0.PSM.A_homer_format_0.001.txt ERR2.H12INVIVO.0.PSM.A_homer_format_0.0005.txt ERR2.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	171.0	211.0	379.0	237.0
02	144.0	242.0	315.0	297.0
03	76.0	235.0	205.0	482.0
04	109.0	653.0	209.0	27.0
05	921.0	7.0	53.0	17.0
06	972.0	0.0	23.0	3.0
07	13.0	0.0	971.0	14.0
08	1.0	9.0	985.0	3.0
09	67.0	7.0	83.0	841.0
10	5.0	883.0	76.0	34.0
11	961.0	7.0	23.0	7.0
12	295.0	313.0	198.0	192.0
13	308.0	292.0	235.0	163.0
14	158.0	275.0	296.0	269.0
15	255.0	187.0	202.0	354.0
16	188.0	371.0	302.0	137.0

PFM

	A	C	G	T
01	0.171	0.211	0.38	0.237
02	0.144	0.242	0.316	0.298
03	0.076	0.235	0.205	0.483
04	0.109	0.654	0.209	0.027
05	0.923	0.007	0.053	0.017
06	0.974	0.0	0.023	0.003
07	0.013	0.0	0.973	0.014
08	0.001	0.009	0.987	0.003
09	0.067	0.007	0.083	0.843
10	0.005	0.885	0.076	0.034
11	0.963	0.007	0.023	0.007
12	0.296	0.314	0.198	0.192
13	0.309	0.293	0.235	0.163
14	0.158	0.276	0.297	0.27
15	0.256	0.187	0.202	0.355
16	0.188	0.372	0.303	0.137

PWM

	A	C	G	T
01	-0.375	-0.166	0.416	-0.051
02	-0.545	-0.03	0.232	0.173
03	-1.173	-0.059	-0.195	0.655
04	-0.819	0.958	-0.176	-2.169
05	1.301	-3.36	-1.524	-2.596
06	1.355	-4.98	-2.318	-3.973
07	-2.837	-4.98	1.354	-2.771
08	-4.523	-3.154	1.368	-3.973
09	-1.296	-3.36	-1.087	1.21
10	-3.62	1.259	-1.173	-1.95
11	1.343	-3.36	-2.318	-3.36
12	0.166	0.225	-0.229	-0.26
13	0.209	0.156	-0.059	-0.422
14	-0.453	0.097	0.17	0.075
15	0.022	-0.286	-0.21	0.348
16	-0.281	0.394	0.19	-0.594

Standard thresholds

P-value	Threshold
0.001	3.84831
0.0005	4.94256
0.0001	7.15046