ERR1.H12RSNP.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ERR1.H12RSNP.0.PSM.A
Gene (human)	ESRRA (GeneCards)
Gene synonyms (human)	ERR1, ESRL1, NR3B1
Gene (mouse)	Esrra
Gene synonyms (mouse)	Err1, Estrra, Nr3b1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	14
Consensus	bbMAAGGTCAbnnn
GC content	53.51%
Information content (bits; total / per base)	12.335 / 0.881
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	15 (99)	0.898	0.964	0.821	0.937	0.897	0.95	4.18	5.024	213.886	332.284
Mouse	5 (32)	0.904	0.973	0.8	0.932	0.897	0.975	3.794	5.034	195.845	328.699

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.967	0.958	0.807	0.815	0.663	0.693
Overall, 8 experiments	best	0.998	0.997	0.997	0.995	0.993	0.99
Methyl HT-SELEX, 2 experiments	median	0.994	0.99	0.98	0.973	0.917	0.917
Methyl HT-SELEX, 2 experiments	best	0.998	0.997	0.997	0.995	0.993	0.99
Non-Methyl HT-SELEX, 6 experiments	median	0.941	0.934	0.74	0.759	0.616	0.652
Non-Methyl HT-SELEX, 6 experiments	best	0.997	0.994	0.994	0.991	0.986	0.98

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	12.233	4.809	0.226	0.099

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Steroid hormone receptors {2.1.1} (TFClass)
TF subfamily	ER-like (NR3A) {2.1.1.2} (TFClass)
TFClass ID	TFClass: 2.1.1.2.3
HGNC	HGNC:3471
MGI	MGI:1346831
EntrezGene (human)	GeneID:2101 (SSTAR profile)
EntrezGene (mouse)	GeneID:26379 (SSTAR profile)
UniProt ID (human)	ERR1_HUMAN
UniProt ID (mouse)	ERR1_MOUSE
UniProt AC (human)	P11474 (TFClass)
UniProt AC (mouse)	O08580 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	15 human, 5 mouse
HT-SELEX	6
Methyl-HT-SELEX	2

PCM	ERR1.H12RSNP.0.PSM.A.pcm
PWM	ERR1.H12RSNP.0.PSM.A.pwm
PFM	ERR1.H12RSNP.0.PSM.A.pfm
Alignment	ERR1.H12RSNP.0.PSM.A.words.tsv
Threshold to P-value map	ERR1.H12RSNP.0.PSM.A.thr
Motif in other formats
JASPAR format	ERR1.H12RSNP.0.PSM.A_jaspar_format.txt
MEME format	ERR1.H12RSNP.0.PSM.A_meme_format.meme
Transfac format	ERR1.H12RSNP.0.PSM.A_transfac_format.txt
Homer format	ERR1.H12RSNP.0.PSM.A_homer_format_0.001.txt ERR1.H12RSNP.0.PSM.A_homer_format_0.0005.txt ERR1.H12RSNP.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	93.0	442.0	268.0	197.0
02	71.0	430.0	91.0	408.0
03	167.0	658.0	146.0	29.0
04	836.0	9.0	149.0	6.0
05	947.0	4.0	41.0	8.0
06	20.0	2.0	965.0	13.0
07	7.0	7.0	973.0	13.0
08	60.0	10.0	42.0	888.0
09	8.0	914.0	55.0	23.0
10	931.0	8.0	47.0	14.0
11	141.0	531.0	151.0	177.0
12	332.0	234.0	217.0	217.0
13	166.0	330.0	294.0	210.0
14	295.0	194.0	280.0	231.0

PFM

	A	C	G	T
01	0.093	0.442	0.268	0.197
02	0.071	0.43	0.091	0.408
03	0.167	0.658	0.146	0.029
04	0.836	0.009	0.149	0.006
05	0.947	0.004	0.041	0.008
06	0.02	0.002	0.965	0.013
07	0.007	0.007	0.973	0.013
08	0.06	0.01	0.042	0.888
09	0.008	0.914	0.055	0.023
10	0.931	0.008	0.047	0.014
11	0.141	0.531	0.151	0.177
12	0.332	0.234	0.217	0.217
13	0.166	0.33	0.294	0.21
14	0.295	0.194	0.28	0.231

PWM

	A	C	G	T
01	-0.977	0.567	0.069	-0.236
02	-1.242	0.539	-0.999	0.487
03	-0.4	0.963	-0.533	-2.103
04	1.202	-3.156	-0.513	-3.484
05	1.327	-3.783	-1.774	-3.253
06	-2.45	-4.213	1.346	-2.839
07	-3.362	-3.362	1.354	-2.839
08	-1.406	-3.066	-1.75	1.263
09	-3.253	1.291	-1.49	-2.32
10	1.31	-3.253	-1.642	-2.773
11	-0.567	0.75	-0.5	-0.342
12	0.282	-0.066	-0.141	-0.141
13	-0.406	0.276	0.161	-0.173
14	0.164	-0.252	0.113	-0.078

Standard thresholds

P-value	Threshold
0.001	4.00791
0.0005	5.03196
0.0001	7.13716